NB100-56113

Peng W, de Bruijn HS, Ten Hagen TLM, van Dam GM, Roodenburg JLN, Berg K, Witjes MJH, Robinson DJ
Photochemistry and photobiology 2020 May;96(3):708-717

Eicosapentaenoic and docosapentaenoic acids lessen the expression of PPARγ/Cidec affecting adipogenesis in cultured 3T3-L1 adipocytes.

Martins FF, Aguila MB, Mandarim-de-Lacerda CA
Acta histochemica 2020 Feb;122(2):151504

Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection.

Stojanovic B, Milovanovic J, Arsenijevic A, Stojanovic B, Strazic Geljic I, Arsenijevic N, Jonjic S, Lukic ML, Milovanovic M
Frontiers in microbiology 2019;10:185

Neuronal life or death linked to depression treatment: the interplay between drugs and their stress-related outcomes relate to single or combined drug therapies.

Solek P, Koszla O, Mytych J, Badura J, Chelminiak Z, Cuprys M, Fraczek J, Tabecka-Lonczynska A, Koziorowski M
Apoptosis : an international journal on programmed cell death 2019 Oct;24(9-10):773-784

Caveolin-1 enhances metastasis formation in a human model of embryonal rhabdomyosarcoma through Erk signaling cooperation.

Codenotti S, Faggi F, Ronca R, Chiodelli P, Grillo E, Guescini M, Megiorni F, Marampon F, Fanzani A
Cancer letters 2019 May 1;449:135-144

Autophagy and Oncosis/Necroptosis Are Enhanced in Cardiomyocytes from Heart Failure Patients.

Corsetti G, Chen-Scarabelli C, Romano C, Pasini E, Dioguardi FS, Onorati F, Knight R, Patel H, Saravolatz L, Faggian G, Scarabelli TM
Medical science monitor basic research 2019 Feb 4;25:33-44

Salivary glands require Aurora Kinase B for regeneration after transient innate immune-mediated injury.

Shaalan A, Proctor G
Scientific reports 2019 Aug 5;9(1):11339

Down-regulation of miR-200c attenuates AngII-induced cardiac hypertrophy via targeting the MLCK-mediated pathway.

Hu S, Cheng M, Guo X, Wang S, Liu B, Jiang H, Huang C, Wu G
Journal of cellular and molecular medicine 2019 Apr;23(4):2505-2516

A natural molecule, urolithin A, downregulates androgen receptor activation and suppresses growth of prostate cancer.

Dahiya NR, Chandrasekaran B, Kolluru V, Ankem M, Damodaran C, Vadhanam MV
Molecular carcinogenesis 2018 Oct;57(10):1332-1341

G-quartet oligonucleotide mediated delivery of functional X-linked inhibitor of apoptosis protein into retinal cells following intravitreal injection.

Talreja D, Cashman SM, Dasari B, Kumar B, Kumar-Singh R
Experimental eye research 2018 Oct;175:20-31

Aloe arborescens juice prevents EMF-induced oxidative stress and thus protects from pathophysiology in the male reproductive system in vitro.

Solek P, Majchrowicz L, Koziorowski M
Environmental research 2018 Oct;166:141-149

Metformin Protects Against Spinal Cord Injury by Regulating Autophagy via the mTOR Signaling Pathway.

Guo Y, Wang F, Li H, Liang H, Li Y, Gao Z, He X
Neurochemical research 2018 May;43(5):1111-1117

Deficiency of Dab2 (Disabled Homolog 2) in Myeloid Cells Exacerbates Inflammation in Liver and Atherosclerotic Plaques in LDLR (Low-Density Lipoprotein Receptor)-Null Mice-Brief Report.

Adamson SE, Polanowska-Grabowska R, Marqueen K, Griffiths R, Angdisen J, Breevoort SR, Schulman IG, Leitinger N
Arteriosclerosis, thrombosis, and vascular biology 2018 May;38(5):1020-1029

The organic ester O,O'-diethyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate dihydrochloride attenuates murine breast cancer growth and metastasis.

Jurisevic M, Arsenijevic A, Pantic J, Gajovic N, Milovanovic J, Milovanovic M, Poljarevic J, Sabo T, Vojvodic D, Radosavljevic GD, Arsenijevic N
Oncotarget 2018 Jun 15;9(46):28195-28212

IL-33 receptor (ST2) deficiency downregulates myeloid precursors, inflammatory NK and dendritic cells in early phase of sepsis.

Babic ZM, Zunic FZ, Pantic JM, Radosavljevic GD, Jovanovic IP, Arsenijevic NN, Lukic ML
Journal of biomedical science 2018 Jul 12;25(1):56

Caspases are key regulators of inflammatory and innate immune responses mediated by TLR3 in vivo.

Shaalan A, Carpenter G, Proctor G
Molecular immunology 2018 Feb;94:190-199

Pulsed or continuous electromagnetic field induce p53/p21-mediated apoptotic signaling pathway in mouse spermatogenic cells in vitro and thus may affect male fertility.

Solek P, Majchrowicz L, Bloniarz D, Krotoszynska E, Koziorowski M
Toxicology 2017 May 1;382:84-92

Pain Input Impairs Recovery after Spinal Cord Injury: Treatment with Lidocaine.

Turtle JD, Strain MM, Aceves M, Huang YJ, Reynolds JA, Hook MA, Grau JW
Journal of neurotrauma 2017 Mar 15;34(6):1200-1208

Angiopoietin-like 4 Mediates Colonic Inflammation by Regulating Chemokine Transcript Stability via Tristetraprolin.

Phua T, Sng MK, Tan EH, Chee DS, Li Y, Wee JW, Teo Z, Chan JS, Lim MM, Tan CK, Zhu P, Arulampalam V, Tan NS
Scientific reports 2017 Mar 13;7:44351

Endoplasmic Reticulum Stress and Apoptosis Triggered by Sub-Chronic Lead Exposure in Mice Spleen: a Histopathological Study.

Corsetti G, Romano C, Stacchiotti A, Pasini E, Dioguardi FS
Biological trace element research 2017 Jul;178(1):86-97

Nephro-toxic effects of intraperitoneally injected EGCG in diabetic mice: involvement of oxidative stress, inflammation and apoptosis.

Rasheed NO, Ahmed LA, Abdallah DM, El-Sayeh BM
Scientific reports 2017 Jan 18;7:40617

Protective role of klotho protein on epithelial cells upon co-culture with activated or senescent monocytes.

Mytych J, Wos I, Solek P, Koziorowski M
Experimental cell research 2017 Jan 15;350(2):358-367

Induction of Bex genes by curcumin is associated with apoptosis and activation of p53 in N2a neuroblastoma cells.

Sidhar H, Giri RK
Scientific reports 2017 Feb 1;7:41420

Long-term culture with lipopolysaccharide induces dose-dependent cytostatic and cytotoxic effects in THP-1 monocytes.

Mytych J, Romerowicz-Misielak M, Koziorowski M
Toxicology in vitro : an international journal published in association with BIBRA 2017 Aug;42:1-9

MiR-223-3p inhibits angiogenesis and promotes resistance to cetuximab in head and neck squamous cell carcinoma.

Bozec A, Zangari J, Butori-Pepino M, Ilie M, Lalvee S, Juhel T, Butori C, Brest P, Hofman P, Vouret-Craviari V
Oncotarget 2017 Aug 22;8(34):57174-57186

Tert-butylhydroquinone Ameliorates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Mice by Enhancing Nrf2-Independent Autophagy.

Li T, Sun KJ, Wang HD, Zhou ML, Ding K, Lu XY, Wei WT, Wang CX, Zhou XM
Neurochemical research 2015 Sep;40(9):1829-38

Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells.

Pradhan N, Pratheek BM, Garai A, Kumar A, Meena VS, Ghosh S, Singh S, Kumari S, Chandrashekar TK, Goswami C, Chattopadhyay S, Kar S, Maiti PK
Cell biology international 2014 Oct;38(10):1118-31

Peripheral noxious stimulation reduces withdrawal threshold to mechanical stimuli after spinal cord injury: role of tumor necrosis factor alpha and apoptosis.

Garraway SM, Woller SA, Huie JR, Hartman JJ, Hook MA, Miranda RC, Huang YJ, Ferguson AR, Grau JW
Pain 2014 Nov;155(11):2344-59

In vitro and in vivo anti-tumour effects of MPT0B014, a novel derivative aroylquinoline, and in combination with erlotinib in human non-small-cell lung cancer cells.

Tsai AC, Pai HC, Wang CY, Liou JP, Teng CM, Wang JC, Pan SL
British journal of pharmacology 2014 Jan;171(1):122-33

Angiostatin inhibits activation and migration of neutrophils.

Aulakh GK, Balachandran Y, Liu L, Singh B
Cell and tissue research 2014 Feb;355(2):375-96

Cycling exercise affects the expression of apoptosis-associated microRNAs after spinal cord injury in rats.

Liu G, Keeler BE, Zhukareva V, Houlé JD
Experimental neurology 2010 Nov;226(1):200-6

Up-regulation of histamine H4 receptors contributes to splenic apoptosis in septic mice: counteraction of the antiapoptotic action of nuclear factor-kappaB.

Matsuda N, Teramae H, Futatsugi M, Takano K, Yamamoto S, Tomita K, Suzuki T, Yokoo H, Koike K, Hattori Y
The Journal of pharmacology and experimental therapeutics 2010 Mar;332(3):730-7

Palatinose and oleic acid act together to prevent pancreatic islet disruption in nondiabetic obese Zucker rats.

Sato K, Arai H, Miyazawa Y, Fukaya M, Uebanso T, Koganei M, Sasaki H, Sato T, Yamamoto H, Taketani Y, Takeda E
The journal of medical investigation : JMI 2008 Aug;55(3-4):183-95

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Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Immunohistochemistry-Paraffin: Caspase-3 Antibody - (active/cleaved) [NB100-56113] - Dog ischemic brain stained for Active/Cleaved Caspase-3 expression using Caspase-3 Antibody - (active/cleaved)( NB100-56113) at 1:2000. Staining is seen in the nuclei of dying neurons (black arrow) but not in the morphologically normal nuclei (open arrows). Caspase-3 expression in the nucleus is considered to be a marker of active/caspase-3 expression and apoptosis. Hematoxylin-eosin counterstain.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Immunohistochemistry-Paraffin: Caspase-3 Antibody - (active/cleaved) [NB100-56113] - Irradiated mouse spleen stained for Active/Cleaved Caspase-3 expression using Caspase-3 Antibody - (active/cleaved) (NB100-56113) at 1:2000. Staining is seen in the nuclei of a subset of the cell population. Caspase-3 expression in the nucleus is considered to be a marker of active/caspase-3 expression and apoptosis. Hematoxylin-eosin counterstain.