14742-1-AP

antibody from Proteintech Group

Targeting: UQCRC2 QCR2, UQCR2

Provider product page for 14742-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [70]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 14742-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14742-1-AP, RRID:AB_2241442
Product name: UQCRC2 antibody
Antibody type: Polyclonal
Description: KD/KO validated UQCRC2 antibody (Cat. #14742-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

UQCRC2 protein structure - 14742-1-AP shown in red.

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Peroxiredoxin 3 has a crucial role in the macrophage polarization by regulating mitochondrial homeostasis.

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Nmnat1 Deficiency Causes Mitoribosome Excess in Diabetic Nephropathy Mediated by Transcriptional Repressor HIC1.

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The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.

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Loss of mitochondrial Chchd10 or Chchd2 in zebrafish leads to an ALS-like phenotype and Complex I deficiency independent of the mitochondrial integrated stress response.

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Sleeve Gastrectomy-Induced AMPK Activation Attenuates Diabetic Cardiomyopathy by Maintaining Mitochondrial Homeostasis via NR4A1 Suppression in Rats.

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Oncometabolite d-2HG alters T cell metabolism to impair CD8(+) T cell function.

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Generation and characterization of human U-2 OS cell lines with the CRISPR/Cas9-edited protoporphyrinogen oxidase IX gene.

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FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics.

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Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway.

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Metabolic targeting of cancer by a ubiquinone uncompetitive inhibitor of mitochondrial complex I.

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Cell chemical biology 2022 Mar 17;29(3):436-450.e15

LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.

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Development (Cambridge, England) 2022 Mar 15;149(6)

Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4.

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Cellular & molecular biology letters 2022 Feb 2;27(1):11

Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength.

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The Absence of Parkin Does Not Promote Dopamine or Mitochondrial Dysfunction in PolgA(D257A/D257A) Mitochondrial Mutator Mice.

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Punicalagin Protects Against Diabetic Cardiomyopathy by Promoting Opa1-Mediated Mitochondrial Fusion via Regulating PTP1B-Stat3 Pathway.

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Imatinib Regulates miR-483-3p and Mitochondrial Respiratory Complexes in Gastrointestinal Stromal Tumors.

Huang WK, Shi H, Akçakaya P, Zeljic K, Gangaev A, Caramuta S, Yeh CN, Bränström R, Larsson C, Lui WO
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Nature 2021 Oct;598(7880):364-367

Single-cell analysis reveals androgen receptor regulates the ER-to-Golgi trafficking pathway with CREB3L2 to drive prostate cancer progression.

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AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.

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Nature cell biology 2021 Mar;23(3):268-277

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Wu Z, Zuo M, Zeng L, Cui K, Liu B, Yan C, Chen L, Dong J, Shangguan F, Hu W, He H, Lu B, Song Z
EMBO reports 2021 Jan 7;22(1):e50827

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Molecular nutrition & food research 2021 Aug;65(15):e2001202

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Mitochondria in Embryogenesis: An Organellogenesis Perspective.

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Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation.

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Cell metabolism 2019 Dec 3;30(6):1120-1130.e5

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Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity.

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Glutathione Reduction of Patulin-Evoked Cytotoxicity in HEK293 Cells by the Prevention of Oxidative Damage and the Mitochondrial Apoptotic Pathway.

Wang X, Jin C, Zhong Y, Li X, Han J, Xue W, Wu P, Xia X, Peng X
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CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.

Han Y, Sun S, Zhao M, Zhang Z, Gong S, Gao P, Liu J, Zhou J, Ma D, Gao Q, Wu P
Disease markers 2016;2016:3528064

Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization.

Yang W, Nagasawa K, Münch C, Xu Y, Satterstrom K, Jeong S, Hayes SD, Jedrychowski MP, Vyas FS, Zaganjor E, Guarani V, Ringel AE, Gygi SP, Harper JW, Haigis MC
Cell 2016 Nov 3;167(4):985-1000.e21

Mechanism of super-assembly of respiratory complexes III and IV.

Cogliati S, Calvo E, Loureiro M, Guaras AM, Nieto-Arellano R, Garcia-Poyatos C, Ezkurdia I, Mercader N, Vázquez J, Enriquez JA
Nature 2016 Nov 24;539(7630):579-582

COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.

Martinez Lyons A, Ardissone A, Reyes A, Robinson AJ, Moroni I, Ghezzi D, Fernandez-Vizarra E, Zeviani M
Journal of medical genetics 2016 Dec;53(12):846-849

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse brain tissue were subjected to SDS PAGE followed by western blot with 14742-1-AP(UQCRC2 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using UQCRC2 antibody 14742-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon cancer using 14742-1-AP(UQCRC2 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon cancer using 14742-1-AP(UQCRC2 antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue