Antibody data
- Antibody Data
- Antigen structure
- References [30]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 12323-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12323-1-AP, RRID:AB_2159695
- Product name
- PAX6 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PAX6 antibody (Cat. #12323-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Human neuropathology confirms projection neuron and interneuron defects and delayed oligodendrocyte production and maturation in FOXG1 syndrome.
Immunohistochemical evidence for adult human neurogenesis in health and disease.
Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells.
Perinatal exposure to nonylphenol promotes proliferation of granule cell precursors in offspring cerebellum: Involvement of the activation of Notch2 signaling.
PAX6 contributes to the activation and proliferation of hepatic stellate cells via activating Hedgehog/GLI1 pathway.
Δ9-tetrahydrocannabinol and 2-AG decreases neurite outgrowth and differentially affects ERK1/2 and Akt signaling in hiPSC-derived cortical neurons.
Computational and functional analyses of T2D GWAS SNPs for transcription factor binding.
Wounding Induces Facultative Opn5-Dependent Circadian Photoreception in the Murine Cornea.
ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling.
Zinc Promotes Patient-Derived Induced Pluripotent Stem Cell Neural Differentiation via ERK-STAT Signaling.
The generation of an induced pluripotent stem cell line (DCGi001-A) from an individual with FOXG1 syndrome carrying the c.460dupG (p.Glu154fs) variation in the FOXG1 gene.
Down-regulation of ATF1 leads to early neuroectoderm differentiation of human embryonic stem cells by increasing the expression level of SOX2.
Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.
Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex.
LIMK1 and LIMK2 regulate cortical development through affecting neural progenitor cell proliferation and migration.
Silver Nanoparticles Compromise Female Embryonic Stem Cell Differentiation through Disturbing X Chromosome Inactivation.
The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance in non-small cell lung cancer through PI3K/AKT signaling.
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Rapid Differentiation of Multi-Zone Ocular Cells from Human Induced Pluripotent Stem Cells and Generation of Corneal Epithelial and Endothelial Cells.
Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer's Disease Adults.
Hydrocephalus due to multiple ependymal malformations is caused by mutations in the MPDZ gene.
Dynamic Expression Patterns of Progenitor and Neuron Layer Markers in the Developing Human Dentate Gyrus and Fimbria.
miR-342-5p Regulates Neural Stem Cell Proliferation and Differentiation Downstream to Notch Signaling in Mice.
Dynamic Expression Patterns of Progenitor and Pyramidal Neuron Layer Markers in the Developing Human Hippocampus.
Olig2 regulates Purkinje cell generation in the early developing mouse cerebellum.
MicroRNA-mediated non-cell-autonomous regulation of cortical radial glial transformation revealed by a Dicer1 knockout mouse model.
PAK1 regulates cortical development via promoting neuronal migration and progenitor cell proliferation.
Abnormal cerebellar development and Purkinje cell defects in Lgl1-Pax2 conditional knockout mice.
A robust method to derive functional neural crest cells from human pluripotent stem cells.
Specification and maintenance of oligodendrocyte precursor cells from neural progenitor cells: involvement of microRNA-7a.
Wilpert NM, Marguet F, Maillard C, Guimiot F, Martinovic J, Drunat S, Attié-Bitach T, Razavi F, Tessier A, Capri Y, Laquerrière A, Bahi-Buisson N
European journal of medical genetics 2021 Sep;64(9):104282
European journal of medical genetics 2021 Sep;64(9):104282
Immunohistochemical evidence for adult human neurogenesis in health and disease.
Gault N, Szele FG
WIREs mechanisms of disease 2021 Nov;13(6):e1526
WIREs mechanisms of disease 2021 Nov;13(6):e1526
Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells.
Guo X, Cui C, Song J, He Q, Zang N, Hu H, Wang X, Li D, Wang C, Hou X, Li X, Liang K, Yan F, Chen L
Molecular and cellular endocrinology 2021 Nov 1;537:111425
Molecular and cellular endocrinology 2021 Nov 1;537:111425
Perinatal exposure to nonylphenol promotes proliferation of granule cell precursors in offspring cerebellum: Involvement of the activation of Notch2 signaling.
Fang Y, Che X, You M, Xu Y, Wang Y
Neurochemistry international 2020 Nov;140:104843
Neurochemistry international 2020 Nov;140:104843
PAX6 contributes to the activation and proliferation of hepatic stellate cells via activating Hedgehog/GLI1 pathway.
Li C, Tan YH, Sun J, Deng FM, Liu YL
Biochemical and biophysical research communications 2020 May 28;526(2):314-320
Biochemical and biophysical research communications 2020 May 28;526(2):314-320
Δ9-tetrahydrocannabinol and 2-AG decreases neurite outgrowth and differentially affects ERK1/2 and Akt signaling in hiPSC-derived cortical neurons.
Shum C, Dutan L, Annuario E, Warre-Cornish K, Taylor SE, Taylor RD, Andreae LC, Buckley NJ, Price J, Bhattacharyya S, Srivastava DP
Molecular and cellular neurosciences 2020 Mar;103:103463
Molecular and cellular neurosciences 2020 Mar;103:103463
Computational and functional analyses of T2D GWAS SNPs for transcription factor binding.
Cheng M, Huang X, Zhang M, Huang Q
Biochemical and biophysical research communications 2020 Mar 12;523(3):658-665
Biochemical and biophysical research communications 2020 Mar 12;523(3):658-665
Wounding Induces Facultative Opn5-Dependent Circadian Photoreception in the Murine Cornea.
Díaz NM, Lang RA, Van Gelder RN, Buhr ED
Investigative ophthalmology & visual science 2020 Jun 3;61(6):37
Investigative ophthalmology & visual science 2020 Jun 3;61(6):37
ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling.
Sun X, Peng X, Cao Y, Zhou Y, Sun Y
Nature communications 2020 Jun 12;11(1):2984
Nature communications 2020 Jun 12;11(1):2984
Zinc Promotes Patient-Derived Induced Pluripotent Stem Cell Neural Differentiation via ERK-STAT Signaling.
Yang M, Bao D, Shi A, Yuan H, Wang J, He W, Tong X, Qin H
Stem cells and development 2020 Jul 1;29(13):863-875
Stem cells and development 2020 Jul 1;29(13):863-875
The generation of an induced pluripotent stem cell line (DCGi001-A) from an individual with FOXG1 syndrome carrying the c.460dupG (p.Glu154fs) variation in the FOXG1 gene.
Waite AJ, Millar D, Clarke A
Stem cell research 2020 Dec;49:102018
Stem cell research 2020 Dec;49:102018
Down-regulation of ATF1 leads to early neuroectoderm differentiation of human embryonic stem cells by increasing the expression level of SOX2.
Yang SC, Liu JJ, Wang CK, Lin YT, Tsai SY, Chen WJ, Huang WK, Tu PA, Lin YC, Chang CF, Cheng CL, Lin H, Lai CY, Lin CY, Lee YH, Chiu YC, Hsu CC, Hsu SC, Hsiao M, Schuyler SC, Lu FL, Lu J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10577-10592
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10577-10592
Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.
Huang M, Tailor J, Zhen Q, Gillmor AH, Miller ML, Weishaupt H, Chen J, Zheng T, Nash EK, McHenry LK, An Z, Ye F, Takashima Y, Clarke J, Ayetey H, Cavalli FMG, Luu B, Moriarity BS, Ilkhanizadeh S, Chavez L, Yu C, Kurian KM, Magnaldo T, Sevenet N, Koch P, Pollard SM, Dirks P, Snyder MP, Largaespada DA, Cho YJ, Phillips JJ, Swartling FJ, Morrissy AS, Kool M, Pfister SM, Taylor MD, Smith A, Weiss WA
Cell stem cell 2019 Sep 5;25(3):433-446.e7
Cell stem cell 2019 Sep 5;25(3):433-446.e7
Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex.
Arai Y, Cwetsch AW, Coppola E, Cipriani S, Nishihara H, Kanki H, Saillour Y, Freret-Hodara B, Dutriaux A, Okada N, Okano H, Dehay C, Nardelli J, Gressens P, Shimogori T, D'Onofrio G, Pierani A
Cell reports 2019 Oct 15;29(3):645-658.e5
Cell reports 2019 Oct 15;29(3):645-658.e5
LIMK1 and LIMK2 regulate cortical development through affecting neural progenitor cell proliferation and migration.
Mao R, Deng R, Wei Y, Han L, Meng Y, Xie W, Jia Z
Molecular brain 2019 Jul 18;12(1):67
Molecular brain 2019 Jul 18;12(1):67
Silver Nanoparticles Compromise Female Embryonic Stem Cell Differentiation through Disturbing X Chromosome Inactivation.
Zhang J, Chen Y, Gao M, Wang Z, Liu R, Xia T, Liu S
ACS nano 2019 Feb 26;13(2):2050-2061
ACS nano 2019 Feb 26;13(2):2050-2061
The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance in non-small cell lung cancer through PI3K/AKT signaling.
Wu DM, Zhang T, Liu YB, Deng SH, Han R, Liu T, Li J, Xu Y
Cell death & disease 2019 Apr 25;10(5):349
Cell death & disease 2019 Apr 25;10(5):349
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Zhong X, Cui P, Cai Y, Wang L, He X, Long P, Lu K, Yan R, Zhang Y, Pan X, Zhao X, Li W, Zhang H, Zhou Q, Gao P
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Rapid Differentiation of Multi-Zone Ocular Cells from Human Induced Pluripotent Stem Cells and Generation of Corneal Epithelial and Endothelial Cells.
Li Z, Duan H, Li W, Hu X, Jia Y, Zhao C, Zhang S, Zhou Q, Shi W
Stem cells and development 2019 Apr 1;28(7):454-463
Stem cells and development 2019 Apr 1;28(7):454-463
Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer's Disease Adults.
Cipriani S, Ferrer I, Aronica E, Kovacs GG, Verney C, Nardelli J, Khung S, Delezoide AL, Milenkovic I, Rasika S, Manivet P, Benifla JL, Deriot N, Gressens P, Adle-Biassette H
Cerebral cortex (New York, N.Y. : 1991) 2018 Jul 1;28(7):2458-2478
Cerebral cortex (New York, N.Y. : 1991) 2018 Jul 1;28(7):2458-2478
Hydrocephalus due to multiple ependymal malformations is caused by mutations in the MPDZ gene.
Saugier-Veber P, Marguet F, Lecoquierre F, Adle-Biassette H, Guimiot F, Cipriani S, Patrier S, Brasseur-Daudruy M, Goldenberg A, Layet V, Capri Y, Gérard M, Frébourg T, Laquerrière A
Acta neuropathologica communications 2017 May 1;5(1):36
Acta neuropathologica communications 2017 May 1;5(1):36
Dynamic Expression Patterns of Progenitor and Neuron Layer Markers in the Developing Human Dentate Gyrus and Fimbria.
Cipriani S, Journiac N, Nardelli J, Verney C, Delezoide AL, Guimiot F, Gressens P, Adle-Biassette H
Cerebral cortex (New York, N.Y. : 1991) 2017 Jan 1;27(1):358-372
Cerebral cortex (New York, N.Y. : 1991) 2017 Jan 1;27(1):358-372
miR-342-5p Regulates Neural Stem Cell Proliferation and Differentiation Downstream to Notch Signaling in Mice.
Gao F, Zhang YF, Zhang ZP, Fu LA, Cao XL, Zhang YZ, Guo CJ, Yan XC, Yang QC, Hu YY, Zhao XH, Wang YZ, Wu SX, Ju G, Zheng MH, Han H
Stem cell reports 2017 Apr 11;8(4):1032-1045
Stem cell reports 2017 Apr 11;8(4):1032-1045
Dynamic Expression Patterns of Progenitor and Pyramidal Neuron Layer Markers in the Developing Human Hippocampus.
Cipriani S, Nardelli J, Verney C, Delezoide AL, Guimiot F, Gressens P, Adle-Biassette H
Cerebral cortex (New York, N.Y. : 1991) 2016 Mar;26(3):1255-71
Cerebral cortex (New York, N.Y. : 1991) 2016 Mar;26(3):1255-71
Olig2 regulates Purkinje cell generation in the early developing mouse cerebellum.
Ju J, Liu Q, Zhang Y, Liu Y, Jiang M, Zhang L, He X, Peng C, Zheng T, Lu QR, Li H
Scientific reports 2016 Jul 29;6:30711
Scientific reports 2016 Jul 29;6:30711
MicroRNA-mediated non-cell-autonomous regulation of cortical radial glial transformation revealed by a Dicer1 knockout mouse model.
Zhang C, Ge X, Liu Q, Jiang M, Li MW, Li H
Glia 2015 May;63(5):860-76
Glia 2015 May;63(5):860-76
PAK1 regulates cortical development via promoting neuronal migration and progenitor cell proliferation.
Pan X, Chang X, Leung C, Zhou Z, Cao F, Xie W, Jia Z
Molecular brain 2015 Jun 5;8:36
Molecular brain 2015 Jun 5;8:36
Abnormal cerebellar development and Purkinje cell defects in Lgl1-Pax2 conditional knockout mice.
Hou C, Ding L, Zhang J, Jin Y, Sun C, Li Z, Sun X, Zhang T, Zhang A, Li H, Gao J
Developmental biology 2014 Nov 1;395(1):167-81
Developmental biology 2014 Nov 1;395(1):167-81
A robust method to derive functional neural crest cells from human pluripotent stem cells.
Kreitzer FR, Salomonis N, Sheehan A, Huang M, Park JS, Spindler MJ, Lizarraga P, Weiss WA, So PL, Conklin BR
American journal of stem cells 2013;2(2):119-31
American journal of stem cells 2013;2(2):119-31
Specification and maintenance of oligodendrocyte precursor cells from neural progenitor cells: involvement of microRNA-7a.
Zhao X, Wu J, Zheng M, Gao F, Ju G
Molecular biology of the cell 2012 Aug;23(15):2867-78
Molecular biology of the cell 2012 Aug;23(15):2867-78
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human stomach tissue were subjected to SDS PAGE followed by western blot with 12323-1-AP(PAX6 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 12323-1-AP(PAX6 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PAX6 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PAX6. This antibody recognizes human, mouse, rat antigen. The PAX6 antibody has been validated for the following applications: ELISA, WB, IHC analysis.