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Learn12604-1-AP
antibody from Proteintech Group
Targeting: IFIT2
cig42, G10P2, GARG-39, IFI-54, IFI54, ISG-54K
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [27]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- 12604-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- IFIT2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IFIT2 antibody (Cat. #12604-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The Landscape of the Tumor Microenvironment in Skin Cutaneous Melanoma Reveals a Prognostic and Immunotherapeutically Relevant Gene Signature.
Super-enhancer-associated long noncoding RNA RP11-569A11.1 inhibited cell progression and metastasis by regulating IFIT2 in colorectal cancer.
PML-II regulates ERK and AKT signal activation and IFNα-induced cell death.
ETV7 limits antiviral gene expression and control of influenza viruses.
Translation stress and collided ribosomes are co-activators of cGAS.
Human IFIT3 Protein Induces Interferon Signaling and Inhibits Adenovirus Immediate Early Gene Expression.
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity.
Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis.
The Small t Antigen of JC Virus Antagonizes RIG-I-Mediated Innate Immunity by Inhibiting TRIM25's RNA Binding Ability.
Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses.
ISG15-dependent Activation of the RNA Sensor MDA5 and its Antagonism by the SARS-CoV-2 papain-like protease.
Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs.
Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.
Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cells.
The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.
Ribosome biogenesis restricts innate immune responses to virus infection and DNA.
Anti-apoptotic effect by the suppression of IRF1 as a downstream of Wnt/β-catenin signaling in colorectal cancer cells.
Temporal Proteomic Analysis of BK Polyomavirus Infection Reveals Virus-Induced G2 Arrest and Highly Effective Evasion of Innate Immune Sensing.
The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling.
IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA.
Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.
PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2.
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
Decreased expression of interferon-induced protein 2 (IFIT2) by Wnt/β-catenin signaling confers anti-apoptotic properties to colorectal cancer cells.
Long non-coding RNA LINC00161 sensitises osteosarcoma cells to cisplatin-induced apoptosis by regulating the miR-645-IFIT2 axis.
A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity.
Herpes Simplex Virus 1 Tegument Protein UL41 Counteracts IFIT3 Antiviral Innate Immunity.
Zhou S, Sun Y, Chen T, Wang J, He J, Lyu J, Shen Y, Chen X, Yang R
Frontiers in cell and developmental biology 2021;9:739594
Frontiers in cell and developmental biology 2021;9:739594
Super-enhancer-associated long noncoding RNA RP11-569A11.1 inhibited cell progression and metastasis by regulating IFIT2 in colorectal cancer.
Chen H, Zheng J, Yan L, Zhou X, Jiang P, Yan F
Journal of clinical laboratory analysis 2021 Jun;35(6):e23780
Journal of clinical laboratory analysis 2021 Jun;35(6):e23780
PML-II regulates ERK and AKT signal activation and IFNα-induced cell death.
Meng X, Chen Y, Macip S, Leppard K
Cell communication and signaling : CCS 2021 Jul 2;19(1):70
Cell communication and signaling : CCS 2021 Jul 2;19(1):70
ETV7 limits antiviral gene expression and control of influenza viruses.
Froggatt HM, Harding AT, Chaparian RR, Heaton NS
Science signaling 2021 Jul 13;14(691)
Science signaling 2021 Jul 13;14(691)
Translation stress and collided ribosomes are co-activators of cGAS.
Wan L, Juszkiewicz S, Blears D, Bajpe PK, Han Z, Faull P, Mitter R, Stewart A, Snijders AP, Hegde RS, Svejstrup JQ
Molecular cell 2021 Jul 1;81(13):2808-2822.e10
Molecular cell 2021 Jul 1;81(13):2808-2822.e10
Human IFIT3 Protein Induces Interferon Signaling and Inhibits Adenovirus Immediate Early Gene Expression.
Chikhalya A, Dittmann M, Zheng Y, Sohn SY, Rice CM, Hearing P
mBio 2021 Dec 21;12(6):e0282921
mBio 2021 Dec 21;12(6):e0282921
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity.
Liu G, Lee JH, Parker ZM, Acharya D, Chiang JJ, van Gent M, Riedl W, Davis-Gardner ME, Wies E, Chiang C, Gack MU
Nature microbiology 2021 Apr;6(4):467-478
Nature microbiology 2021 Apr;6(4):467-478
Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis.
Torres-Odio S, Lei Y, Gispert S, Maletzko A, Key J, Menissy SS, Wittig I, Auburger G, West AP
Journal of immunology (Baltimore, Md. : 1950) 2021 Apr 15;206(8):1890-1900
Journal of immunology (Baltimore, Md. : 1950) 2021 Apr 15;206(8):1890-1900
The Small t Antigen of JC Virus Antagonizes RIG-I-Mediated Innate Immunity by Inhibiting TRIM25's RNA Binding Ability.
Chiang C, Dvorkin S, Chiang JJ, Potter RB, Gack MU
mBio 2021 Apr 13;12(2)
mBio 2021 Apr 13;12(2)
Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses.
Chen J, Harding SM, Natesan R, Tian L, Benci JL, Li W, Minn AJ, Asangani IA, Greenberg RA
Cell reports 2020 Sep 1;32(9):108080
Cell reports 2020 Sep 1;32(9):108080
ISG15-dependent Activation of the RNA Sensor MDA5 and its Antagonism by the SARS-CoV-2 papain-like protease.
Liu G, Lee JH, Parker ZM, Acharya D, Chiang JJ, van Gent M, Riedl W, Davis-Gardner ME, Wies E, Chiang C, Gack MU
bioRxiv : the preprint server for biology 2020 Oct 27;
bioRxiv : the preprint server for biology 2020 Oct 27;
Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs.
Tran V, Ledwith MP, Thamamongood T, Higgins CA, Tripathi S, Chang MW, Benner C, García-Sastre A, Schwemmle M, Boon ACM, Diamond MS, Mehle A
Nature microbiology 2020 Dec;5(12):1490-1503
Nature microbiology 2020 Dec;5(12):1490-1503
Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.
Mears HV, Sweeney TR
The Journal of biological chemistry 2020 Dec 18;295(51):17781-17801
The Journal of biological chemistry 2020 Dec 18;295(51):17781-17801
Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cells.
Mears HV, Emmott E, Chaudhry Y, Hosmillo M, Goodfellow IG, Sweeney TR
Wellcome open research 2019;4:82
Wellcome open research 2019;4:82
The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.
McFarlane S, Orr A, Roberts APE, Conn KL, Iliev V, Loney C, da Silva Filipe A, Smollett K, Gu Q, Robertson N, Adams PD, Rai TS, Boutell C
PLoS pathogens 2019 Mar;15(3):e1007667
PLoS pathogens 2019 Mar;15(3):e1007667
Ribosome biogenesis restricts innate immune responses to virus infection and DNA.
Bianco C, Mohr I
eLife 2019 Dec 16;8
eLife 2019 Dec 16;8
Anti-apoptotic effect by the suppression of IRF1 as a downstream of Wnt/β-catenin signaling in colorectal cancer cells.
Ohsugi T, Yamaguchi K, Zhu C, Ikenoue T, Takane K, Shinozaki M, Tsurita G, Yano H, Furukawa Y
Oncogene 2019 Aug;38(32):6051-6064
Oncogene 2019 Aug;38(32):6051-6064
Temporal Proteomic Analysis of BK Polyomavirus Infection Reveals Virus-Induced G2 Arrest and Highly Effective Evasion of Innate Immune Sensing.
Caller LG, Davies CTR, Antrobus R, Lehner PJ, Weekes MP, Crump CM
Journal of virology 2019 Aug 15;93(16)
Journal of virology 2019 Aug 15;93(16)
The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling.
Chiang C, Pauli EK, Biryukov J, Feister KF, Meng M, White EA, Münger K, Howley PM, Meyers C, Gack MU
Journal of virology 2018 Mar 15;92(6)
Journal of virology 2018 Mar 15;92(6)
IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA.
Fleith RC, Mears HV, Leong XY, Sanford TJ, Emmott E, Graham SC, Mansur DS, Sweeney TR
Nucleic acids research 2018 Jun 1;46(10):5269-5285
Nucleic acids research 2018 Jun 1;46(10):5269-5285
Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.
Alandijany T, Roberts APE, Conn KL, Loney C, McFarlane S, Orr A, Boutell C
PLoS pathogens 2018 Jan;14(1):e1006769
PLoS pathogens 2018 Jan;14(1):e1006769
PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2.
Shen H, Zhan M, Zhang Y, Huang S, Xu S, Huang X, He M, Yao Y, Man M, Wang J
Cell death & disease 2018 Jan 22;9(2):71
Cell death & disease 2018 Jan 22;9(2):71
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
Burgess HM, Mohr I
Journal of virology 2018 Aug 1;92(15)
Journal of virology 2018 Aug 1;92(15)
Decreased expression of interferon-induced protein 2 (IFIT2) by Wnt/β-catenin signaling confers anti-apoptotic properties to colorectal cancer cells.
Ohsugi T, Yamaguchi K, Zhu C, Ikenoue T, Furukawa Y
Oncotarget 2017 Nov 21;8(59):100176-100186
Oncotarget 2017 Nov 21;8(59):100176-100186
Long non-coding RNA LINC00161 sensitises osteosarcoma cells to cisplatin-induced apoptosis by regulating the miR-645-IFIT2 axis.
Wang Y, Zhang L, Zheng X, Zhong W, Tian X, Yin B, Tian K, Zhang W
Cancer letters 2016 Nov 28;382(2):137-146
Cancer letters 2016 Nov 28;382(2):137-146
A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity.
Chan YK, Gack MU
Nature immunology 2016 May;17(5):523-30
Nature immunology 2016 May;17(5):523-30
Herpes Simplex Virus 1 Tegument Protein UL41 Counteracts IFIT3 Antiviral Innate Immunity.
Jiang Z, Su C, Zheng C
Journal of virology 2016 Dec 15;90(24):11056-11061
Journal of virology 2016 Dec 15;90(24):11056-11061
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A431 cells were subjected to SDS PAGE followed by western blot with 12604-1-AP( IFIT2 Antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IFIT2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IFIT2. This antibody recognizes human, mouse antigen. The IFIT2 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
