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ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [139]
- Comments [0]
- Validations
- Immunocytochemistry [2]
- Immunohistochemistry [1]
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- Product number
- AF835 - Provider product page
- Provider
- R&D Systems
- Product name
- Human/Mouse Active Caspase-3 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Distinguishes apoptotic cells from non-apoptotic cells in immunohistochemistry. Detects the p17 subunit of Caspase-3, but does not detect the precursor form in Western blot. We recommend R&D Systems Affinity Purified Anti-Caspase-3 (Catalog # AF-605-NA) or Monoclonal Anti-Cleaved-Caspase-3 (Catalog # MAB835) for Western blot applications.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Antigen sequence
P42574- Isotype
- IgG
- Vial size
- 50 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references TBC1D24 regulates axonal outgrowth and membrane trafficking at the growth cone in rodent and human neurons.
SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating β-Catenin Nuclear Localization.
Loss of Ccbe1 affects cardiac-specification and cardiomyocyte differentiation in mouse embryonic stem cells.
Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells.
The protective effects of total paeony glycoside on ischemia/reperfusion injury in H9C2 cells via inhibition of the PI3K/Akt signaling pathway.
Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation.
PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification.
Tracking cellular and molecular changes in a species-specific manner during experimental tumor progression in vivo.
Intracellular attenuation of BMP signaling via CKIP-1/Smurf1 is essential during neural crest induction.
Epidermal-specific deletion of TC-PTP promotes UVB-induced epidermal cell survival through the regulation of Flk-1/JNK signaling.
Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres.
KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS.
A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway.
BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer.
An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages.
The kallikrein-Kinin system modulates the progression of colorectal liver metastases in a mouse model.
Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice.
Oxidative damage and impairment of protein quality control systems in keratinocytes exposed to a volatile organic compounds cocktail.
The Process of Engraftment of Myogenic Cells in Skeletal Muscles of Primates: Understanding Clinical Observations and Setting Directions in Cell Transplantation Research.
Caspase-3/-7-Specific Metabolic Precursor for Bioorthogonal Tracking of Tumor Apoptosis.
Low Dose Radiation Causes Skin Cancer in Mice and Has a Differential Effect on Distinct Epidermal Stem Cells.
Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium.
A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin.
The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries.
Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth.
VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis.
New tumor suppressor microRNAs target glypican-3 in human liver cancer.
Constitutive WNT/CTNNB1 activation triggers spermatogonial stem cell proliferation and germ cell depletion.
Bifidobacterium breve reduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD88-dependent manner.
Proliferation, differentiation and migration of SCA1-/CD31- cardiac side population cells in vitro and in vivo.
Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary.
Combined effects of atorvastatin and aspirin on growth and apoptosis in human prostate cancer cells.
Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression.
Glycogen synthase kinase-3 inhibition sensitizes human induced pluripotent stem cells to thiol-containing antioxidants induced apoptosis.
Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo.
Autophagy deficient keratinocytes display increased DNA damage, senescence and aberrant lipid composition after oxidative stress in vitro and in vivo.
Brinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density.
Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture.
Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue.
Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations.
Axonal Cleaved Caspase-3 Regulates Axon Targeting and Morphogenesis in the Developing Auditory Brainstem.
An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress.
Cord blood mononuclear cells prevent neuronal apoptosis in response to perinatal asphyxia in the newborn lamb.
Defining the cellular lineage hierarchy in the interfollicular epidermis of adult skin.
CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex.
cMyc Regulates the Size of the Premigratory Neural Crest Stem Cell Pool.
Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice.
Attenuation of Cerebral Ischemic Injury in Smad1 Deficient Mice.
Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response.
Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer.
Hepatocyte-specific deletion of ARNT (aryl hydrocarbon Receptor Nuclear Translocator) results in altered fibrotic gene expression in the thioacetamide model of liver injury.
Preclinical studies identify non-apoptotic low-level caspase-3 as therapeutic target in pemphigus vulgaris.
Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a ∆133p53α mimic.
Apoptosis-Related Factors in the Luteal Phase of the Domestic Cat and Their Involvement in the Persistence of Corpora Lutea in Lynx.
The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice.
TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.
Interactions of highly and low virulent Flavobacterium columnare isolates with gill tissue in carp and rainbow trout.
BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus.
Exacerbated experimental colitis in TNFAIP8-deficient mice.
Pulmonary alveolar macrophages contribute to the premetastatic niche by suppressing antitumor T cell responses in the lungs.
Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration.
Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours.
Epidermal growth factor attenuates tubular necrosis following mercuric chloride damage by regeneration of indigenous, not bone marrow-derived cells.
Differential sensitivity of prefrontal cortex and hippocampus to alcohol-induced toxicity.
Short term morphine exposure in vitro alters proliferation and differentiation of neural progenitor cells and promotes apoptosis via mu receptors.
Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity.
Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma.
Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function.
Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β.
Pseudomonas aeruginosa-induced apoptosis in airway epithelial cells is mediated by gap junctional communication in a JNK-dependent manner.
Endoplasmic reticulum stress in amelogenesis imperfecta and phenotypic rescue using 4-phenylbutyrate.
Germline quality control: eEF2K stands guard to eliminate defective oocytes.
Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers.
mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress.
LMO4 functions as a negative regulator of sensory organ formation in the mammalian cochlea.
Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling.
Mechanism of cystogenesis in nephrotic kidneys: a histopathological study.
Biphasic influence of Miz1 on neural crest development by regulating cell survival and apical adhesion complex formation in the developing neural tube.
Dysregulated STAT1-SOCS1 control of JAK2 promotes mammary luminal progenitor cell survival and drives ERα(+) tumorigenesis.
The extracellular matrix glycoprotein tenascin-R regulates neurogenesis during development and in the adult dentate gyrus of mice.
Antigen dependently activated cluster of differentiation 8-positive T cells cause perforin-mediated neurotoxicity in experimental stroke.
Essential role for the TRF2 telomere protein in adult skin homeostasis.
Diet-induced obesity exacerbates auditory degeneration via hypoxia, inflammation, and apoptosis signaling pathways in CD/1 mice.
Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-κB and Src protein kinase signaling pathways.
Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death.
A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.
The temporal and spatial profiles of cell loss following experimental spinal cord injury: effect of antioxidant therapy on cell death and functional recovery.
Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals.
Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages.
Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid.
Increased chondrocyte apoptosis is associated with progression of osteoarthritis in spontaneous Guinea pig models of the disease.
Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis.
Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy.
An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration.
Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation.
Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain.
Two hypomorphic alleles of mouse Ass1 as a new animal model of citrullinemia type I and other hyperammonemic syndromes.
MicroRNA-183 family members regulate sensorineural fates in the inner ear.
Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth.
Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death.
ALK1 signaling regulates early postnatal lymphatic vessel development.
Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain.
Mitogen-activated protein kinase-signaling regulates the ability of Müller glia to proliferate and protect retinal neurons against excitotoxicity.
Repeated ethanol exposure during late gestation alters the maturation and innate immune status of the ovine fetal lung.
Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease.
A functional interaction between Irx and Meis patterns the anterior hindbrain and activates krox20 expression in rhombomere 3.
Cisplatin-resistant neuroblastoma cells express enhanced levels of epidermal growth factor receptor (EGFR) and are sensitive to treatment with EGFR-specific toxins.
Cystic fibrosis transmembrane conductance regulator controls lung proteasomal degradation and nuclear factor-kappaB activity in conditions of oxidative stress.
The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.
Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres.
Cytotoxic action of phorbol esters on human pancreatic cancer cells.
Protein C is an autocrine growth factor for human skin keratinocytes.
Gam1-associated alterations of drug responsiveness through activation of apoptosis.
Cytochemical and ultrastructural study of anoikis and secondary necrosis in enterocytes detached in vivo.
Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep.
Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene.
Tendon-muscle crosstalk controls muscle bellies morphogenesis, which is mediated by cell death and retinoic acid signaling.
Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis.
Invasive trophoblasts stimulate vascular smooth muscle cell apoptosis by a fas ligand-dependent mechanism.
Canonical notch signaling functions as a commitment switch in the epidermal lineage.
Evolution of the androgen receptor pathway during progression of prostate cancer.
Wnt signals mediate a fate decision between otic placode and epidermis.
Mechanisms of apoptosis after ischemia and reperfusion: role of the renin-angiotensin system.
Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice.
Helicobacter felis and Helicobacter bizzozeronii induce gastric parietal cell loss in Mongolian gerbils.
Expression and functional analysis of Bax inhibitor-1 in human breast cancer cells.
Involvement of the Edar signaling in the control of hair follicle involution (catagen).
Higher resistance of porcine trigeminal ganglion neurons towards pseudorabies virus-induced cell death compared with other porcine cell types in vitro.
The pseudorabies virus US3 protein kinase possesses anti-apoptotic activity that protects cells from apoptosis during infection and after treatment with sorbitol or staurosporine.
Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block.
Apoptosis and active caspase-3 expression in human granulosa cells.
Effects of systemically administered NT-3 on sensory neuron loss and nestin expression following axotomy.
Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation.
Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation.
Lactate dehydrogenase-elevating virus induces apoptosis in cultured macrophages and in spinal cords of C58 mice coincident with onset of murine amyotrophic lateral sclerosis.
Analysis of central regulatory pathways in p53-deficient primary cultures of malignant fibrous histiocytoma exposed to ifosfamide.
Blockade of the type I IGF receptor expression in human prostate cancer cells inhibits proliferation and invasion, up-regulates IGF binding protein-3, and suppresses MMP-2 expression.
Evidence of caspase-3 activation in hyposmotic stress-induced necrosis.
Early events in the anoikis program occur in the absence of caspase activation.
Aprile D, Fruscione F, Baldassari S, Fadda M, Ferrante D, Falace A, Buhler E, Sartorelli J, Represa A, Baldelli P, Benfenati F, Zara F, Fassio A
Cell death and differentiation 2019 Nov;26(11):2464-2478
Cell death and differentiation 2019 Nov;26(11):2464-2478
SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating β-Catenin Nuclear Localization.
Antas P, Novellasdemunt L, Kucharska A, Massie I, Carvalho J, Oukrif D, Nye E, Novelli M, Li VSW
Cell reports 2019 Feb 26;26(9):2266-2273.e4
Cell reports 2019 Feb 26;26(9):2266-2273.e4
Loss of Ccbe1 affects cardiac-specification and cardiomyocyte differentiation in mouse embryonic stem cells.
Bover O, Justo T, Pereira PNG, Facucho-Oliveira J, Inácio JM, Ramalho JS, Domian IJ, Belo JA
PloS one 2018;13(10):e0205108
PloS one 2018;13(10):e0205108
Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells.
Dreyer-Andersen N, Almeida AS, Jensen P, Kamand M, Okarmus J, Rosenberg T, Friis SD, Martínez Serrano A, Blaabjerg M, Kristensen BW, Skrydstrup T, Gramsbergen JB, Vieira HLA, Meyer M
PloS one 2018;13(1):e0191207
PloS one 2018;13(1):e0191207
The protective effects of total paeony glycoside on ischemia/reperfusion injury in H9C2 cells via inhibition of the PI3K/Akt signaling pathway.
Shen P, Chen J, Pan M
Molecular medicine reports 2018 Sep;18(3):3332-3340
Molecular medicine reports 2018 Sep;18(3):3332-3340
Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation.
Zwick RK, Rudolph MC, Shook BA, Holtrup B, Roth E, Lei V, Van Keymeulen A, Seewaldt V, Kwei S, Wysolmerski J, Rodeheffer MS, Horsley V
Nature communications 2018 Sep 4;9(1):3592
Nature communications 2018 Sep 4;9(1):3592
PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification.
Cohen I, Zhao D, Bar C, Valdes VJ, Dauber-Decker KL, Nguyen MB, Nakayama M, Rendl M, Bickmore WA, Koseki H, Zheng D, Ezhkova E
Cell stem cell 2018 May 3;22(5):726-739.e7
Cell stem cell 2018 May 3;22(5):726-739.e7
Tracking cellular and molecular changes in a species-specific manner during experimental tumor progression in vivo.
Indersie E, Hooks KB, Capdevielle C, Fabre M, Dugot-Senant N, Desplat A, Lepreux S, Merched A, Grosset CF, Hagedorn M
Oncotarget 2018 Mar 23;9(22):16149-16162
Oncotarget 2018 Mar 23;9(22):16149-16162
Intracellular attenuation of BMP signaling via CKIP-1/Smurf1 is essential during neural crest induction.
Piacentino ML, Bronner ME
PLoS biology 2018 Jun;16(6):e2004425
PLoS biology 2018 Jun;16(6):e2004425
Epidermal-specific deletion of TC-PTP promotes UVB-induced epidermal cell survival through the regulation of Flk-1/JNK signaling.
Baek M, Kim M, Lim JS, Morales LD, Hernandez J, Mummidi S, Williams-Blangero S, Jang IS, Tsin AT, Kim DJ
Cell death & disease 2018 Jun 28;9(7):730
Cell death & disease 2018 Jun 28;9(7):730
Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres.
Povedano JM, Martinez P, Serrano R, Tejera Á, Gómez-López G, Bobadilla M, Flores JM, Bosch F, Blasco MA
eLife 2018 Jan 30;7
eLife 2018 Jan 30;7
KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS.
Ambrogio C, Köhler J, Zhou ZW, Wang H, Paranal R, Li J, Capelletti M, Caffarra C, Li S, Lv Q, Gondi S, Hunter JC, Lu J, Chiarle R, Santamaría D, Westover KD, Jänne PA
Cell 2018 Feb 8;172(4):857-868.e15
Cell 2018 Feb 8;172(4):857-868.e15
A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway.
Antoniou N, Vlachakis D, Memou A, Leandrou E, Valkimadi PE, Melachroinou K, Re DB, Przedborski S, Dauer WT, Stefanis L, Rideout HJ
Scientific reports 2018 Feb 22;8(1):3455
Scientific reports 2018 Feb 22;8(1):3455
BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer.
Ouarné M, Bouvard C, Boneva G, Mallet C, Ribeiro J, Desroches-Castan A, Soleilhac E, Tillet E, Peyruchaud O, Bailly S
Journal of experimental & clinical cancer research : CR 2018 Aug 30;37(1):209
Journal of experimental & clinical cancer research : CR 2018 Aug 30;37(1):209
An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages.
López-Muñoz A, Nicolás FE, García-Moreno D, Pérez-Oliva AB, Navarro-Mendoza MI, Hernández-Oñate MA, Herrera-Estrella A, Torres-Martínez S, Ruiz-Vázquez RM, Garre V, Mulero V
Scientific reports 2018 Aug 24;8(1):12802
Scientific reports 2018 Aug 24;8(1):12802
The kallikrein-Kinin system modulates the progression of colorectal liver metastases in a mouse model.
da Costa PLN, Wynne D, Fifis T, Nguyen L, Perini M, Christophi C
BMC cancer 2018 Apr 4;18(1):382
BMC cancer 2018 Apr 4;18(1):382
Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice.
Barbieri R, Contestabile A, Ciardo MG, Forte N, Marte A, Baldelli P, Benfenati F, Onofri F
Oncotarget 2018 Apr 10;9(27):18760-18774
Oncotarget 2018 Apr 10;9(27):18760-18774
Oxidative damage and impairment of protein quality control systems in keratinocytes exposed to a volatile organic compounds cocktail.
Dezest M, Le Bechec M, Chavatte L, Desauziers V, Chaput B, Grolleau JL, Descargues P, Nizard C, Schnebert S, Lacombe S, Bulteau AL
Scientific reports 2017 Sep 6;7(1):10707
Scientific reports 2017 Sep 6;7(1):10707
The Process of Engraftment of Myogenic Cells in Skeletal Muscles of Primates: Understanding Clinical Observations and Setting Directions in Cell Transplantation Research.
Skuk D, Tremblay JP
Cell transplantation 2017 Nov;26(11):1763-1779
Cell transplantation 2017 Nov;26(11):1763-1779
Caspase-3/-7-Specific Metabolic Precursor for Bioorthogonal Tracking of Tumor Apoptosis.
Shim MK, Yoon HY, Lee S, Jo MK, Park J, Kim JH, Jeong SY, Kwon IC, Kim K
Scientific reports 2017 Nov 30;7(1):16635
Scientific reports 2017 Nov 30;7(1):16635
Low Dose Radiation Causes Skin Cancer in Mice and Has a Differential Effect on Distinct Epidermal Stem Cells.
Revenco T, Lapouge G, Moers V, Brohée S, Sotiropoulou PA
Stem cells (Dayton, Ohio) 2017 May;35(5):1355-1364
Stem cells (Dayton, Ohio) 2017 May;35(5):1355-1364
Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium.
Murray LA, Dunmore R, Camelo A, Da Silva CA, Gustavsson MJ, Habiel DM, Hackett TL, Hogaboam CM, Sleeman MA, Knight DA
Respiratory research 2017 May 3;18(1):82
Respiratory research 2017 May 3;18(1):82
A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin.
Oozeer F, Yates LL, Dean C, Formstone CJ
Scientific reports 2017 May 12;7(1):1880
Scientific reports 2017 May 12;7(1):1880
The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries.
Grasso S, Chapelle J, Salemme V, Aramu S, Russo I, Vitale N, Verdun di Cantogno L, Dallaglio K, Castellano I, Amici A, Centonze G, Sharma N, Lunardi S, Cabodi S, Cavallo F, Lamolinara A, Stramucci L, Moiso E, Provero P, Albini A, Sapino A, Staaf J, Di Fiore PP, Bertalot G, Pece S, Tosoni D, Confalonieri S, Iezzi M, Di Stefano P, Turco E, Defilippi P
Nature communications 2017 Mar 16;8:14797
Nature communications 2017 Mar 16;8:14797
Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth.
Klein JC, Moses K, Zelinskyy G, Sody S, Buer J, Lang S, Helfrich I, Dittmer U, Kirschning CJ, Brandau S
Nature communications 2017 Mar 16;8:14600
Nature communications 2017 Mar 16;8:14600
VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis.
Jang JY, Choi SY, Park I, Park DY, Choe K, Kim P, Kim YK, Lee BJ, Hirashima M, Kubota Y, Park JW, Cheng SY, Nagy A, Park YJ, Alitalo K, Shong M, Koh GY
EMBO molecular medicine 2017 Jun;9(6):750-769
EMBO molecular medicine 2017 Jun;9(6):750-769
New tumor suppressor microRNAs target glypican-3 in human liver cancer.
Cartier F, Indersie E, Lesjean S, Charpentier J, Hooks KB, Ghousein A, Desplat A, Dugot-Senant N, Trézéguet V, Sagliocco F, Hagedorn M, Grosset CF
Oncotarget 2017 Jun 20;8(25):41211-41226
Oncotarget 2017 Jun 20;8(25):41211-41226
Constitutive WNT/CTNNB1 activation triggers spermatogonial stem cell proliferation and germ cell depletion.
Chassot AA, Le Rolle M, Jourden M, Taketo MM, Ghyselinck NB, Chaboissier MC
Developmental biology 2017 Jun 1;426(1):17-27
Developmental biology 2017 Jun 1;426(1):17-27
Bifidobacterium breve reduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD88-dependent manner.
Hughes KR, Harnisch LC, Alcon-Giner C, Mitra S, Wright CJ, Ketskemety J, van Sinderen D, Watson AJ, Hall LJ
Open biology 2017 Jan;7(1)
Open biology 2017 Jan;7(1)
Proliferation, differentiation and migration of SCA1-/CD31- cardiac side population cells in vitro and in vivo.
Wang XZ, Gao RL, Sun P, Liu S, Xu Y, Liang DZ, Yin LM, Phillips WD, Liang SX
International journal of cardiology 2017 Jan 15;227:378-386
International journal of cardiology 2017 Jan 15;227:378-386
Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary.
De Cian MC, Pauper E, Bandiera R, Vidal VP, Sacco S, Gregoire EP, Chassot AA, Panzolini C, Wilhelm D, Pailhoux E, Youssef SA, de Bruin A, Teerds K, Schedl A, Gillot I, Chaboissier MC
Oncogene 2017 Jan 12;36(2):208-218
Oncogene 2017 Jan 12;36(2):208-218
Combined effects of atorvastatin and aspirin on growth and apoptosis in human prostate cancer cells.
He Y, Huang H, Farischon C, Li D, Du Z, Zhang K, Zheng X, Goodin S
Oncology reports 2017 Feb;37(2):953-960
Oncology reports 2017 Feb;37(2):953-960
Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression.
Lyon CA, Williams H, Bianco R, Simmonds SJ, Brown BA, Wadey KS, Smith FCT, Johnson JL, George SJ
Scientific reports 2017 Dec 11;7(1):17342
Scientific reports 2017 Dec 11;7(1):17342
Glycogen synthase kinase-3 inhibition sensitizes human induced pluripotent stem cells to thiol-containing antioxidants induced apoptosis.
Tu C, Xu R, Koleti M, Zoldan J
Stem cell research 2017 Aug;23:182-187
Stem cell research 2017 Aug;23:182-187
Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo.
Flanagan DJ, Barker N, Nowell C, Clevers H, Ernst M, Phesse TJ, Vincan E
Disease models & mechanisms 2017 Aug 1;10(8):971-980
Disease models & mechanisms 2017 Aug 1;10(8):971-980
Autophagy deficient keratinocytes display increased DNA damage, senescence and aberrant lipid composition after oxidative stress in vitro and in vivo.
Song X, Narzt MS, Nagelreiter IM, Hohensinner P, Terlecki-Zaniewicz L, Tschachler E, Grillari J, Gruber F
Redox biology 2017 Apr;11:219-230
Redox biology 2017 Apr;11:219-230
Brinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density.
Berkowicz SR, Featherby TJ, Qu Z, Giousoh A, Borg NA, Heng JI, Whisstock JC, Bird PI
Molecular autism 2016;7:22
Molecular autism 2016;7:22
Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture.
Lorenzi F, Babaei-Jadidi R, Sheard J, Spencer-Dene B, Nateri AS
Molecular therapy. Methods & clinical development 2016;3:16024
Molecular therapy. Methods & clinical development 2016;3:16024
Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue.
Jacob F, Yonis AY, Cuello F, Luther P, Schulze T, Eder A, Streichert T, Mannhardt I, Hirt MN, Schaaf S, Stenzig J, Force T, Eschenhagen T, Hansen A
PloS one 2016;11(2):e0145937
PloS one 2016;11(2):e0145937
Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations.
Melachroinou K, Leandrou E, Valkimadi PE, Memou A, Hadjigeorgiou G, Stefanis L, Rideout HJ
PloS one 2016;11(11):e0166053
PloS one 2016;11(11):e0166053
Axonal Cleaved Caspase-3 Regulates Axon Targeting and Morphogenesis in the Developing Auditory Brainstem.
Rotschafer SE, Allen-Sharpley MR, Cramer KS
Frontiers in neural circuits 2016;10:84
Frontiers in neural circuits 2016;10:84
An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress.
Quereda V, Porlan E, Cañamero M, Dubus P, Malumbres M
Cell death and differentiation 2016 Mar;23(3):430-41
Cell death and differentiation 2016 Mar;23(3):430-41
Cord blood mononuclear cells prevent neuronal apoptosis in response to perinatal asphyxia in the newborn lamb.
Aridas JD, McDonald CA, Paton MC, Yawno T, Sutherland AE, Nitsos I, Pham Y, Ditchfield M, Fahey MC, Wong F, Malhotra A, Castillo-Melendez M, Bhakoo K, Wallace EM, Jenkin G, Miller SL
The Journal of physiology 2016 Mar 1;594(5):1421-35
The Journal of physiology 2016 Mar 1;594(5):1421-35
Defining the cellular lineage hierarchy in the interfollicular epidermis of adult skin.
Sada A, Jacob F, Leung E, Wang S, White BS, Shalloway D, Tumbar T
Nature cell biology 2016 Jun;18(6):619-31
Nature cell biology 2016 Jun;18(6):619-31
CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex.
Abdullah AI, Zhang H, Nie Y, Tang W, Sun T
Stem cell reports 2016 Jul 12;7(1):69-79
Stem cell reports 2016 Jul 12;7(1):69-79
cMyc Regulates the Size of the Premigratory Neural Crest Stem Cell Pool.
Kerosuo L, Bronner ME
Cell reports 2016 Dec 6;17(10):2648-2659
Cell reports 2016 Dec 6;17(10):2648-2659
Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice.
Rainey RN, Ng SY, Llamas J, van der Horst GT, Segil N
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Apr 27;36(17):4758-70
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Apr 27;36(17):4758-70
Attenuation of Cerebral Ischemic Injury in Smad1 Deficient Mice.
Wong JK, Chen L, Huang Y, Sehba FA, Friedel RH, Zou H
PloS one 2015;10(8):e0136967
PloS one 2015;10(8):e0136967
Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response.
Sesen J, Dahan P, Scotland SJ, Saland E, Dang VT, Lemarié A, Tyler BM, Brem H, Toulas C, Cohen-Jonathan Moyal E, Sarry JE, Skuli N
PloS one 2015;10(4):e0123721
PloS one 2015;10(4):e0123721
Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer.
Brindle NR, Joyce JA, Rostker F, Lawlor ER, Swigart-Brown L, Evan G, Hanahan D, Shchors K
PloS one 2015;10(4):e0120348
PloS one 2015;10(4):e0120348
Hepatocyte-specific deletion of ARNT (aryl hydrocarbon Receptor Nuclear Translocator) results in altered fibrotic gene expression in the thioacetamide model of liver injury.
Scott C, Cha K, Rao R, Liddle C, George J, Gunton JE
PloS one 2015;10(3):e0121650
PloS one 2015;10(3):e0121650
Preclinical studies identify non-apoptotic low-level caspase-3 as therapeutic target in pemphigus vulgaris.
Luyet C, Schulze K, Sayar BS, Howald D, Müller EJ, Galichet A
PloS one 2015;10(3):e0119809
PloS one 2015;10(3):e0119809
Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a ∆133p53α mimic.
Sawhney S, Hood K, Shaw A, Braithwaite AW, Stubbs R, Hung NA, Royds JA, Slatter TL
PloS one 2015;10(2):e0116270
PloS one 2015;10(2):e0116270
Apoptosis-Related Factors in the Luteal Phase of the Domestic Cat and Their Involvement in the Persistence of Corpora Lutea in Lynx.
Amelkina O, Zschockelt L, Painer J, Serra R, Villaespesa F, Braun BC, Jewgenow K
PloS one 2015;10(11):e0143414
PloS one 2015;10(11):e0143414
The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice.
Douglas T, Champagne C, Morizot A, Lapointe JM, Saleh M
Journal of immunology (Baltimore, Md. : 1950) 2015 Sep 1;195(5):2365-73
Journal of immunology (Baltimore, Md. : 1950) 2015 Sep 1;195(5):2365-73
TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.
Matsuda T, Murao N, Katano Y, Juliandi B, Kohyama J, Akira S, Kawai T, Nakashima K
Nature communications 2015 Mar 9;6:6514
Nature communications 2015 Mar 9;6:6514
Interactions of highly and low virulent Flavobacterium columnare isolates with gill tissue in carp and rainbow trout.
Declercq AM, Chiers K, Van den Broeck W, Dewulf J, Eeckhaut V, Cornelissen M, Bossier P, Haesebrouck F, Decostere A
Veterinary research 2015 Mar 6;46:25
Veterinary research 2015 Mar 6;46:25
BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus.
Levet S, Ouarné M, Ciais D, Coutton C, Subileau M, Mallet C, Ricard N, Bidart M, Debillon T, Faravelli F, Rooryck C, Feige JJ, Tillet E, Bailly S
Proceedings of the National Academy of Sciences of the United States of America 2015 Jun 23;112(25):E3207-15
Proceedings of the National Academy of Sciences of the United States of America 2015 Jun 23;112(25):E3207-15
Exacerbated experimental colitis in TNFAIP8-deficient mice.
Sun H, Lou Y, Porturas T, Morrissey S, Luo G, Qi J, Ruan Q, Shi S, Chen YH
Journal of immunology (Baltimore, Md. : 1950) 2015 Jun 15;194(12):5736-42
Journal of immunology (Baltimore, Md. : 1950) 2015 Jun 15;194(12):5736-42
Pulmonary alveolar macrophages contribute to the premetastatic niche by suppressing antitumor T cell responses in the lungs.
Sharma SK, Chintala NK, Vadrevu SK, Patel J, Karbowniczek M, Markiewski MM
Journal of immunology (Baltimore, Md. : 1950) 2015 Jun 1;194(11):5529-38
Journal of immunology (Baltimore, Md. : 1950) 2015 Jun 1;194(11):5529-38
Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration.
Moyon S, Dubessy AL, Aigrot MS, Trotter M, Huang JK, Dauphinot L, Potier MC, Kerninon C, Melik Parsadaniantz S, Franklin RJ, Lubetzki C
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jan 7;35(1):4-20
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jan 7;35(1):4-20
Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours.
Petersson M, Reuter K, Brylka H, Kraus A, Schettina P, Niemann C
Nature communications 2015 Jan 22;6:5874
Nature communications 2015 Jan 22;6:5874
Epidermal growth factor attenuates tubular necrosis following mercuric chloride damage by regeneration of indigenous, not bone marrow-derived cells.
Yen TH, Alison MR, Goodlad RA, Otto WR, Jeffery R, Cook HT, Wright NA, Poulsom R
Journal of cellular and molecular medicine 2015 Feb;19(2):463-73
Journal of cellular and molecular medicine 2015 Feb;19(2):463-73
Differential sensitivity of prefrontal cortex and hippocampus to alcohol-induced toxicity.
Fowler AK, Thompson J, Chen L, Dagda M, Dertien J, Dossou KS, Moaddel R, Bergeson SE, Kruman II
PloS one 2014;9(9):e106945
PloS one 2014;9(9):e106945
Short term morphine exposure in vitro alters proliferation and differentiation of neural progenitor cells and promotes apoptosis via mu receptors.
Willner D, Cohen-Yeshurun A, Avidan A, Ozersky V, Shohami E, Leker RR
PloS one 2014;9(7):e103043
PloS one 2014;9(7):e103043
Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity.
Park DY, Lee J, Park I, Choi D, Lee S, Song S, Hwang Y, Hong KY, Nakaoka Y, Makinen T, Kim P, Alitalo K, Hong YK, Koh GY
The Journal of clinical investigation 2014 Sep;124(9):3960-74
The Journal of clinical investigation 2014 Sep;124(9):3960-74
Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma.
Lindgren G, Ekblad L, Vallon-Christersson J, Kjellén E, Gebre-Medhin M, Wennerberg J
BMC cancer 2014 Sep 2;14:648
BMC cancer 2014 Sep 2;14:648
Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function.
Kumar L, Chou J, Yee CS, Borzutzky A, Vollmann EH, von Andrian UH, Park SY, Hollander G, Manis JP, Poliani PL, Geha RS
The Journal of experimental medicine 2014 May 5;211(5):929-42
The Journal of experimental medicine 2014 May 5;211(5):929-42
Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β.
Wiener Z, Band AM, Kallio P, Högström J, Hyvönen V, Kaijalainen S, Ritvos O, Haglund C, Kruuna O, Robine S, Louvard D, Ben-Neriah Y, Alitalo K
Proceedings of the National Academy of Sciences of the United States of America 2014 May 27;111(21):E2229-36
Proceedings of the National Academy of Sciences of the United States of America 2014 May 27;111(21):E2229-36
Pseudomonas aeruginosa-induced apoptosis in airway epithelial cells is mediated by gap junctional communication in a JNK-dependent manner.
Losa D, Köhler T, Bellec J, Dudez T, Crespin S, Bacchetta M, Boulanger P, Hong SS, Morel S, Nguyen TH, van Delden C, Chanson M
Journal of immunology (Baltimore, Md. : 1950) 2014 May 15;192(10):4804-12
Journal of immunology (Baltimore, Md. : 1950) 2014 May 15;192(10):4804-12
Endoplasmic reticulum stress in amelogenesis imperfecta and phenotypic rescue using 4-phenylbutyrate.
Brookes SJ, Barron MJ, Boot-Handford R, Kirkham J, Dixon MJ
Human molecular genetics 2014 May 1;23(9):2468-80
Human molecular genetics 2014 May 1;23(9):2468-80
Germline quality control: eEF2K stands guard to eliminate defective oocytes.
Chu HP, Liao Y, Novak JS, Hu Z, Merkin JJ, Shymkiv Y, Braeckman BP, Dorovkov MV, Nguyen A, Clifford PM, Nagele RG, Harrison DE, Ellis RE, Ryazanov AG
Developmental cell 2014 Mar 10;28(5):561-572
Developmental cell 2014 Mar 10;28(5):561-572
Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers.
Edlund RK, Ohyama T, Kantarci H, Riley BB, Groves AK
Developmental biology 2014 Jun 1;390(1):1-13
Developmental biology 2014 Jun 1;390(1):1-13
mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress.
Grahammer F, Haenisch N, Steinhardt F, Sandner L, Roerden M, Arnold F, Cordts T, Wanner N, Reichardt W, Kerjaschki D, Ruegg MA, Hall MN, Moulin P, Busch H, Boerries M, Walz G, Artunc F, Huber TB
Proceedings of the National Academy of Sciences of the United States of America 2014 Jul 8;111(27):E2817-26
Proceedings of the National Academy of Sciences of the United States of America 2014 Jul 8;111(27):E2817-26
LMO4 functions as a negative regulator of sensory organ formation in the mammalian cochlea.
Deng M, Luo XJ, Pan L, Yang H, Xie X, Liang G, Huang L, Hu F, Kiernan AE, Gan L
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Jul 23;34(30):10072-7
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Jul 23;34(30):10072-7
Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling.
Fan J, Ponferrada VG, Sato T, Vemaraju S, Fruttiger M, Gerhardt H, Ferrara N, Lang RA
Development (Cambridge, England) 2014 Jan;141(2):448-59
Development (Cambridge, England) 2014 Jan;141(2):448-59
Mechanism of cystogenesis in nephrotic kidneys: a histopathological study.
Saraga M, Vukojević K, Krželj V, Puretić Z, Bočina I, Durdov MG, Weber S, Dworniczak B, Ljubanović DG, Saraga-Babić M
BMC nephrology 2014 Jan 8;15:3
BMC nephrology 2014 Jan 8;15:3
Biphasic influence of Miz1 on neural crest development by regulating cell survival and apical adhesion complex formation in the developing neural tube.
Kerosuo L, Bronner ME
Molecular biology of the cell 2014 Feb;25(3):347-55
Molecular biology of the cell 2014 Feb;25(3):347-55
Dysregulated STAT1-SOCS1 control of JAK2 promotes mammary luminal progenitor cell survival and drives ERα(+) tumorigenesis.
Chan SR, Rickert CG, Vermi W, Sheehan KC, Arthur C, Allen JA, White JM, Archambault J, Lonardi S, McDevitt TM, Bhattacharya D, Lorenzi MV, Allred DC, Schreiber RD
Cell death and differentiation 2014 Feb;21(2):234-46
Cell death and differentiation 2014 Feb;21(2):234-46
The extracellular matrix glycoprotein tenascin-R regulates neurogenesis during development and in the adult dentate gyrus of mice.
Xu JC, Xiao MF, Jakovcevski I, Sivukhina E, Hargus G, Cui YF, Irintchev A, Schachner M, Bernreuther C
Journal of cell science 2014 Feb 1;127(Pt 3):641-52
Journal of cell science 2014 Feb 1;127(Pt 3):641-52
Antigen dependently activated cluster of differentiation 8-positive T cells cause perforin-mediated neurotoxicity in experimental stroke.
Mracsko E, Liesz A, Stojanovic A, Lou WP, Osswald M, Zhou W, Karcher S, Winkler F, Martin-Villalba A, Cerwenka A, Veltkamp R
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Dec 10;34(50):16784-95
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Dec 10;34(50):16784-95
Essential role for the TRF2 telomere protein in adult skin homeostasis.
Martínez P, Ferrara-Romeo I, Flores JM, Blasco MA
Aging cell 2014 Aug;13(4):656-68
Aging cell 2014 Aug;13(4):656-68
Diet-induced obesity exacerbates auditory degeneration via hypoxia, inflammation, and apoptosis signaling pathways in CD/1 mice.
Hwang JH, Hsu CJ, Yu WH, Liu TC, Yang WS
PloS one 2013;8(4):e60730
PloS one 2013;8(4):e60730
Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-κB and Src protein kinase signaling pathways.
Shakibaei M, Mobasheri A, Lueders C, Busch F, Shayan P, Goel A
PloS one 2013;8(2):e57218
PloS one 2013;8(2):e57218
Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death.
Wahlin KJ, Enke RA, Fuller JA, Kalesnykas G, Zack DJ, Merbs SL
PloS one 2013;8(11):e79140
PloS one 2013;8(11):e79140
A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.
Olive V, Sabio E, Bennett MJ, De Jong CS, Biton A, McGann JC, Greaney SK, Sodir NM, Zhou AY, Balakrishnan A, Foth M, Luftig MA, Goga A, Speed TP, Xuan Z, Evan GI, Wan Y, Minella AC, He L
eLife 2013 Oct 15;2:e00822
eLife 2013 Oct 15;2:e00822
The temporal and spatial profiles of cell loss following experimental spinal cord injury: effect of antioxidant therapy on cell death and functional recovery.
Ling X, Bao F, Qian H, Liu D
BMC neuroscience 2013 Nov 18;14:146
BMC neuroscience 2013 Nov 18;14:146
Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals.
Pérez de Castro I, Aguirre-Portolés C, Fernández-Miranda G, Cañamero M, Cowley DO, Van Dyke T, Malumbres M
Cancer research 2013 Nov 15;73(22):6804-15
Cancer research 2013 Nov 15;73(22):6804-15
Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages.
Stott SR, Metzakopian E, Lin W, Kaestner KH, Hen R, Ang SL
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 May 1;33(18):8022-34
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 May 1;33(18):8022-34
Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid.
Tzeng TT, Tsay HJ, Chang L, Hsu CL, Lai TH, Huang FL, Shiao YJ
Journal of biomedical science 2013 Dec 6;20:90
Journal of biomedical science 2013 Dec 6;20:90
Increased chondrocyte apoptosis is associated with progression of osteoarthritis in spontaneous Guinea pig models of the disease.
Zamli Z, Adams MA, Tarlton JF, Sharif M
International journal of molecular sciences 2013 Aug 29;14(9):17729-43
International journal of molecular sciences 2013 Aug 29;14(9):17729-43
Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis.
Demidov ON, Zhu Y, Kek C, Goloudina AR, Motoyama N, Bulavin DV
Cell death and differentiation 2012 Nov;19(11):1761-8
Cell death and differentiation 2012 Nov;19(11):1761-8
Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy.
McIntyre A, Patiar S, Wigfield S, Li JL, Ledaki I, Turley H, Leek R, Snell C, Gatter K, Sly WS, Vaughan-Jones RD, Swietach P, Harris AL
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Jun 1;18(11):3100-11
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Jun 1;18(11):3100-11
An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration.
Chen T, Heller E, Beronja S, Oshimori N, Stokes N, Fuchs E
Nature 2012 Apr 4;485(7396):104-8
Nature 2012 Apr 4;485(7396):104-8
Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation.
Fuxe J, Tabruyn S, Colton K, Zaid H, Adams A, Baluk P, Lashnits E, Morisada T, Le T, O'Brien S, Epstein DM, Koh GY, McDonald DM
The American journal of pathology 2011 Jun;178(6):2897-909
The American journal of pathology 2011 Jun;178(6):2897-909
Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain.
Hernández-Miranda LR, Cariboni A, Faux C, Ruhrberg C, Cho JH, Cloutier JF, Eickholt BJ, Parnavelas JG, Andrews WD
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Apr 20;31(16):6174-87
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Apr 20;31(16):6174-87
Two hypomorphic alleles of mouse Ass1 as a new animal model of citrullinemia type I and other hyperammonemic syndromes.
Perez CJ, Jaubert J, Guénet JL, Barnhart KF, Ross-Inta CM, Quintanilla VC, Aubin I, Brandon JL, Otto NW, DiGiovanni J, Gimenez-Conti I, Giulivi C, Kusewitt DF, Conti CJ, Benavides F
The American journal of pathology 2010 Oct;177(4):1958-68
The American journal of pathology 2010 Oct;177(4):1958-68
MicroRNA-183 family members regulate sensorineural fates in the inner ear.
Li H, Kloosterman W, Fekete DM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Mar 3;30(9):3254-63
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Mar 3;30(9):3254-63
Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth.
Hashizume H, Falcón BL, Kuroda T, Baluk P, Coxon A, Yu D, Bready JV, Oliner JD, McDonald DM
Cancer research 2010 Mar 15;70(6):2213-23
Cancer research 2010 Mar 15;70(6):2213-23
Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death.
Sotiropoulou PA, Candi A, Mascré G, De Clercq S, Youssef KK, Lapouge G, Dahl E, Semeraro C, Denecker G, Marine JC, Blanpain C
Nature cell biology 2010 Jun;12(6):572-82
Nature cell biology 2010 Jun;12(6):572-82
ALK1 signaling regulates early postnatal lymphatic vessel development.
Niessen K, Zhang G, Ridgway JB, Chen H, Yan M
Blood 2010 Feb 25;115(8):1654-61
Blood 2010 Feb 25;115(8):1654-61
Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain.
Yawno T, Hirst JJ, Castillo-Melendez M, Walker DW
Neuroscience 2009 Oct 20;163(3):838-47
Neuroscience 2009 Oct 20;163(3):838-47
Mitogen-activated protein kinase-signaling regulates the ability of Müller glia to proliferate and protect retinal neurons against excitotoxicity.
Fischer AJ, Scott MA, Ritchey ER, Sherwood P
Glia 2009 Nov 1;57(14):1538-52
Glia 2009 Nov 1;57(14):1538-52
Repeated ethanol exposure during late gestation alters the maturation and innate immune status of the ovine fetal lung.
Sozo F, O'Day L, Maritz G, Kenna K, Stacy V, Brew N, Walker D, Bocking A, Brien J, Harding R
American journal of physiology. Lung cellular and molecular physiology 2009 Mar;296(3):L510-8
American journal of physiology. Lung cellular and molecular physiology 2009 Mar;296(3):L510-8
Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease.
Borchers MT, Wesselkamper SC, Curull V, Ramirez-Sarmiento A, Sánchez-Font A, Garcia-Aymerich J, Coronell C, Lloreta J, Agusti AG, Gea J, Howington JA, Reed MF, Starnes SL, Harris NL, Vitucci M, Eppert BL, Motz GT, Fogel K, McGraw DW, Tichelaar JW, Orozco-Levi M
The Journal of clinical investigation 2009 Mar;119(3):636-49
The Journal of clinical investigation 2009 Mar;119(3):636-49
A functional interaction between Irx and Meis patterns the anterior hindbrain and activates krox20 expression in rhombomere 3.
Stedman A, Lecaudey V, Havis E, Anselme I, Wassef M, Gilardi-Hebenstreit P, Schneider-Maunoury S
Developmental biology 2009 Mar 15;327(2):566-77
Developmental biology 2009 Mar 15;327(2):566-77
Cisplatin-resistant neuroblastoma cells express enhanced levels of epidermal growth factor receptor (EGFR) and are sensitive to treatment with EGFR-specific toxins.
Michaelis M, Bliss J, Arnold SC, Hinsch N, Rothweiler F, Deubzer HE, Witt O, Langer K, Doerr HW, Wels WS, Cinatl J Jr
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Oct 15;14(20):6531-7
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Oct 15;14(20):6531-7
Cystic fibrosis transmembrane conductance regulator controls lung proteasomal degradation and nuclear factor-kappaB activity in conditions of oxidative stress.
Boncoeur E, Roque T, Bonvin E, Saint-Criq V, Bonora M, Clement A, Tabary O, Henrion-Caude A, Jacquot J
The American journal of pathology 2008 May;172(5):1184-94
The American journal of pathology 2008 May;172(5):1184-94
The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.
Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Ylä-Herttuala S, Wedge SR, Jürgensmeier JM, Alitalo K
Cancer research 2008 Jun 15;68(12):4754-62
Cancer research 2008 Jun 15;68(12):4754-62
Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres.
Siegl-Cachedenier I, Flores I, Klatt P, Blasco MA
The Journal of cell biology 2007 Oct 22;179(2):277-90
The Journal of cell biology 2007 Oct 22;179(2):277-90
Cytotoxic action of phorbol esters on human pancreatic cancer cells.
Bond JA, Gescher AJ, Verschoyle RD, Lemoine NR, Errington R, Wiltshire M, Smith PJ, Wynford-Thomas D
International journal of cancer 2007 Oct 1;121(7):1445-54
International journal of cancer 2007 Oct 1;121(7):1445-54
Protein C is an autocrine growth factor for human skin keratinocytes.
Xue M, Campbell D, Jackson CJ
The Journal of biological chemistry 2007 May 4;282(18):13610-6
The Journal of biological chemistry 2007 May 4;282(18):13610-6
Gam1-associated alterations of drug responsiveness through activation of apoptosis.
Wu F, Chiocca S, Beck WT, Mo YY
Molecular cancer therapeutics 2007 Jun;6(6):1823-30
Molecular cancer therapeutics 2007 Jun;6(6):1823-30
Cytochemical and ultrastructural study of anoikis and secondary necrosis in enterocytes detached in vivo.
do Vale A, Costa-Ramos C, Silva DS, Macedo PM, Fernandes R, Sampaio P, Dos Santos NM, Silva MT
Apoptosis : an international journal on programmed cell death 2007 Jun;12(6):1069-83
Apoptosis : an international journal on programmed cell death 2007 Jun;12(6):1069-83
Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep.
Yawno T, Yan EB, Walker DW, Hirst JJ
Neuroscience 2007 Jun 8;146(4):1726-33
Neuroscience 2007 Jun 8;146(4):1726-33
Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene.
Blouw B, Haase VH, Song H, Bergers G, Johnson RS
Oncogene 2007 Jul 5;26(31):4531-40
Oncogene 2007 Jul 5;26(31):4531-40
Tendon-muscle crosstalk controls muscle bellies morphogenesis, which is mediated by cell death and retinoic acid signaling.
Rodriguez-Guzman M, Montero JA, Santesteban E, Gañan Y, Macias D, Hurle JM
Developmental biology 2007 Feb 1;302(1):267-80
Developmental biology 2007 Feb 1;302(1):267-80
Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis.
Benosman S, Gross I, Clarke N, Jochemsen AG, Okamoto K, Loeffler JP, Gaiddon C
Cell death and differentiation 2007 Dec;14(12):2047-57
Cell death and differentiation 2007 Dec;14(12):2047-57
Invasive trophoblasts stimulate vascular smooth muscle cell apoptosis by a fas ligand-dependent mechanism.
Harris LK, Keogh RJ, Wareing M, Baker PN, Cartwright JE, Aplin JD, Whitley GS
The American journal of pathology 2006 Nov;169(5):1863-74
The American journal of pathology 2006 Nov;169(5):1863-74
Canonical notch signaling functions as a commitment switch in the epidermal lineage.
Blanpain C, Lowry WE, Pasolli HA, Fuchs E
Genes & development 2006 Nov 1;20(21):3022-35
Genes & development 2006 Nov 1;20(21):3022-35
Evolution of the androgen receptor pathway during progression of prostate cancer.
Hendriksen PJ, Dits NF, Kokame K, Veldhoven A, van Weerden WM, Bangma CH, Trapman J, Jenster G
Cancer research 2006 May 15;66(10):5012-20
Cancer research 2006 May 15;66(10):5012-20
Wnt signals mediate a fate decision between otic placode and epidermis.
Ohyama T, Mohamed OA, Taketo MM, Dufort D, Groves AK
Development (Cambridge, England) 2006 Mar;133(5):865-75
Development (Cambridge, England) 2006 Mar;133(5):865-75
Mechanisms of apoptosis after ischemia and reperfusion: role of the renin-angiotensin system.
Kossmehl P, Kurth E, Faramarzi S, Habighorst B, Shakibaei M, Wehland M, Kreutz R, Infanger M, J Danser AH, Grosse J, Paul M, Grimm D
Apoptosis : an international journal on programmed cell death 2006 Mar;11(3):347-58
Apoptosis : an international journal on programmed cell death 2006 Mar;11(3):347-58
Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice.
Jacomy H, Fragoso G, Almazan G, Mushynski WE, Talbot PJ
Virology 2006 Jun 5;349(2):335-46
Virology 2006 Jun 5;349(2):335-46
Helicobacter felis and Helicobacter bizzozeronii induce gastric parietal cell loss in Mongolian gerbils.
De Bock M, Decostere A, Hellemans A, Haesebrouck F, Ducatelle R
Microbes and infection 2006 Feb;8(2):503-10
Microbes and infection 2006 Feb;8(2):503-10
Expression and functional analysis of Bax inhibitor-1 in human breast cancer cells.
Grzmil M, Kaulfuss S, Thelen P, Hemmerlein B, Schweyer S, Obenauer S, Kang TW, Burfeind P
The Journal of pathology 2006 Feb;208(3):340-9
The Journal of pathology 2006 Feb;208(3):340-9
Involvement of the Edar signaling in the control of hair follicle involution (catagen).
Fessing MY, Sharova TY, Sharov AA, Atoyan R, Botchkarev VA
The American journal of pathology 2006 Dec;169(6):2075-84
The American journal of pathology 2006 Dec;169(6):2075-84
Higher resistance of porcine trigeminal ganglion neurons towards pseudorabies virus-induced cell death compared with other porcine cell types in vitro.
Geenen K, Favoreel HW, Nauwynck HJ
The Journal of general virology 2005 May;86(Pt 5):1251-60
The Journal of general virology 2005 May;86(Pt 5):1251-60
The pseudorabies virus US3 protein kinase possesses anti-apoptotic activity that protects cells from apoptosis during infection and after treatment with sorbitol or staurosporine.
Geenen K, Favoreel HW, Olsen L, Enquist LW, Nauwynck HJ
Virology 2005 Jan 5;331(1):144-50
Virology 2005 Jan 5;331(1):144-50
Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block.
Salomonsson S, Sonesson SE, Ottosson L, Muhallab S, Olsson T, Sunnerhagen M, Kuchroo VK, Thorén P, Herlenius E, Wahren-Herlenius M
The Journal of experimental medicine 2005 Jan 3;201(1):11-7
The Journal of experimental medicine 2005 Jan 3;201(1):11-7
Apoptosis and active caspase-3 expression in human granulosa cells.
Glamoclija V, Vilović K, Saraga-Babić M, Baranović A, Sapunar D
Fertility and sterility 2005 Feb;83(2):426-31
Fertility and sterility 2005 Feb;83(2):426-31
Effects of systemically administered NT-3 on sensory neuron loss and nestin expression following axotomy.
Kuo LT, Simpson A, Schänzer A, Tse J, An SF, Scaravilli F, Groves MJ
The Journal of comparative neurology 2005 Feb 21;482(4):320-32
The Journal of comparative neurology 2005 Feb 21;482(4):320-32
Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation.
Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noël A, Cataldo DD
Journal of immunology (Baltimore, Md. : 1950) 2005 Aug 15;175(4):2589-97
Journal of immunology (Baltimore, Md. : 1950) 2005 Aug 15;175(4):2589-97
Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation.
Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noël A, Cataldo DD
Journal of immunology (Baltimore, Md. : 1950) 2005 Aug 15;175(4):2589-97
Journal of immunology (Baltimore, Md. : 1950) 2005 Aug 15;175(4):2589-97
Lactate dehydrogenase-elevating virus induces apoptosis in cultured macrophages and in spinal cords of C58 mice coincident with onset of murine amyotrophic lateral sclerosis.
Zitterkopf NL, McNeal DW, Eyster KM, Bradley DS, Cafruny WA
Virus research 2004 Nov;106(1):35-42
Virus research 2004 Nov;106(1):35-42
Analysis of central regulatory pathways in p53-deficient primary cultures of malignant fibrous histiocytoma exposed to ifosfamide.
Schlott T, Taubert H, Fayyazi A, Schweyer S, Bartel F, Korabiowska M, Brinck U
Anticancer research 2004 Nov-Dec;24(6):3819-29
Anticancer research 2004 Nov-Dec;24(6):3819-29
Blockade of the type I IGF receptor expression in human prostate cancer cells inhibits proliferation and invasion, up-regulates IGF binding protein-3, and suppresses MMP-2 expression.
Grzmil M, Hemmerlein B, Thelen P, Schweyer S, Burfeind P
The Journal of pathology 2004 Jan;202(1):50-9
The Journal of pathology 2004 Jan;202(1):50-9
Evidence of caspase-3 activation in hyposmotic stress-induced necrosis.
Niquet J, Allen SG, Baldwin RA, Wasterlain CG
Neuroscience letters 2004 Feb 19;356(3):225-7
Neuroscience letters 2004 Feb 19;356(3):225-7
Early events in the anoikis program occur in the absence of caspase activation.
Wang P, Valentijn AJ, Gilmore AP, Streuli CH
The Journal of biological chemistry 2003 May 30;278(22):19917-25
The Journal of biological chemistry 2003 May 30;278(22):19917-25
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Caspase-3 in Jurkat Human Cell Line. Caspase-3 was detected in immersion fixed anti-FAS treated Jurkat human acute T cell leukemia cell line using 0.3 µg/mL Human/Mouse Active Caspase-3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) for 3 hours at room temperature. Cells were stained (red) and counterstained (green). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Caspase-3 in Jurkat Human Cell Line. Caspase-3 was detected in immersion fixed Jurkat human acute T cell leukemia cell line stimulated with staurosporin using Human/Mouse Active Caspase-3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Rabbit IgG Secondary Antibody (yellow; Catalog # NL004) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.
Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Caspase-3 in Human Colon Cancer Tissue. Caspase-3 was detected in immersion fixed paraffin-embedded sections of human colon cancer tissue using Rabbit Anti-Human/Mouse Active Caspase-3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) at 1 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Rabbit IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC003). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.
