Antibody data
- Antibody Data
- Antigen structure
- References [174]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 11312-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11312-1-AP, RRID:AB_2127004
- Product name
- IRF3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IRF3 antibody (Cat. #11312-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice.
A novel host restriction factor MRPS6 mediates the inhibition of PDCoV infection in HIEC-6 cells.
TRIM25 predominately associates with anti-viral stress granules.
Salvianolic acid A prevents UV-induced skin damage by inhibiting the cGAS-STING pathway.
Manganese suppresses the development of oral leukoplakia by activating the immune response.
The combination of Schisandrin C and Luteolin synergistically attenuates hepatitis B virus infection via repressing HBV replication and promoting cGAS-STING pathway activation in macrophages.
Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication.
Identification of key mitochondria-related genes and their relevance to the immune system linking Parkinson's disease and primary Sjögren's syndrome through integrated bioinformatics analyses.
Flavonoid extracted from Epimedium attenuate cGAS-STING-mediated diseases by targeting the formation of functional STING signalosome.
Compound Danshen Dripping Pill effectively alleviates cGAS-STING-triggered diseases by disrupting STING-TBK1 interaction.
Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling Pathway.
Microtubule disruption synergizes with STING signaling to show potent and broad-spectrum antiviral activity.
PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages.
STING deficiency alleviates ferroptosis through FPN1 stabilization in diabetic kidney disease.
mtDNA regulates cGAS-STING signaling pathway in adenomyosis.
Therapeutic efficacy of a novel self-assembled immunostimulatory siRNA combining apoptosis promotion with RIG-I activation in gliomas.
IFNα-induced BST2(+) tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling.
A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice.
Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A.
Japanese encephalitis virus NS4B inhibits interferon beta production by targeting TLR3 and TRIF.
Porcine reproductive and respiratory syndrome virus-mediated lactate facilitates virus replication by targeting MAVS.
Role of OGDH in Atophagy-IRF3-IFN-β pathway during classical swine fever virus infection.
4-Octyl itaconate restricts STING activation by blocking its palmitoylation.
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation.
The D129L protein of African swine fever virus interferes with the binding of transcriptional coactivator p300 and IRF3 to prevent beta interferon induction.
Naringenin Improves Innate Immune Suppression after PRRSV Infection by Reactivating the RIG-I-MAVS Signaling Pathway, Promoting the Production of IFN-I.
Systemic administration of STING agonist promotes myeloid cells maturation and antitumor immunity through regulating hematopoietic stem and progenitor cell fate.
A Dihydroartemisinin-Loaded Nanoreactor Motivates Anti-Cancer Immunotherapy by Synergy-Induced Ferroptosis to Activate Cgas/STING for Reprogramming of Macrophage.
GSTM2 alleviates heart failure by inhibiting DNA damage in cardiomyocytes.
Porcine promyelocytic leukemia protein isoforms suppress Japanese encephalitis virus replication in PK15 cells.
cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis.
Flavonoids derived from licorice suppress LPS-induced acute lung injury in mice by inhibiting the cGAS-STING signaling pathway.
STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion.
Japanese encephalitis virus induces apoptosis by activating the RIG-1 signaling pathway.
MGF360-12L of ASFV-SY18 is an immune-evasion protein that inhibits host type I IFN, NF-κB, and JAK/STAT pathways.
IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway.
Prediction and Verification of Curcumin as a Potential Drug for Inhibition of PDCoV Replication in LLC-PK1 Cells.
SARS-CoV-2 NSP13 interacts with host IRF3, blocking antiviral immune responses.
TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection.
Transcriptome Profiling of Vero E6 Cells during Original Parental or Cell-Attenuated Porcine Epidemic Diarrhea Virus Infection.
SMYD2 inhibition-mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity.
Epstein-Barr Virus Envelope Glycoprotein gp110 Inhibits IKKi-Mediated Activation of NF-κB and Promotes the Degradation of β-Catenin.
LncRNA ZNF593-AS alleviates diabetic cardiomyopathy via suppressing IRF3 signaling pathway.
Yi-Shen-Xie-Zhuo formula alleviates cisplatin-induced AKI by regulating inflammation and apoptosis via the cGAS/STING pathway.
STING deficiency protects against wasp venom-induced acute kidney injury.
An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation.
STAT3 regulates antiviral immunity by suppressing excessive interferon signaling.
Schisandrin C enhances cGAS-STING pathway activation and inhibits HBV replication.
mascRNA alleviates STING-TBK1 signaling-mediated immune response through promoting ubiquitination of STING.
Sirt1 Negatively Regulates Cellular Antiviral Responses by Preventing the Cytoplasmic Translocation of Interferon-Inducible Protein 16 in Human Cells.
Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy.
African swine fever virus S273R protein antagonizes type I interferon production by interfering with TBK1 and IRF3 interaction.
TBK1-stabilized ZNF268a recruits SETD4 to methylate TBK1 for efficient interferon signaling.
NSUN2-mediated M(5)c methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections.
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production.
RNF144A promotes antiviral responses by modulating STING ubiquitination.
FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-β Expression through Regulating IRF-3.
Metformin promotes cGAS/STING signaling pathway activation by blocking AKT phosphorylation in gastric cancer.
A transformable nanoplatform with multiple therapeutic and immunostimulatory properties for treatment of advanced cancers.
Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy.
A HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway.
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice.
STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages.
WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response.
A role of STING signaling in obesity-induced lung inflammation.
DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma.
The Papain-Like Protease of Porcine Reproductive and Respiratory Syndrome Virus Impedes STING Translocation from the Endoplasmic Reticulum to the Golgi Apparatus by Deubiquitinating STIM1.
Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor.
Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis.
Predicting the Immune Microenvironment and Prognosis with a NETosis-Related lncRNA Signature in Head and Neck Squamous Cell Carcinoma.
Resveratrol reduces inflammatory response and detrimental effects in chronic cerebral hypoperfusion by down-regulating stimulator of interferon genes/TANK-binding kinase 1/interferon regulatory factor 3 signaling.
Mechanism of selenomethionine inhibiting of PDCoV replication in LLC-PK1 cells based on STAT3/miR-125b-5p-1/HK2 signaling.
DDX56 inhibits PRV replication through regulation of IFN-β signaling pathway by targeting cGAS.
Antiviral Effect of Selenomethionine on Porcine Deltacoronavirus in Pig Kidney Epithelial Cells.
Transcriptome Analyses of Senecavirus A-Infected PK-15 Cells: RIG-I and IRF7 Are the Important Factors in Inducing Type III Interferons.
Severe Acute Respiratory Syndrome Coronavirus 2 ORF8 Protein Inhibits Type I Interferon Production by Targeting HSP90B1 Signaling.
Porcine Sapelovirus 3C(pro) Inhibits the Production of Type I Interferon.
Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases.
Phosphorylation of Ser82 on IRF3 acts as negative-feedback regulation of IRF3-dependent innate immunity.
NBR1 mediates autophagic degradation of IRF3 to negatively regulate type I interferon production.
The A137R Protein of African Swine Fever Virus Inhibits Type I Interferon Production via the Autophagy-Mediated Lysosomal Degradation of TBK1.
RUNX1 inhibits the antiviral immune response against influenza A virus through attenuating type I interferon signaling.
Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b.
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus.
I226R Protein of African Swine Fever Virus Is a Suppressor of Innate Antiviral Responses.
HAO1-mediated oxalate metabolism promotes lung pre-metastatic niche formation by inducing neutrophil extracellular traps.
TRIM25 inhibits influenza A virus infection, destabilizes viral mRNA, but is redundant for activating the RIG-I pathway.
Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics.
IKKε protects against starvation-induced NLRP3 inflammasome and pyroptosis in H9c2 cells by alleviating mitochondrial injury.
Targeting KDM4C enhances CD8(+) T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer.
Induction of HOXA3 by Porcine Reproductive and Respiratory Syndrome Virus Inhibits Type I Interferon Response through Negative Regulation of HO-1 Transcription.
An alternatively spliced STING isoform localizes in the cytoplasmic membrane and directly senses extracellular cGAMP.
Multifaceted Effects and Mechanisms of N-Acetylcysteine on Intestinal Injury in a Porcine Epidemic Diarrhea Virus-Infected Porcine Model.
Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity.
HSP27 Attenuates cGAS-Mediated IFN-β Signaling through Ubiquitination of cGAS and Promotes PRV Infection.
EZH2 Inhibitor Enhances the STING Agonist‒Induced Antitumor Immunity in Melanoma.
Herpes simplex virus protein UL56 inhibits cGAS-Mediated DNA sensing to evade antiviral immunity.
Heat Shock-Binding Protein 21 Regulates the Innate Immune Response to Viral Infection.
SARS-CoV-2 spike protein-induced cell fusion activates the cGAS-STING pathway and the interferon response.
HSP27 Protein Dampens Encephalomyocarditis Virus Replication by Stabilizing Melanoma Differentiation-Associated Gene 5.
Pseudorabies Virus US3 Protein Inhibits IFN-β Production by Interacting With IRF3 to Block Its Activation.
PARP inhibitor niraparib as a radiosensitizer promotes antitumor immunity of radiotherapy in EGFR-mutated non-small cell lung cancer.
A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response.
Degradation of WTAP blocks antiviral responses by reducing the m(6) A levels of IRF3 and IFNAR1 mRNA.
Inhibition of Antiviral Innate Immunity by Avibirnavirus VP3 via Blocking TBK1-TRAF3 Complex Formation and IRF3 Activation.
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response.
Staphylococcus aureus Induces IFN-β Production via a CARMA3-Independent Mechanism.
Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation.
Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.
Caspase-1 inhibits IFN-β production via cleavage of cGAS during M. bovis infection.
SPOP negatively regulates Toll-like receptor-induced inflammation by disrupting MyD88 self-association.
Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.
Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA.
Pseudorabies virus glycoprotein gE suppresses interferon-β production via CREB-binding protein degradation.
Encephalomyocarditis Virus Abrogates the Interferon Beta Signaling Pathway via Its Structural Protein VP2.
Yiguanjian decoction inhibits macrophage M1 polarization and attenuates hepatic fibrosis induced by CCl(4)/2-AAF.
African swine fever virus MGF505-11R inhibits type I interferon production by negatively regulating the cGAS-STING-mediated signaling pathway.
SRP54 Negatively Regulates IFN-Beta Production and Antiviral Response by Targeting RIG-I and MDA5.
Epstein-Barr Virus Early Protein BFRF1 Suppresses IFN-β Activity by Inhibiting the Activation of IRF3.
Nuclear transporter karyopherin subunit alpha 3 levels modulate Porcine circovirus type 2 replication in PK-15 cells.
PRV UL13 inhibits cGAS-STING-mediated IFN-β production by phosphorylating IRF3.
Essential roles of S100A10 in Toll-like receptor signaling and immunity to infection.
The Nonstructural Protein of Guertu Virus Disrupts Host Defenses by Blocking Antiviral Interferon Induction and Action.
Human Cytomegalovirus Protein UL94 Targets MITA to Evade the Antiviral Immune Response.
Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.
SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production.
The STING-IRF3 pathway is involved in lipotoxic injury of pancreatic β cells in type 2 diabetes.
Silica particles disorganize the polarization of pulmonary macrophages in mice.
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.
Evidence for Sexual Dimorphism in the Response to TLR3 Activation in the Developing Neonatal Mouse Brain: A Pilot Study.
Herpes Simplex Virus Type 2 Immediate Early Protein ICP27 Inhibits IFN-β Production in Mucosal Epithelial Cells by Antagonizing IRF3 Activation.
TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity.
PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing.
A Subcellular Quantitative Proteomic Analysis of Herpes Simplex Virus Type 1-Infected HEK 293T Cells.
ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner.
The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death.
Host HDAC4 regulates the antiviral response by inhibiting the phosphorylation of IRF3.
Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex.
Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death.
NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1.
PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria.
STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation.
USP7-TRIM27 axis negatively modulates antiviral type I IFN signaling.
Inhibition of cGAS-STING-TBK1 signaling pathway by DP96R of ASFV China 2018/1.
MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.
Dampened STING-Dependent Interferon Activation in Bats.
Tick-Borne Encephalitis Virus Nonstructural Protein NS5 Induces RANTES Expression Dependent on the RNA-Dependent RNA Polymerase Activity.
PTEN-L promotes type I interferon responses and antiviral immunity.
Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3.
The Central Role of IFI204 in IFN-β Release and Autophagy Activation during Mycobacterium bovis Infection.
Capsular Polysaccharide is a Main Component of Mycoplasma ovipneumoniae in the Pathogen-Induced Toll-Like Receptor-Mediated Inflammatory Responses in Sheep Airway Epithelial Cells.
West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5.
Porcine 2', 5'-oligoadenylate synthetase 2 inhibits porcine reproductive and respiratory syndrome virus replication in vitro.
Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β.
TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity.
Decreased expression of STING predicts poor prognosis in patients with gastric cancer.
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome.
The tumor suppressor PTEN has a critical role in antiviral innate immunity.
AIM2 inhibits autophagy and IFN-β production during M. bovis infection.
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response.
Attenuation of cerebral ischemic injury in interferon regulatory factor 3-deficient rat.
Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway.
Vinexin-β deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis.
Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA-Binding Activity of IFN Regulatory Factor 3.
HSV-2 immediate-early protein US1 inhibits IFN-β production by suppressing association of IRF-3 with IFN-β promoter.
An alternative splicing isoform of MITA antagonizes MITA-mediated induction of type I IFNs.
Protein phosphatase PP1 negatively regulates the Toll-like receptor- and RIG-I-like receptor-triggered production of type I interferon by inhibiting IRF3 phosphorylation at serines 396 and 385 in macrophage.
HnRNP A1/A2 and SF2/ASF regulate alternative splicing of interferon regulatory factor-3 and affect immunomodulatory functions in human non-small cell lung cancer cells.
Human bocavirus VP2 upregulates IFN-β pathway by inhibiting ring finger protein 125-mediated ubiquitination of retinoic acid-inducible gene-I.
Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities.
Human bocavirus NP1 inhibits IFN-β production by blocking association of IFN regulatory factor 3 with IFNB promoter.
Varicella-zoster virus immediate-early protein ORF61 abrogates the IRF3-mediated innate immune response through degradation of activated IRF3.
Yang NS, Zhong WJ, Sha HX, Zhang CY, Jin L, Duan JX, Xiong JB, You ZJ, Zhou Y, Guan CX
International journal of biological sciences 2024;20(5):1927-1946
International journal of biological sciences 2024;20(5):1927-1946
A novel host restriction factor MRPS6 mediates the inhibition of PDCoV infection in HIEC-6 cells.
Jiang Y, Zhang G, Li L, Chen J, Hao P, Gao Z, Hao J, Xu Z, Wang M, Li C, Jin N
Frontiers in immunology 2024;15:1381026
Frontiers in immunology 2024;15:1381026
TRIM25 predominately associates with anti-viral stress granules.
Shang Z, Zhang S, Wang J, Zhou L, Zhang X, Billadeau DD, Yang P, Zhang L, Zhou F, Bai P, Jia D
Nature communications 2024 May 15;15(1):4127
Nature communications 2024 May 15;15(1):4127
Salvianolic acid A prevents UV-induced skin damage by inhibiting the cGAS-STING pathway.
Zuo Z, He S, Qiu Y, Guo R, He Y, Jiao C, Xia Y, Liu W, Luan C, Guo W
International immunopharmacology 2024 May 10;132:111971
International immunopharmacology 2024 May 10;132:111971
Manganese suppresses the development of oral leukoplakia by activating the immune response.
Shi Y, Su C, Ding T, Zhao H, Wang Y, Ren Y, Wu L, Zhang Q, Liang J, Sun S, Wang J, Li J, Zeng X
Oral diseases 2024 Mar;30(2):462-476
Oral diseases 2024 Mar;30(2):462-476
The combination of Schisandrin C and Luteolin synergistically attenuates hepatitis B virus infection via repressing HBV replication and promoting cGAS-STING pathway activation in macrophages.
Wu Z, Zhao X, Li R, Wen X, Xiu Y, Long M, Li J, Huang X, Wen J, Dong X, Xu Y, Bai Z, Zhan X, Xiao X
Chinese medicine 2024 Mar 18;19(1):48
Chinese medicine 2024 Mar 18;19(1):48
Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication.
Li XQ, Cai MP, Wang MY, Shi BW, Yang GY, Wang J, Chu BB, Ming SL
Virologica Sinica 2024 Jun;39(3):403-413
Virologica Sinica 2024 Jun;39(3):403-413
Identification of key mitochondria-related genes and their relevance to the immune system linking Parkinson's disease and primary Sjögren's syndrome through integrated bioinformatics analyses.
Zong Y, Yang Y, Zhao J, Li L, Luo D, Hu J, Gao Y, Xie X, Shen L, Chen S, Ning L, Jiang L
Computers in biology and medicine 2024 Jun;175:108511
Computers in biology and medicine 2024 Jun;175:108511
Flavonoid extracted from Epimedium attenuate cGAS-STING-mediated diseases by targeting the formation of functional STING signalosome.
Wang Y, Xu G, Wen J, Zhao X, Zhao H, Lv G, Xu Y, Xiu Y, Li J, Chen S, Yao Q, Chen Y, Ma L, Xiao X, Cao J, Bai Z
Immunology 2024 Jun;172(2):295-312
Immunology 2024 Jun;172(2):295-312
Compound Danshen Dripping Pill effectively alleviates cGAS-STING-triggered diseases by disrupting STING-TBK1 interaction.
Shi W, Xu G, Gao Y, Yang H, Liu T, Zhao J, Li H, Wei Z, Hou X, Chen Y, Wen J, Li C, Zhao J, Zhang P, Wang Z, Xiao X, Bai Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155404
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155404
Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling Pathway.
Song Y, Li H, Lian R, Dou X, Li S, Xie J, Li X, Feng R, Li Z
Viruses 2024 Jan 24;16(2)
Viruses 2024 Jan 24;16(2)
Microtubule disruption synergizes with STING signaling to show potent and broad-spectrum antiviral activity.
Han J, Wang Z, Han F, Peng B, Du J, Zhang C
PLoS pathogens 2024 Feb;20(2):e1012048
PLoS pathogens 2024 Feb;20(2):e1012048
PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages.
Peng D, Huang Z, Yang H, Luo Y, Wu Z
Immunity, inflammation and disease 2024 Feb;12(2):e1189
Immunity, inflammation and disease 2024 Feb;12(2):e1189
STING deficiency alleviates ferroptosis through FPN1 stabilization in diabetic kidney disease.
Zhao QX, Yan SB, Wang F, Li XX, Shang GK, Zheng ZJ, Xiao J, Lin ZW, Li CB, Ji XP
Biochemical pharmacology 2024 Apr;222:116102
Biochemical pharmacology 2024 Apr;222:116102
mtDNA regulates cGAS-STING signaling pathway in adenomyosis.
Wang K, Wen Y, Fu X, Wei S, Liu S, Chen M
Free radical biology & medicine 2024 Apr;216:80-88
Free radical biology & medicine 2024 Apr;216:80-88
Therapeutic efficacy of a novel self-assembled immunostimulatory siRNA combining apoptosis promotion with RIG-I activation in gliomas.
Chen J, Liu Z, Fang H, Su Q, Fan Y, Song L, He S
Journal of translational medicine 2024 Apr 29;22(1):395
Journal of translational medicine 2024 Apr 29;22(1):395
IFNα-induced BST2(+) tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling.
Zheng C, Wang J, Zhou Y, Duan Y, Zheng R, Xie Y, Wei X, Wu J, Shen H, Ye M, Kong B, Liu Y, Xu P, Zhang Q, Liang T
Cell reports 2024 Apr 23;43(4):114088
Cell reports 2024 Apr 23;43(4):114088
A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice.
Ma X, Yin J, Qiao L, Wan H, Liu X, Zhou Y, Wu J, Niu L, Wu M, Wang X, Ye H
Molecular cell 2024 Apr 18;84(8):1585-1600.e7
Molecular cell 2024 Apr 18;84(8):1585-1600.e7
Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A.
Huang HX, Zhao CC, Lei XX, Zhang XY, Li YY, Lan T, Zhao BP, Lu JY, Sun WC, Lu HJ, Jin NY
Frontiers in immunology 2023;14:1196031
Frontiers in immunology 2023;14:1196031
Japanese encephalitis virus NS4B inhibits interferon beta production by targeting TLR3 and TRIF.
Zeng Q, Liu J, Li Z, Zhang Y, Zu S, Ding X, Zhang H
Veterinary microbiology 2023 Sep;284:109849
Veterinary microbiology 2023 Sep;284:109849
Porcine reproductive and respiratory syndrome virus-mediated lactate facilitates virus replication by targeting MAVS.
Zhang L, Liu X, Mao J, Sun Y, Gao Y, Bai J, Jiang P
Veterinary microbiology 2023 Sep;284:109846
Veterinary microbiology 2023 Sep;284:109846
Role of OGDH in Atophagy-IRF3-IFN-β pathway during classical swine fever virus infection.
Zeng S, Zhu W, Luo Z, Wu K, Lu Z, Li X, Wang W, Hu W, Qin Y, Chen W, Yi L, Fan S, Chen J
International journal of biological macromolecules 2023 Sep 30;249:126443
International journal of biological macromolecules 2023 Sep 30;249:126443
4-Octyl itaconate restricts STING activation by blocking its palmitoylation.
Su C, Cheng T, Huang J, Zhang T, Yin H
Cell reports 2023 Sep 26;42(9):113040
Cell reports 2023 Sep 26;42(9):113040
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation.
Ouyang W, Wang S, Yan D, Wu J, Zhang Y, Li W, Hu J, Liu Z
Signal transduction and targeted therapy 2023 Sep 21;8(1):371
Signal transduction and targeted therapy 2023 Sep 21;8(1):371
The D129L protein of African swine fever virus interferes with the binding of transcriptional coactivator p300 and IRF3 to prevent beta interferon induction.
Zhang K, Ge H, Zhou P, Li L-F, Dai J, Cao H, Luo Y, Sun Y, Wang Y, Li J, Yu S, Li S, Qiu H-J
Journal of virology 2023 Oct 31;97(10):e0082423
Journal of virology 2023 Oct 31;97(10):e0082423
Naringenin Improves Innate Immune Suppression after PRRSV Infection by Reactivating the RIG-I-MAVS Signaling Pathway, Promoting the Production of IFN-I.
Yu J, Shi H, Song K, Yang Y, Li X, Peng L, Fu B, Yi P
Viruses 2023 Oct 29;15(11)
Viruses 2023 Oct 29;15(11)
Systemic administration of STING agonist promotes myeloid cells maturation and antitumor immunity through regulating hematopoietic stem and progenitor cell fate.
Xu T, Dai J, Tang L, Sun L, Si L, Guo J
Cancer immunology, immunotherapy : CII 2023 Nov;72(11):3491-3505
Cancer immunology, immunotherapy : CII 2023 Nov;72(11):3491-3505
A Dihydroartemisinin-Loaded Nanoreactor Motivates Anti-Cancer Immunotherapy by Synergy-Induced Ferroptosis to Activate Cgas/STING for Reprogramming of Macrophage.
Li LG, Yang XX, Xu HZ, Yu TT, Li QR, Hu J, Peng XC, Han N, Xu X, Chen NN, Chen X, Tang JM, Li TF
Advanced healthcare materials 2023 Nov;12(28):e2301561
Advanced healthcare materials 2023 Nov;12(28):e2301561
GSTM2 alleviates heart failure by inhibiting DNA damage in cardiomyocytes.
Xu H, Wang Z, Wang Y, Pan S, Zhao W, Chen M, Chen X, Tao T, Ma L, Ni Y, Li W
Cell & bioscience 2023 Nov 30;13(1):220
Cell & bioscience 2023 Nov 30;13(1):220
Porcine promyelocytic leukemia protein isoforms suppress Japanese encephalitis virus replication in PK15 cells.
Chen Z, Liu H, Zhu J, Duan X, Wang H, Li X, Zhou X, Zhao A, Yang S
Virology journal 2023 Nov 29;20(1):280
Virology journal 2023 Nov 29;20(1):280
cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis.
Jiang A, Liu J, Wang Y, Zhang C
Free radical biology & medicine 2023 Nov 1;208:516-529
Free radical biology & medicine 2023 Nov 1;208:516-529
Flavonoids derived from licorice suppress LPS-induced acute lung injury in mice by inhibiting the cGAS-STING signaling pathway.
Wen J, Qin S, Li Y, Zhang P, Zhan X, Fang M, Shi C, Mu W, Kan W, Zhao J, Hui S, Hou M, Li H, Xiao X, Xu G, Bai Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113732
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113732
STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion.
Yang M, Jiang H, Ding C, Zhang L, Ding N, Li G, Zhang F, Wang J, Deng L, Liu J, Xu Y
Immunity 2023 May 9;56(5):1013-1026.e6
Immunity 2023 May 9;56(5):1013-1026.e6
Japanese encephalitis virus induces apoptosis by activating the RIG-1 signaling pathway.
Gao M, Liu Z, Guo X, Zhang J, Cheng G, Hu X, Zhang W, Gu C
Archives of virology 2023 May 26;168(6):169
Archives of virology 2023 May 26;168(6):169
MGF360-12L of ASFV-SY18 is an immune-evasion protein that inhibits host type I IFN, NF-κB, and JAK/STAT pathways.
Chen Q, Wang XX, Jiang SW, Gao XT, Huang SY, Liang Y, Jia H, Zhu HF
Polish journal of veterinary sciences 2023 Mar;26(1):119-130
Polish journal of veterinary sciences 2023 Mar;26(1):119-130
IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway.
Chen L, Li X, Deng Y, Bi Y, Yan Z, Yang Y, Zhang X, Li H, Xie J, Feng R
Viruses 2023 Mar 28;15(4)
Viruses 2023 Mar 28;15(4)
Prediction and Verification of Curcumin as a Potential Drug for Inhibition of PDCoV Replication in LLC-PK1 Cells.
Wang X, Wang X, Zhang J, Shan Q, Zhu Y, Xu C, Wang J
International journal of molecular sciences 2023 Mar 20;24(6)
International journal of molecular sciences 2023 Mar 20;24(6)
SARS-CoV-2 NSP13 interacts with host IRF3, blocking antiviral immune responses.
Feng K, Zhang HJ, Min YQ, Zhou M, Deng F, Wang HL, Li PQ, Ning YJ
Journal of medical virology 2023 Jun;95(6):e28881
Journal of medical virology 2023 Jun;95(6):e28881
TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection.
Wang J, Qin X, Huang Y, Zhang Q, Pei J, Wang Y, Goren I, Ma S, Song Z, Liu Y, Xing H, Wang H, Yang B
Autophagy 2023 Jun;19(6):1844-1862
Autophagy 2023 Jun;19(6):1844-1862
Transcriptome Profiling of Vero E6 Cells during Original Parental or Cell-Attenuated Porcine Epidemic Diarrhea Virus Infection.
Peng O, Wu Y, Hu F, Xia Y, Geng R, Huang Y, Zeng S, Hu G, Xue C, Zhang H, Cao Y
Viruses 2023 Jun 23;15(7)
Viruses 2023 Jun 23;15(7)
SMYD2 inhibition-mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity.
Tang M, Chen G, Tu B, Hu Z, Huang Y, DuFort CC, Wan X, Mao Z, Liu Y, Zhu WG, Lu W
Science advances 2023 Jun 16;9(24):eade6624
Science advances 2023 Jun 16;9(24):eade6624
Epstein-Barr Virus Envelope Glycoprotein gp110 Inhibits IKKi-Mediated Activation of NF-κB and Promotes the Degradation of β-Catenin.
Guo Y, Pan L, Wang L, Wang S, Fu J, Luo W, Wang K, Li X, Huang C, Liu Y, Kang H, Zeng Q, Fu X, Huang Z, Li W, He Y, Li L, Peng T, Yang H, Li M, Xiao B, Cai M
Microbiology spectrum 2023 Jun 15;11(3):e0032623
Microbiology spectrum 2023 Jun 15;11(3):e0032623
LncRNA ZNF593-AS alleviates diabetic cardiomyopathy via suppressing IRF3 signaling pathway.
Xie R, Fan J, Wen J, Jin K, Zhan J, Yuan S, Tang Y, Nie X, Wen Z, Li H, Chen C, Wang DW
Molecular therapy. Nucleic acids 2023 Jun 13;32:689-703
Molecular therapy. Nucleic acids 2023 Jun 13;32:689-703
Yi-Shen-Xie-Zhuo formula alleviates cisplatin-induced AKI by regulating inflammation and apoptosis via the cGAS/STING pathway.
Qi J, Luo Q, Zhang Q, Wu M, Zhang L, Qin L, Xue Q, Nie X
Journal of ethnopharmacology 2023 Jun 12;309:116327
Journal of ethnopharmacology 2023 Jun 12;309:116327
STING deficiency protects against wasp venom-induced acute kidney injury.
Lv Y, Lu L, Yu F, Gao Z, Yuan H, Hu F
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1427-1440
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1427-1440
An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation.
Yiu SPT, Zerbe C, Vanderwall D, Huttlin EL, Weekes MP, Gewurz BE
Molecular cell 2023 Jul 6;83(13):2367-2386.e15
Molecular cell 2023 Jul 6;83(13):2367-2386.e15
STAT3 regulates antiviral immunity by suppressing excessive interferon signaling.
Liu S, Liu S, Yu Z, Zhou W, Zheng M, Gu R, Hong J, Yang Z, Chi X, Guo G, Li X, Chen N, Huang S, Wang S, Chen JL
Cell reports 2023 Jul 25;42(7):112806
Cell reports 2023 Jul 25;42(7):112806
Schisandrin C enhances cGAS-STING pathway activation and inhibits HBV replication.
Zhao J, Xu G, Hou X, Mu W, Yang H, Shi W, Wen J, Liu T, Wu Z, Bai J, Zhang P, Wang Z, Xiao X, Zou W, Bai Z, Zhan X
Journal of ethnopharmacology 2023 Jul 15;311:116427
Journal of ethnopharmacology 2023 Jul 15;311:116427
mascRNA alleviates STING-TBK1 signaling-mediated immune response through promoting ubiquitination of STING.
Hu Y, Li X, Wang D, Mao X
Molecular immunology 2023 Feb;154:45-53
Molecular immunology 2023 Feb;154:45-53
Sirt1 Negatively Regulates Cellular Antiviral Responses by Preventing the Cytoplasmic Translocation of Interferon-Inducible Protein 16 in Human Cells.
Wang J, Qin X, Huang Y, Zhang G, Liu Y, Cui Y, Wang Y, Pei J, Ma S, Song Z, Zhu X, Wang H, Yang B
Journal of virology 2023 Feb 28;97(2):e0197522
Journal of virology 2023 Feb 28;97(2):e0197522
Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy.
Jing B, Guo F, An R, Gao Y, Li Y, Xie Y, Wang J, Chen Y, Li H, Gao T, Jin Q, Zhang L, Xie M
Journal of nanobiotechnology 2023 Feb 2;21(1):37
Journal of nanobiotechnology 2023 Feb 2;21(1):37
African swine fever virus S273R protein antagonizes type I interferon production by interfering with TBK1 and IRF3 interaction.
Li H, Zheng X, Li Y, Zhu Y, Xu Y, Yu Z, Feng WH
Virologica Sinica 2023 Dec;38(6):911-921
Virologica Sinica 2023 Dec;38(6):911-921
TBK1-stabilized ZNF268a recruits SETD4 to methylate TBK1 for efficient interferon signaling.
Liu Y, Yin W, Zeng X, Fan J, Liu C, Gao M, Huang Z, Sun G, Guo M
The Journal of biological chemistry 2023 Dec;299(12):105428
The Journal of biological chemistry 2023 Dec;299(12):105428
NSUN2-mediated M(5)c methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections.
Wang H, Feng J, Zeng C, Liu J, Fu Z, Wang D, Wang Y, Zhang L, Li J, Jiang A, He M, Cao Y, Yan K, Tang H, Guo D, Xu K, Zhou X, Zhou L, Lan K, Zhou Y, Chen Y
Emerging microbes & infections 2023 Dec;12(1):2178238
Emerging microbes & infections 2023 Dec;12(1):2178238
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production.
Wen J, Mu W, Li H, Yan Y, Zhan X, Luo W, Wang Z, Kan W, Zhao J, Hui S, He P, Qin S, Xu Y, Zhang P, Xiao X, Xu G, Bai Z
Molecular medicine (Cambridge, Mass.) 2023 Dec 8;29(1):167
Molecular medicine (Cambridge, Mass.) 2023 Dec 8;29(1):167
RNF144A promotes antiviral responses by modulating STING ubiquitination.
Yang B, Pei J, Lu C, Wang Y, Shen M, Qin X, Huang Y, Yang X, Zhao X, Ma S, Song Z, Liang Y, Wang H, Wang J
EMBO reports 2023 Dec 6;24(12):e57528
EMBO reports 2023 Dec 6;24(12):e57528
FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-β Expression through Regulating IRF-3.
Xu Z, Tian M, Tan Q, Hao P, Gao Z, Li C, Jin N
International journal of molecular sciences 2023 Dec 26;25(1)
International journal of molecular sciences 2023 Dec 26;25(1)
Metformin promotes cGAS/STING signaling pathway activation by blocking AKT phosphorylation in gastric cancer.
Shen Q, Yang L, Li C, Wang T, Lv J, Liu W, Lin Y, Yin Y, Tao K
Heliyon 2023 Aug;9(8):e18954
Heliyon 2023 Aug;9(8):e18954
A transformable nanoplatform with multiple therapeutic and immunostimulatory properties for treatment of advanced cancers.
Xue X, Qu H, Bo R, Zhang D, Zhu Z, Xiang B, Li L, Ricci M, Pan CX, Lin TY, Li Y
Biomaterials 2023 Aug;299:122145
Biomaterials 2023 Aug;299:122145
Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy.
Liu Y, Chen X, Zhao Y, Wang XY, Luo YW, Chen L, Wang W, Zhong S, Hu M, Dai Z, Jiang J, Wang X, Ji H, Cheng XX, Zheng A, Zuo J, Liu H, Ma D, Luo Z, Cao F, Hu S, Huang AL, Tang KF
Cell reports 2023 Aug 29;42(8):112852
Cell reports 2023 Aug 29;42(8):112852
A HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway.
Wu X, Xu L, Li X, Zhou Y, Han X, Zhang W, Wang W, Guo W, Liu W, Xu Q, Gu Y
Cell death & disease 2023 Aug 24;14(8):550
Cell death & disease 2023 Aug 24;14(8):550
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice.
Li L, Guo C, Yu Y, Tie L, Lu G, Liu F, Han X, Ji L, Zou X
Cell & bioscience 2023 Aug 21;13(1):154
Cell & bioscience 2023 Aug 21;13(1):154
STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages.
Liu Y, Sun Q, Zhang C, Ding M, Wang C, Zheng Q, Ma Z, Xu H, Zhou G, Wang X, Cheng Z, Xia H
iScience 2023 Aug 18;26(8):107376
iScience 2023 Aug 18;26(8):107376
WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response.
Li J, Zhang R, Wang C, Zhu J, Ren M, Jiang Y, Hou X, Du Y, Wu Q, Qi S, Li L, Chen S, Yang H, Hou F
Nature communications 2023 Aug 10;14(1):4824
Nature communications 2023 Aug 10;14(1):4824
A role of STING signaling in obesity-induced lung inflammation.
Qi Y, Wu Z, Chen D, Zhu L, Yang Y
International journal of obesity (2005) 2023 Apr;47(4):325-334
International journal of obesity (2005) 2023 Apr;47(4):325-334
DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma.
Taffoni C, Marines J, Chamma H, Guha S, Saccas M, Bouzid A, Valadao AC, Maghe C, Jardine J, Park MK, Polak K, De Martino M, Vanpouille-Box C, Del Rio M, Gongora C, Gavard J, Bidère N, Song MS, Pineau D, Hugnot JP, Kissa K, Fontenille L, Blanchet FP, Vila IK, Laguette N
The EMBO journal 2023 Apr 3;42(7):e111961
The EMBO journal 2023 Apr 3;42(7):e111961
The Papain-Like Protease of Porcine Reproductive and Respiratory Syndrome Virus Impedes STING Translocation from the Endoplasmic Reticulum to the Golgi Apparatus by Deubiquitinating STIM1.
Diao F, Bai J, Jiang C, Sun Y, Gao Y, Nauwynck H, Jiang P, Liu X
Journal of virology 2023 Apr 27;97(4):e0018823
Journal of virology 2023 Apr 27;97(4):e0018823
Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor.
Chen NN, Zhang H, Zhu QS, Zeng T, Dai W, Zhou YL, Xin GF, Wu BD, Gong SJ, Jiang ZY, You QD, Xu XL
Journal of medicinal chemistry 2023 Apr 27;66(8):5584-5610
Journal of medicinal chemistry 2023 Apr 27;66(8):5584-5610
Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis.
Ji W, Zhang L, Ma C, Xu X, Li S, Xia H, Zhou W, Liu X
Cell reports 2023 Apr 25;42(4):112327
Cell reports 2023 Apr 25;42(4):112327
Predicting the Immune Microenvironment and Prognosis with a NETosis-Related lncRNA Signature in Head and Neck Squamous Cell Carcinoma.
He X, Xiao Y, Liu S, Deng R, Li Z, Zhu X
BioMed research international 2022;2022:3191474
BioMed research international 2022;2022:3191474
Resveratrol reduces inflammatory response and detrimental effects in chronic cerebral hypoperfusion by down-regulating stimulator of interferon genes/TANK-binding kinase 1/interferon regulatory factor 3 signaling.
Kang N, Shi Y, Song J, Gao F, Fan M, Jin W, Gao Y, Lv P
Frontiers in aging neuroscience 2022;14:868484
Frontiers in aging neuroscience 2022;14:868484
Mechanism of selenomethionine inhibiting of PDCoV replication in LLC-PK1 cells based on STAT3/miR-125b-5p-1/HK2 signaling.
Ren Z, Ding T, He H, Wei Z, Shi R, Deng J
Frontiers in immunology 2022;13:952852
Frontiers in immunology 2022;13:952852
DDX56 inhibits PRV replication through regulation of IFN-β signaling pathway by targeting cGAS.
Xie J, Li X, Yang S, Yan Z, Chen L, Yang Y, Li D, Zhang X, Feng R
Frontiers in microbiology 2022;13:932842
Frontiers in microbiology 2022;13:932842
Antiviral Effect of Selenomethionine on Porcine Deltacoronavirus in Pig Kidney Epithelial Cells.
Ren Z, Jia G, He H, Ding T, Yu Y, Zuo Z, Hu Y, Zhong Z, Yu S, Deng H, Shen L, Cao S, Peng G, Wang Y, Cai D, Gou L, Ma X, Liu H, Zhou Z, Deng Y, Yang D, Deng J
Frontiers in microbiology 2022;13:846747
Frontiers in microbiology 2022;13:846747
Transcriptome Analyses of Senecavirus A-Infected PK-15 Cells: RIG-I and IRF7 Are the Important Factors in Inducing Type III Interferons.
Peng K, Deng L, Wei J, Zhao J, Deng H, Tao Q, Jiang C, Zeng Y, Li F, Zhang R, Sun X, Xu Z, Zhu L
Frontiers in microbiology 2022;13:846343
Frontiers in microbiology 2022;13:846343
Severe Acute Respiratory Syndrome Coronavirus 2 ORF8 Protein Inhibits Type I Interferon Production by Targeting HSP90B1 Signaling.
Chen J, Lu Z, Yang X, Zhou Y, Gao J, Zhang S, Huang S, Cai J, Yu J, Zhao W, Zhang B
Frontiers in cellular and infection microbiology 2022;12:899546
Frontiers in cellular and infection microbiology 2022;12:899546
Porcine Sapelovirus 3C(pro) Inhibits the Production of Type I Interferon.
Yin M, Wen W, Wang H, Zhao Q, Zhu H, Chen H, Li X, Qian P
Frontiers in cellular and infection microbiology 2022;12:852473
Frontiers in cellular and infection microbiology 2022;12:852473
Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases.
Zhao X, Yu M, Zhao Y, Zheng Y, Meng L, Du K, Xie Z, Lv H, Zhang W, Liu J, Wang Q, Yuan Y, Wang Z, Deng J
Journal of neurology 2022 Sep;269(9):4985-4996
Journal of neurology 2022 Sep;269(9):4985-4996
Phosphorylation of Ser82 on IRF3 acts as negative-feedback regulation of IRF3-dependent innate immunity.
Cheng Q, Yuan L, Guo J, Guo D, Liu X, Li S
The international journal of biochemistry & cell biology 2022 Sep;150:106275
The international journal of biochemistry & cell biology 2022 Sep;150:106275
NBR1 mediates autophagic degradation of IRF3 to negatively regulate type I interferon production.
Cai Y, Zhu Y, Zheng J, Zhang Y, Chen W
Biochemical and biophysical research communications 2022 Oct 1;623:140-147
Biochemical and biophysical research communications 2022 Oct 1;623:140-147
The A137R Protein of African Swine Fever Virus Inhibits Type I Interferon Production via the Autophagy-Mediated Lysosomal Degradation of TBK1.
Sun M, Yu S, Ge H, Wang T, Li Y, Zhou P, Pan L, Han Y, Yang Y, Sun Y, Li S, Li LF, Qiu HJ
Journal of virology 2022 May 11;96(9):e0195721
Journal of virology 2022 May 11;96(9):e0195721
RUNX1 inhibits the antiviral immune response against influenza A virus through attenuating type I interferon signaling.
Hu Y, Pan Q, Zhou K, Ling Y, Wang H, Li Y
Virology journal 2022 Mar 5;19(1):39
Virology journal 2022 Mar 5;19(1):39
Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b.
Patel SJ, Liu N, Piaker S, Gulko A, Andrade ML, Heyward FD, Sermersheim T, Edinger N, Srinivasan H, Emont MP, Westcott GP, Luther J, Chung RT, Yan S, Kumari M, Thomas R, Deleye Y, Tchernof A, White PJ, Baselli GA, Meroni M, De Jesus DF, Ahmad R, Kulkarni RN, Valenti L, Tsai L, Rosen ED
Science translational medicine 2022 Mar 23;14(637):eabh3831
Science translational medicine 2022 Mar 23;14(637):eabh3831
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus.
Zheng X, Xiao J, Jiang Q, Zheng L, Liu C, Dong C, Zheng Y, Ni P, Zhang C, Zhang F, Zhong R, Ding H, Wang Q, Qiu Y, Gao M, Ding J, Shen N, Wei B, Wang H
The EMBO journal 2022 Mar 15;41(6):e108016
The EMBO journal 2022 Mar 15;41(6):e108016
I226R Protein of African Swine Fever Virus Is a Suppressor of Innate Antiviral Responses.
Hong J, Chi X, Yuan X, Wen F, Rai KR, Wu L, Song Z, Wang S, Guo G, Chen JL
Viruses 2022 Mar 11;14(3)
Viruses 2022 Mar 11;14(3)
HAO1-mediated oxalate metabolism promotes lung pre-metastatic niche formation by inducing neutrophil extracellular traps.
Zeng Z, Xu S, Wang F, Peng X, Zhang W, Zhan Y, Ding Y, Liu Z, Liang L
Oncogene 2022 Jul;41(29):3719-3731
Oncogene 2022 Jul;41(29):3719-3731
TRIM25 inhibits influenza A virus infection, destabilizes viral mRNA, but is redundant for activating the RIG-I pathway.
Choudhury NR, Trus I, Heikel G, Wolczyk M, Szymanski J, Bolembach A, Dos Santos Pinto RM, Smith N, Trubitsyna M, Gaunt E, Digard P, Michlewski G
Nucleic acids research 2022 Jul 8;50(12):7097-7114
Nucleic acids research 2022 Jul 8;50(12):7097-7114
Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics.
Gao J, Wu Z, Zhao M, Zhang R, Li M, Sun D, Cheng H, Qi X, Shen Y, Xu Q, Chen H, Chen D, Sun Y
Acta pharmaceutica Sinica. B 2022 Jan;12(1):149-166
Acta pharmaceutica Sinica. B 2022 Jan;12(1):149-166
IKKε protects against starvation-induced NLRP3 inflammasome and pyroptosis in H9c2 cells by alleviating mitochondrial injury.
Chen G, Xu Y, Fan R, Liu Y, Yao Y, Jiang H, Wu Q, Li L, Chen W, Chen X
Biochemical and biophysical research communications 2022 Jan 22;589:267-274
Biochemical and biophysical research communications 2022 Jan 22;589:267-274
Targeting KDM4C enhances CD8(+) T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer.
Jie X, Chen Y, Zhao Y, Yang X, Xu Y, Wang J, Meng R, Zhang S, Dong X, Zhang T, Yang K, Xu S, Wu G
Journal for immunotherapy of cancer 2022 Feb;10(2)
Journal for immunotherapy of cancer 2022 Feb;10(2)
Induction of HOXA3 by Porcine Reproductive and Respiratory Syndrome Virus Inhibits Type I Interferon Response through Negative Regulation of HO-1 Transcription.
Feng Y, Guo X, Tian H, He Y, Li Y, Jiang X, Zheng H, Xiao S
Journal of virology 2022 Feb 9;96(3):e0186321
Journal of virology 2022 Feb 9;96(3):e0186321
An alternatively spliced STING isoform localizes in the cytoplasmic membrane and directly senses extracellular cGAMP.
Li X, Zhu Y, Zhang X, An X, Weng M, Shi J, Wang S, Liu C, Luo S, Zheng T
The Journal of clinical investigation 2022 Feb 1;132(3)
The Journal of clinical investigation 2022 Feb 1;132(3)
Multifaceted Effects and Mechanisms of N-Acetylcysteine on Intestinal Injury in a Porcine Epidemic Diarrhea Virus-Infected Porcine Model.
Zhang Q, Li P, Li H, Yi D, Guo S, Wang L, Zhao D, Wang C, Wu T, Hou Y
Molecular nutrition & food research 2022 Dec;66(24):e2200369
Molecular nutrition & food research 2022 Dec;66(24):e2200369
Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity.
Gao Y, Zheng X, Chang B, Lin Y, Huang X, Wang W, Ding S, Zhan W, Wang S, Xiao B, Huo L, Yu Y, Chen Y, Gong R, Wu Y, Zhang R, Zhong L, Wang X, Chen Q, Gao S, Jiang Z, Wei D, Kang T
Cell research 2022 Dec;32(12):1086-1104
Cell research 2022 Dec;32(12):1086-1104
HSP27 Attenuates cGAS-Mediated IFN-β Signaling through Ubiquitination of cGAS and Promotes PRV Infection.
Li X, Xie J, Li D, Li H, Niu Y, Wu B, Yang Y, Yan Z, Zhang X, Chen L, Feng R
Viruses 2022 Aug 23;14(9)
Viruses 2022 Aug 23;14(9)
EZH2 Inhibitor Enhances the STING Agonist‒Induced Antitumor Immunity in Melanoma.
Xu T, Dai J, Tang L, Yang L, Si L, Sheng X, Cui C, Chi Z, Kong Y, Guo J
The Journal of investigative dermatology 2022 Apr;142(4):1158-1170.e8
The Journal of investigative dermatology 2022 Apr;142(4):1158-1170.e8
Herpes simplex virus protein UL56 inhibits cGAS-Mediated DNA sensing to evade antiviral immunity.
Zheng ZQ, Fu YZ, Wang SY, Xu ZS, Zou HM, Wang YY
Cell insight 2022 Apr;1(2):100014
Cell insight 2022 Apr;1(2):100014
Heat Shock-Binding Protein 21 Regulates the Innate Immune Response to Viral Infection.
Xu Y, Yang Q, Xue B, Wang X, Tian R, Deng R, Chen S, Wang X, Wang L, Wang C, Chen J, You R, Liu Q, Li H, Wang J, Li X, Liu S, Yang D, Tang S, Zhu H
Journal of virology 2022 Apr 13;96(7):e0000122
Journal of virology 2022 Apr 13;96(7):e0000122
SARS-CoV-2 spike protein-induced cell fusion activates the cGAS-STING pathway and the interferon response.
Liu X, Wei L, Xu F, Zhao F, Huang Y, Fan Z, Mei S, Hu Y, Zhai L, Guo J, Zheng A, Cen S, Liang C, Guo F
Science signaling 2022 Apr 12;15(729):eabg8744
Science signaling 2022 Apr 12;15(729):eabg8744
HSP27 Protein Dampens Encephalomyocarditis Virus Replication by Stabilizing Melanoma Differentiation-Associated Gene 5.
Li X, Ma R, Wu B, Niu Y, Li H, Li D, Xie J, Idris A, Feng R
Frontiers in microbiology 2021;12:788870
Frontiers in microbiology 2021;12:788870
Pseudorabies Virus US3 Protein Inhibits IFN-β Production by Interacting With IRF3 to Block Its Activation.
Xie J, Zhang X, Chen L, Bi Y, Idris A, Xu S, Li X, Zhang Y, Feng R
Frontiers in microbiology 2021;12:761282
Frontiers in microbiology 2021;12:761282
PARP inhibitor niraparib as a radiosensitizer promotes antitumor immunity of radiotherapy in EGFR-mutated non-small cell lung cancer.
Zhang N, Gao Y, Zeng Z, Luo Y, Jiang X, Zhang J, Li J, Zhang J, Gong Y, Xie C
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2021 Sep;23(9):1827-1837
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2021 Sep;23(9):1827-1837
A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response.
Zhao Y, Sui L, Wu P, Wang W, Wang Z, Yu Y, Hou Z, Tan G, Liu Q, Wang G
Signal transduction and targeted therapy 2021 Sep 1;6(1):331
Signal transduction and targeted therapy 2021 Sep 1;6(1):331
Degradation of WTAP blocks antiviral responses by reducing the m(6) A levels of IRF3 and IFNAR1 mRNA.
Ge Y, Ling T, Wang Y, Jia X, Xie X, Chen R, Chen S, Yuan S, Xu A
EMBO reports 2021 Nov 4;22(11):e52101
EMBO reports 2021 Nov 4;22(11):e52101
Inhibition of Antiviral Innate Immunity by Avibirnavirus VP3 via Blocking TBK1-TRAF3 Complex Formation and IRF3 Activation.
Deng T, Hu B, Wang X, Lin L, Zhou J, Xu Y, Yan Y, Zheng X, Zhou J
mSystems 2021 May 11;6(3)
mSystems 2021 May 11;6(3)
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response.
Ma D, Yang M, Wang Q, Sun C, Shi H, Jing W, Bi Y, Shen X, Ma X, Qin Z, Lin Y, Zhu L, Zhao Y, Cheng Y, Han L
Science advances 2021 Mar;7(13)
Science advances 2021 Mar;7(13)
Staphylococcus aureus Induces IFN-β Production via a CARMA3-Independent Mechanism.
Zhou Y, Zhao S, Gao X, Jiang S, Ma J, Wang R, Li Q, Qin L, Tong Z, Wu J, Zhao J
Pathogens (Basel, Switzerland) 2021 Mar 4;10(3)
Pathogens (Basel, Switzerland) 2021 Mar 4;10(3)
Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation.
Xu G, Deng F, Zuo Q, Liu L, Dou K, Cheng Z, Cao W, Luo C, Yu C, Liu S, Zhu Y
Cellular & molecular immunology 2021 Jun;18(6):1587-1589
Cellular & molecular immunology 2021 Jun;18(6):1587-1589
Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.
Cao W, Guo Y, Cheng Z, Xu G, Zuo Q, Nie L, Huang Y, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2668-2681
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2668-2681
Caspase-1 inhibits IFN-β production via cleavage of cGAS during M. bovis infection.
Liao Y, Liu C, Wang J, Song Y, Sabir N, Hussain T, Yao J, Luo L, Wang H, Cui Y, Yang L, Zhao D, Zhou X
Veterinary microbiology 2021 Jul;258:109126
Veterinary microbiology 2021 Jul;258:109126
SPOP negatively regulates Toll-like receptor-induced inflammation by disrupting MyD88 self-association.
Hu YH, Wang Y, Wang F, Dong YM, Jiang WL, Wang YP, Zhong X, Ma LX
Cellular & molecular immunology 2021 Jul;18(7):1708-1717
Cellular & molecular immunology 2021 Jul;18(7):1708-1717
Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.
Chen X, Xu Y, Tu W, Huang F, Zuo Y, Zhang HG, Jin L, Feng Q, Ren T, He J, Miao Y, Yuan Y, Zhao Q, Liu J, Zhang R, Zhu L, Qian F, Zhu C, Zheng H, Wang J
Immunology 2021 Jul;163(3):278-292
Immunology 2021 Jul;163(3):278-292
Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.
Zuo Q, Cheng Z, Zhang G, Xia Y, Xu G, Cao W, Yang X, Fu Y, He R, Fang P, Guo Y, Nie L, Huang Y, Liu L, Zhan J, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 15;207(2):577-589
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 15;207(2):577-589
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA.
Sun H, Huang Y, Mei S, Xu F, Liu X, Zhao F, Yin L, Zhang D, Wei L, Wu C, Ma S, Wang J, Cen S, Liang C, Hu S, Guo F
Cell reports 2021 Jan 5;34(1):108586
Cell reports 2021 Jan 5;34(1):108586
Pseudorabies virus glycoprotein gE suppresses interferon-β production via CREB-binding protein degradation.
Lu M, Qiu S, Zhang L, Sun Y, Bao E, Lv Y
Virus research 2021 Jan 2;291:198220
Virus research 2021 Jan 2;291:198220
Encephalomyocarditis Virus Abrogates the Interferon Beta Signaling Pathway via Its Structural Protein VP2.
Han Y, Xie J, Xu S, Bi Y, Li X, Zhang H, Idris A, Bai J, Feng R
Journal of virology 2021 Feb 24;95(6)
Journal of virology 2021 Feb 24;95(6)
Yiguanjian decoction inhibits macrophage M1 polarization and attenuates hepatic fibrosis induced by CCl(4)/2-AAF.
Xu Y, Xu W, Liu W, Chen G, Jiang S, Chen J, Jian X, Zhang H, Liu P, Mu Y
Pharmaceutical biology 2021 Dec;59(1):1150-1160
Pharmaceutical biology 2021 Dec;59(1):1150-1160
African swine fever virus MGF505-11R inhibits type I interferon production by negatively regulating the cGAS-STING-mediated signaling pathway.
Yang K, Huang Q, Wang R, Zeng Y, Cheng M, Xue Y, Shi C, Ye L, Yang W, Jiang Y, Wang J, Huang H, Cao X, Yang G, Wang C
Veterinary microbiology 2021 Dec;263:109265
Veterinary microbiology 2021 Dec;263:109265
SRP54 Negatively Regulates IFN-Beta Production and Antiviral Response by Targeting RIG-I and MDA5.
Wang DP, Zhang HY, Liao BW, Tong Z, Xu ZS, Wang YY, Yang Y
Virologica Sinica 2021 Apr;36(2):231-240
Virologica Sinica 2021 Apr;36(2):231-240
Epstein-Barr Virus Early Protein BFRF1 Suppresses IFN-β Activity by Inhibiting the Activation of IRF3.
Wang P, Deng Y, Guo Y, Xu Z, Li Y, Ou X, Xie L, Lu M, Zhong J, Li B, Hu L, Deng S, Peng T, Cai M, Li M
Frontiers in immunology 2020;11:513383
Frontiers in immunology 2020;11:513383
Nuclear transporter karyopherin subunit alpha 3 levels modulate Porcine circovirus type 2 replication in PK-15 cells.
Zhang L, Qiu S, Lu M, Huang C, Lv Y
Virology 2020 Sep;548:31-38
Virology 2020 Sep;548:31-38
PRV UL13 inhibits cGAS-STING-mediated IFN-β production by phosphorylating IRF3.
Bo Z, Miao Y, Xi R, Zhong Q, Bao C, Chen H, Sun L, Qian Y, Jung YS, Dai J
Veterinary research 2020 Sep 15;51(1):118
Veterinary research 2020 Sep 15;51(1):118
Essential roles of S100A10 in Toll-like receptor signaling and immunity to infection.
Lou Y, Han M, Liu H, Niu Y, Liang Y, Guo J, Zhang W, Wang H
Cellular & molecular immunology 2020 Oct;17(10):1053-1062
Cellular & molecular immunology 2020 Oct;17(10):1053-1062
The Nonstructural Protein of Guertu Virus Disrupts Host Defenses by Blocking Antiviral Interferon Induction and Action.
Min YQ, Shi C, Yao T, Feng K, Mo Q, Deng F, Wang H, Ning YJ
ACS infectious diseases 2020 May 8;6(5):857-870
ACS infectious diseases 2020 May 8;6(5):857-870
Human Cytomegalovirus Protein UL94 Targets MITA to Evade the Antiviral Immune Response.
Zou HM, Huang ZF, Yang Y, Luo WW, Wang SY, Luo MH, Fu YZ, Wang YY
Journal of virology 2020 Jun 1;94(12)
Journal of virology 2020 Jun 1;94(12)
Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.
Jauhari A, Baranov SV, Suofu Y, Kim J, Singh T, Yablonska S, Li F, Wang X, Oberly P, Minnigh MB, Poloyac SM, Carlisle DL, Friedlander RM
The Journal of clinical investigation 2020 Jun 1;130(6):3124-3136
The Journal of clinical investigation 2020 Jun 1;130(6):3124-3136
SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production.
Chen K, Xiao F, Hu D, Ge W, Tian M, Wang W, Pan P, Wu K, Wu J
Viruses 2020 Dec 30;13(1)
Viruses 2020 Dec 30;13(1)
The STING-IRF3 pathway is involved in lipotoxic injury of pancreatic β cells in type 2 diabetes.
Hu HQ, Qiao JT, Liu FQ, Wang JB, Sha S, He Q, Cui C, Song J, Zang N, Wang LS, Sun Z, Chen L, Hou XG
Molecular and cellular endocrinology 2020 Dec 1;518:110890
Molecular and cellular endocrinology 2020 Dec 1;518:110890
Silica particles disorganize the polarization of pulmonary macrophages in mice.
Zhao Y, Hao C, Bao L, Wang D, Li Y, Qu Y, Ding M, Zhao A, Yao W
Ecotoxicology and environmental safety 2020 Apr 15;193:110364
Ecotoxicology and environmental safety 2020 Apr 15;193:110364
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.
Xue M, Liang H, Ji X, Liu Y, Ge Y, Hou L, Sun T
Nutrition & metabolism 2019;16:87
Nutrition & metabolism 2019;16:87
Evidence for Sexual Dimorphism in the Response to TLR3 Activation in the Developing Neonatal Mouse Brain: A Pilot Study.
Chavez-Valdez R, Mottahedin A, Stridh L, Yellowhair TR, Jantzie LL, Northington FJ, Mallard C
Frontiers in physiology 2019;10:306
Frontiers in physiology 2019;10:306
Herpes Simplex Virus Type 2 Immediate Early Protein ICP27 Inhibits IFN-β Production in Mucosal Epithelial Cells by Antagonizing IRF3 Activation.
Guan X, Zhang M, Fu M, Luo S, Hu Q
Frontiers in immunology 2019;10:290
Frontiers in immunology 2019;10:290
TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity.
Zhu W, Li J, Zhang R, Cai Y, Wang C, Qi S, Chen S, Liang X, Qi N, Hou F
The EMBO journal 2019 Sep 16;38(18):e102075
The EMBO journal 2019 Sep 16;38(18):e102075
PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing.
Hu S, Sun H, Yin L, Li J, Mei S, Xu F, Wu C, Liu X, Zhao F, Zhang D, Huang Y, Ren L, Cen S, Wang J, Liang C, Guo F
Science signaling 2019 Nov 26;12(609)
Science signaling 2019 Nov 26;12(609)
A Subcellular Quantitative Proteomic Analysis of Herpes Simplex Virus Type 1-Infected HEK 293T Cells.
Wan W, Wang L, Chen X, Zhu S, Shang W, Xiao G, Zhang LK
Molecules (Basel, Switzerland) 2019 Nov 20;24(23)
Molecules (Basel, Switzerland) 2019 Nov 20;24(23)
ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner.
Su Z, Dziedzic SA, Hu D, Barrett VJ, Broekema N, Li W, Qian L, Jia N, Ofengeim D, Najafov A, Zhu H, Knipe DM, Yuan J
Cell death and differentiation 2019 Jun;26(6):1077-1088
Cell death and differentiation 2019 Jun;26(6):1077-1088
The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death.
Zierhut C, Yamaguchi N, Paredes M, Luo JD, Carroll T, Funabiki H
Cell 2019 Jul 11;178(2):302-315.e23
Cell 2019 Jul 11;178(2):302-315.e23
Host HDAC4 regulates the antiviral response by inhibiting the phosphorylation of IRF3.
Yang Q, Tang J, Pei R, Gao X, Guo J, Xu C, Wang Y, Wang Q, Wu C, Zhou Y, Hu X, Zhao H, Wang Y, Chen X, Chen J
Journal of molecular cell biology 2019 Feb 1;11(2):158-169
Journal of molecular cell biology 2019 Feb 1;11(2):158-169
Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex.
Xu G, Xia Z, Deng F, Liu L, Wang Q, Yu Y, Wang F, Zhu C, Liu W, Cheng Z, Zhu Y, Zhou L, Zhang Y, Lu M, Liu S
PLoS pathogens 2019 Aug;15(8):e1008002
PLoS pathogens 2019 Aug;15(8):e1008002
Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death.
Sanjo H, Nakayama J, Yoshizawa T, Fehling HJ, Akira S, Taki S
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):783-788
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):783-788
NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1.
Xia Z, Xu G, Nie L, Liu L, Peng N, He Q, Zuo Q, Zhou Y, Cao Z, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):1001-1011
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):1001-1011
PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria.
Gao X, Chen D, Hu X, Zhou Y, Wang Y, Wu C, Chen J, Wang Y, Pei R, Chen X
Journal of innate immunity 2018;10(4):315-327
Journal of innate immunity 2018;10(4):315-327
STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation.
Cao Q, Juan CX, Zhang DQ, He J, Cao YZ, Pasha AB, Wang JY, Qi HX, Li S, Jin R, Zhou GP
Experimental cell research 2018 Sep 15;370(2):498-505
Experimental cell research 2018 Sep 15;370(2):498-505
USP7-TRIM27 axis negatively modulates antiviral type I IFN signaling.
Cai J, Chen HY, Peng SJ, Meng JL, Wang Y, Zhou Y, Qian XP, Sun XY, Pang XW, Zhang Y, Zhang J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Oct;32(10):5238-5249
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Oct;32(10):5238-5249
Inhibition of cGAS-STING-TBK1 signaling pathway by DP96R of ASFV China 2018/1.
Wang X, Wu J, Wu Y, Chen H, Zhang S, Li J, Xin T, Jia H, Hou S, Jiang Y, Zhu H, Guo X
Biochemical and biophysical research communications 2018 Nov 30;506(3):437-443
Biochemical and biophysical research communications 2018 Nov 30;506(3):437-443
MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.
Zhou P, Ding X, Wan X, Liu L, Yuan X, Zhang W, Hui X, Meng G, Xiao H, Li B, Zhong J, Hou F, Deng L, Zhang Y
Nature communications 2018 Mar 28;9(1):1243
Nature communications 2018 Mar 28;9(1):1243
Dampened STING-Dependent Interferon Activation in Bats.
Xie J, Li Y, Shen X, Goh G, Zhu Y, Cui J, Wang LF, Shi ZL, Zhou P
Cell host & microbe 2018 Mar 14;23(3):297-301.e4
Cell host & microbe 2018 Mar 14;23(3):297-301.e4
Tick-Borne Encephalitis Virus Nonstructural Protein NS5 Induces RANTES Expression Dependent on the RNA-Dependent RNA Polymerase Activity.
Zheng Z, Yang J, Jiang X, Liu Y, Zhang X, Li M, Zhang M, Fu M, Hu K, Wang H, Luo MH, Gong P, Hu Q
Journal of immunology (Baltimore, Md. : 1950) 2018 Jul 1;201(1):53-68
Journal of immunology (Baltimore, Md. : 1950) 2018 Jul 1;201(1):53-68
PTEN-L promotes type I interferon responses and antiviral immunity.
Cao Y, Wang H, Yang L, Zhang Z, Li C, Yuan X, Bu L, Chen L, Chen Y, Li CM, Guo D
Cellular & molecular immunology 2018 Jan;15(1):48-57
Cellular & molecular immunology 2018 Jan;15(1):48-57
Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3.
Yi C, Zhao Z, Wang S, Sun X, Zhang D, Sun X, Zhang A, Jin M
Frontiers in immunology 2017;8:1051
Frontiers in immunology 2017;8:1051
The Central Role of IFI204 in IFN-β Release and Autophagy Activation during Mycobacterium bovis Infection.
Chunfa L, Xin S, Qiang L, Sreevatsan S, Yang L, Zhao D, Zhou X
Frontiers in cellular and infection microbiology 2017;7:169
Frontiers in cellular and infection microbiology 2017;7:169
Capsular Polysaccharide is a Main Component of Mycoplasma ovipneumoniae in the Pathogen-Induced Toll-Like Receptor-Mediated Inflammatory Responses in Sheep Airway Epithelial Cells.
Jiang Z, Song F, Li Y, Xue D, Deng G, Li M, Liu X, Wang Y
Mediators of inflammation 2017;2017:9891673
Mediators of inflammation 2017;2017:9891673
West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5.
Zhang HL, Ye HQ, Liu SQ, Deng CL, Li XD, Shi PY, Zhang B
Journal of virology 2017 Sep 15;91(18)
Journal of virology 2017 Sep 15;91(18)
Porcine 2', 5'-oligoadenylate synthetase 2 inhibits porcine reproductive and respiratory syndrome virus replication in vitro.
Zhao M, Wan B, Li H, He J, Chen X, Wang L, Wang Y, Xie S, Qiao S, Zhang G
Microbial pathogenesis 2017 Oct;111:14-21
Microbial pathogenesis 2017 Oct;111:14-21
Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β.
Bakshi S, Taylor J, Strickson S, McCartney T, Cohen P
The Biochemical journal 2017 Mar 15;474(7):1163-1174
The Biochemical journal 2017 Mar 15;474(7):1163-1174
TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity.
Lang X, Tang T, Jin T, Ding C, Zhou R, Jiang W
The Journal of experimental medicine 2017 Feb;214(2):459-473
The Journal of experimental medicine 2017 Feb;214(2):459-473
Decreased expression of STING predicts poor prognosis in patients with gastric cancer.
Song S, Peng P, Tang Z, Zhao J, Wu W, Li H, Shao M, Li L, Yang C, Duan F, Zhang M, Zhang J, Wu H, Li C, Wang X, Wang H, Ruan Y, Gu J
Scientific reports 2017 Feb 8;7:39858
Scientific reports 2017 Feb 8;7:39858
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
Lian S, Guo J, Wang L, Li W, Wang J, Ji H, Kong F, Xu B, Li S, Yang H
Oncotarget 2017 Dec 29;8(70):115304-115314
Oncotarget 2017 Dec 29;8(70):115304-115314
GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome.
Nie Y, Ran Y, Zhang HY, Huang ZF, Pan ZY, Wang SY, Wang YY
PLoS pathogens 2017 Apr;13(4):e1006328
PLoS pathogens 2017 Apr;13(4):e1006328
The tumor suppressor PTEN has a critical role in antiviral innate immunity.
Li S, Zhu M, Pan R, Fang T, Cao YY, Chen S, Zhao X, Lei CQ, Guo L, Chen Y, Li CM, Jokitalo E, Yin Y, Shu HB, Guo D
Nature immunology 2016 Mar;17(3):241-9
Nature immunology 2016 Mar;17(3):241-9
AIM2 inhibits autophagy and IFN-β production during M. bovis infection.
Liu C, Yue R, Yang Y, Cui Y, Yang L, Zhao D, Zhou X
Oncotarget 2016 Jul 26;7(30):46972-46987
Oncotarget 2016 Jul 26;7(30):46972-46987
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response.
Zeng LP, Gao YT, Ge XY, Zhang Q, Peng C, Yang XL, Tan B, Chen J, Chmura AA, Daszak P, Shi ZL
Journal of virology 2016 Jul 15;90(14):6573-6582
Journal of virology 2016 Jul 15;90(14):6573-6582
Attenuation of cerebral ischemic injury in interferon regulatory factor 3-deficient rat.
Li L, Qin JJ, Guo S, Zhang P, Gong J, Zhang XJ, Zheng A, Xia H, Li H
Journal of neurochemistry 2016 Feb;136(4):871-883
Journal of neurochemistry 2016 Feb;136(4):871-883
Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway.
Zhang X, Zheng Z, Liu X, Shu B, Mao P, Bai B, Hu Q, Luo M, Ma X, Cui Z, Wang H
Journal of neuroinflammation 2016 Aug 30;13(1):209
Journal of neuroinflammation 2016 Aug 30;13(1):209
Vinexin-β deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis.
Li M, Guo S, Zhang P, Gong J, Zheng A, Zhang Y, Li H
Journal of neurochemistry 2015 Jul;134(2):211-21
Journal of neurochemistry 2015 Jul;134(2):211-21
Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA-Binding Activity of IFN Regulatory Factor 3.
Zhu M, Fang T, Li S, Meng K, Guo D
Journal of immunology (Baltimore, Md. : 1950) 2015 Jul 1;195(1):289-97
Journal of immunology (Baltimore, Md. : 1950) 2015 Jul 1;195(1):289-97
HSV-2 immediate-early protein US1 inhibits IFN-β production by suppressing association of IRF-3 with IFN-β promoter.
Zhang M, Liu Y, Wang P, Guan X, He S, Luo S, Li C, Hu K, Jin W, Du T, Yan Y, Zhang Z, Zheng Z, Wang H, Hu Q
Journal of immunology (Baltimore, Md. : 1950) 2015 Apr 1;194(7):3102-15
Journal of immunology (Baltimore, Md. : 1950) 2015 Apr 1;194(7):3102-15
An alternative splicing isoform of MITA antagonizes MITA-mediated induction of type I IFNs.
Chen H, Pei R, Zhu W, Zeng R, Wang Y, Wang Y, Lu M, Chen X
Journal of immunology (Baltimore, Md. : 1950) 2014 Feb 1;192(3):1162-70
Journal of immunology (Baltimore, Md. : 1950) 2014 Feb 1;192(3):1162-70
Protein phosphatase PP1 negatively regulates the Toll-like receptor- and RIG-I-like receptor-triggered production of type I interferon by inhibiting IRF3 phosphorylation at serines 396 and 385 in macrophage.
Gu M, Zhang T, lin W, Liu Z, Lai R, Xia D, Huang H, Wang X
Cellular signalling 2014 Dec;26(12):2930-9
Cellular signalling 2014 Dec;26(12):2930-9
HnRNP A1/A2 and SF2/ASF regulate alternative splicing of interferon regulatory factor-3 and affect immunomodulatory functions in human non-small cell lung cancer cells.
Guo R, Li Y, Ning J, Sun D, Lin L, Liu X
PloS one 2013;8(4):e62729
PloS one 2013;8(4):e62729
Human bocavirus VP2 upregulates IFN-β pathway by inhibiting ring finger protein 125-mediated ubiquitination of retinoic acid-inducible gene-I.
Luo H, Zhang Z, Zheng Z, Ke X, Zhang X, Li Q, Liu Y, Bai B, Mao P, Hu Q, Wang H
Journal of immunology (Baltimore, Md. : 1950) 2013 Jul 15;191(2):660-9
Journal of immunology (Baltimore, Md. : 1950) 2013 Jul 15;191(2):660-9
Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities.
Zhou P, Li H, Wang H, Wang LF, Shi Z
The Journal of general virology 2012 Feb;93(Pt 2):275-281
The Journal of general virology 2012 Feb;93(Pt 2):275-281
Human bocavirus NP1 inhibits IFN-β production by blocking association of IFN regulatory factor 3 with IFNB promoter.
Zhang Z, Zheng Z, Luo H, Meng J, Li H, Li Q, Zhang X, Ke X, Bai B, Mao P, Hu Q, Wang H
Journal of immunology (Baltimore, Md. : 1950) 2012 Aug 1;189(3):1144-53
Journal of immunology (Baltimore, Md. : 1950) 2012 Aug 1;189(3):1144-53
Varicella-zoster virus immediate-early protein ORF61 abrogates the IRF3-mediated innate immune response through degradation of activated IRF3.
Zhu H, Zheng C, Xing J, Wang S, Li S, Lin R, Mossman KL
Journal of virology 2011 Nov;85(21):11079-89
Journal of virology 2011 Nov;85(21):11079-89
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 11312-1-AP(IRF3 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using IRF3 antibody 11312-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 11312-1-AP(IRF3 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 11312-1-AP(IRF3 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue