BS7854

antibody from Bioworld Technology, Inc
Targeting: NDEL1 MITAP1, NDE1L1, NDE2, NUDEL
Provider product page for BS7854
Western blot
Immunohistochemistry

Antibody data

Product number
BS7854 - Provider product page
Provider
Bioworld Technology, Inc
Product name
NDEL1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human NDEL1.
Description
NudE-like protein (Ndel1) is expressed in the testis, brain, heart, hypothalamus, liver, lung, spleen, and stomach, specifically in the interphase centrosome and mitotic spindle. It positively regulates minus-end directed dynein. Evidence suggests that Ndel1 interacts with LIS1 to sustain the function of dynein, thereby impacting microtubule organization, nuclear translocation, and neuronal positioning. Ndel1 is phosphorylated during mitosis and seems to tether dynactin and dynein to the mother centriole for microtubule anchoring. Loss of function of Ndel1 in the developing neocortex impairs neuronal positioning and uncouples the centrosome and nucleus. Ndel1 may also impair mitochondrial transport or function, initiating a cascade of events culminating in psychiatric illness such as lissencephaly and schizophrenia.
Reactivity
Human, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
NDEL1 protein structure - BS7854 shown in red.