CHD3

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Description

Chromodomain helicase DNA binding protein 3

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nucleoli, Centriolar satellite

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (7884796 - 7912760)

Ensembl ID

ENSG00000170004  (ver. 103.38)

Orthologs

Mouse Chd3: ENSMUSG00000018474

UniProt

Q12873

neXtProt

NX_Q12873

Human splice variants
Mouse splice variants

Protein structure