PTPN23

This gene encodes a member of the non-receptor type protein-tyrosine phosphatase family. The encoded protein may be involved in the regulation of small nuclear ribonucleo protein assembly and pre-mRNA splicing by modifying the survival motor neuron (SMN) complex. The encoded protein additionally plays a role in ciliogenesis and is part of endosomal sorting complex required for transport (ESCRT) pathways. This gene may serve a tumor suppressor function. [provided by RefSeq, Jul 2016]

Description

Protein tyrosine phosphatase non-receptor type 23

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear bodies, Vesicles

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (47381011 - 47413435)

Ensembl ID

ENSG00000076201  (ver. 103.38)

Orthologs

Mouse Ptpn23: ENSMUSG00000036057

UniProt

Q9H3S7

neXtProt

NX_Q9H3S7

Human splice variants
Mouse splice variants

Protein structure