Antibody data
- Antibody Data
- Antigen structure
- References [41]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 15112-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15112-1-AP, RRID:AB_2070016
- Product name
- CAPRIN1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CAPRIN1 antibody (Cat. #15112-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references High-fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate.
Defining the Caprin-1 Interactome in Unstressed and Stressed Conditions.
Arabidopsis thaliana G3BP Ortholog Rescues Mammalian Stress Granule Phenotype across Kingdoms.
In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs.
SNHG9 was upregulated in NSCLC and associated with DDP-resistance and poor prognosis of NSCLC patients.
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.
Partners of wild type Grb7 and a mutant lacking its calmodulin-binding domain.
Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance.
G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules.
Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization.
Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD.
The Acetylation of Lysine-376 of G3BP1 Regulates RNA Binding and Stress Granule Dynamics.
ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.
miR-193a/b-3p relieves hepatic fibrosis and restrains proliferation and activation of hepatic stellate cells.
Inducible degradation of lncRNA Sros1 promotes IFN-γ-mediated activation of innate immune responses by stabilizing Stat1 mRNA.
Drug-induced Stress Granule Formation Protects Sensory Hair Cells in Mouse Cochlear Explants During Ototoxicity.
TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types.
Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability.
Identification and characterization of host proteins bound to dengue virus 3' UTR reveal an antiviral role for quaking proteins.
Mammalian Orthoreovirus Factories Modulate Stress Granule Protein Localization by Interaction with G3BP1.
Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral Activity.
Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells.
Proteomic analysis of FUS interacting proteins provides insights into FUS function and its role in ALS.
G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.
The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches.
Stress granules and RNA processing bodies are novel autoantibody targets in systemic sclerosis.
YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression.
Deficiency of the RNA binding protein caprin2 causes lens defects and features of Peters anomaly.
Methods for the characterization of stress granules in virus infected cells.
Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget.
G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA.
UVC-induced stress granules in mammalian cells.
Activation of stress response pathways promotes formation of antiviral granules and restricts virus replication.
CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation.
Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling.
Japanese encephalitis virus core protein inhibits stress granule formation through an interaction with Caprin-1 and facilitates viral propagation.
Fragile X mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes [corrected].
Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition.
Formation of antiviral cytoplasmic granules during orthopoxvirus infection.
Angiogenin-induced tRNA fragments inhibit translation initiation.
OGFOD1, a novel modulator of eukaryotic translation initiation factor 2alpha phosphorylation and the cellular response to stress.
Freibaum BD, Messing J, Yang P, Kim HJ, Taylor JP
The Journal of cell biology 2021 Mar 1;220(3)
The Journal of cell biology 2021 Mar 1;220(3)
Defining the Caprin-1 Interactome in Unstressed and Stressed Conditions.
Vu L, Ghosh A, Tran C, Tebung WA, Sidibé H, Garcia-Mansfield K, David-Dirgo V, Sharma R, Pirrotte P, Bowser R, Vande Velde C
Journal of proteome research 2021 Jun 4;20(6):3165-3178
Journal of proteome research 2021 Jun 4;20(6):3165-3178
Arabidopsis thaliana G3BP Ortholog Rescues Mammalian Stress Granule Phenotype across Kingdoms.
Reuper H, Götte B, Williams L, Tan TJC, McInerney GM, Panas MD, Krenz B
International journal of molecular sciences 2021 Jun 11;22(12)
International journal of molecular sciences 2021 Jun 11;22(12)
In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs.
Sun L, Li P, Ju X, Rao J, Huang W, Ren L, Zhang S, Xiong T, Xu K, Zhou X, Gong M, Miska E, Ding Q, Wang J, Zhang QC
Cell 2021 Apr 1;184(7):1865-1883.e20
Cell 2021 Apr 1;184(7):1865-1883.e20
SNHG9 was upregulated in NSCLC and associated with DDP-resistance and poor prognosis of NSCLC patients.
Wang R, Chen C, Kang W, Meng G
American journal of translational research 2020;12(8):4456-4466
American journal of translational research 2020;12(8):4456-4466
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.
Valdez-Sinon AN, Lai A, Shi L, Lancaster CL, Gokhale A, Faundez V, Bassell GJ
iScience 2020 May 22;23(5):101132
iScience 2020 May 22;23(5):101132
Partners of wild type Grb7 and a mutant lacking its calmodulin-binding domain.
García-Palmero I, Shah N, Ali NA, Daly RJ, Wilce JA, Villalobo A
Archives of biochemistry and biophysics 2020 Jul 15;687:108386
Archives of biochemistry and biophysics 2020 Jul 15;687:108386
Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance.
Lee AK, Klein J, Fon Tacer K, Lord T, Oatley MJ, Oatley JM, Porter SN, Pruett-Miller SM, Tikhonova EB, Karamyshev AL, Wang YD, Yang P, Korff A, Kim HJ, Taylor JP, Potts PR
Molecular cell 2020 Aug 20;79(4):645-659.e9
Molecular cell 2020 Aug 20;79(4):645-659.e9
G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules.
Yang P, Mathieu C, Kolaitis RM, Zhang P, Messing J, Yurtsever U, Yang Z, Wu J, Li Y, Pan Q, Yu J, Martin EW, Mittag T, Kim HJ, Taylor JP
Cell 2020 Apr 16;181(2):325-345.e28
Cell 2020 Apr 16;181(2):325-345.e28
Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization.
Sanders DW, Kedersha N, Lee DSW, Strom AR, Drake V, Riback JA, Bracha D, Eeftens JM, Iwanicki A, Wang A, Wei MT, Whitney G, Lyons SM, Anderson P, Jacobs WM, Ivanov P, Brangwynne CP
Cell 2020 Apr 16;181(2):306-324.e28
Cell 2020 Apr 16;181(2):306-324.e28
Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD.
Fang MY, Markmiller S, Vu AQ, Javaherian A, Dowdle WE, Jolivet P, Bushway PJ, Castello NA, Baral A, Chan MY, Linsley JW, Linsley D, Mercola M, Finkbeiner S, Lecuyer E, Lewcock JW, Yeo GW
Neuron 2019 Sep 4;103(5):802-819.e11
Neuron 2019 Sep 4;103(5):802-819.e11
The Acetylation of Lysine-376 of G3BP1 Regulates RNA Binding and Stress Granule Dynamics.
Gal J, Chen J, Na DY, Tichacek L, Barnett KR, Zhu H
Molecular and cellular biology 2019 Nov 15;39(22)
Molecular and cellular biology 2019 Nov 15;39(22)
ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.
Wang B, Maxwell BA, Joo JH, Gwon Y, Messing J, Mishra A, Shaw TI, Ward AL, Quan H, Sakurada SM, Pruett-Miller SM, Bertorini T, Vogel P, Kim HJ, Peng J, Taylor JP, Kundu M
Molecular cell 2019 May 16;74(4):742-757.e8
Molecular cell 2019 May 16;74(4):742-757.e8
miR-193a/b-3p relieves hepatic fibrosis and restrains proliferation and activation of hepatic stellate cells.
Ju B, Nie Y, Yang X, Wang X, Li F, Wang M, Wang C, Zhang H
Journal of cellular and molecular medicine 2019 Jun;23(6):3824-3832
Journal of cellular and molecular medicine 2019 Jun;23(6):3824-3832
Inducible degradation of lncRNA Sros1 promotes IFN-γ-mediated activation of innate immune responses by stabilizing Stat1 mRNA.
Xu H, Jiang Y, Xu X, Su X, Liu Y, Ma Y, Zhao Y, Shen Z, Huang B, Cao X
Nature immunology 2019 Dec;20(12):1621-1630
Nature immunology 2019 Dec;20(12):1621-1630
Drug-induced Stress Granule Formation Protects Sensory Hair Cells in Mouse Cochlear Explants During Ototoxicity.
Gonçalves AC, Towers ER, Haq N, Porco JA Jr, Pelletier J, Dawson SJ, Gale JE
Scientific reports 2019 Aug 29;9(1):12501
Scientific reports 2019 Aug 29;9(1):12501
TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types.
Khalfallah Y, Kuta R, Grasmuck C, Prat A, Durham HD, Vande Velde C
Scientific reports 2018 May 15;8(1):7551
Scientific reports 2018 May 15;8(1):7551
Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability.
Kuliyev E, Gingras S, Guy CS, Howell S, Vogel P, Pelletier S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Mar 7;38(10):2615-2630
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Mar 7;38(10):2615-2630
Identification and characterization of host proteins bound to dengue virus 3' UTR reveal an antiviral role for quaking proteins.
Liao KC, Chuo V, Ng WC, Neo SP, Pompon J, Gunaratne J, Ooi EE, Garcia-Blanco MA
RNA (New York, N.Y.) 2018 Jun;24(6):803-814
RNA (New York, N.Y.) 2018 Jun;24(6):803-814
Mammalian Orthoreovirus Factories Modulate Stress Granule Protein Localization by Interaction with G3BP1.
Choudhury P, Bussiere LD, Miller CL
Journal of virology 2017 Nov 1;91(21)
Journal of virology 2017 Nov 1;91(21)
Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral Activity.
Yang CW, Lee YZ, Hsu HY, Shih C, Chao YS, Chang HY, Lee SJ
Scientific reports 2017 Jun 22;7(1):4105
Scientific reports 2017 Jun 22;7(1):4105
Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells.
Basu M, Courtney SC, Brinton MA
PLoS pathogens 2017 Feb;13(2):e1006240
PLoS pathogens 2017 Feb;13(2):e1006240
Proteomic analysis of FUS interacting proteins provides insights into FUS function and its role in ALS.
Kamelgarn M, Chen J, Kuang L, Arenas A, Zhai J, Zhu H, Gal J
Biochimica et biophysica acta 2016 Oct;1862(10):2004-14
Biochimica et biophysica acta 2016 Oct;1862(10):2004-14
G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.
Kedersha N, Panas MD, Achorn CA, Lyons S, Tisdale S, Hickman T, Thomas M, Lieberman J, McInerney GM, Ivanov P, Anderson P
The Journal of cell biology 2016 Mar 28;212(7):845-60
The Journal of cell biology 2016 Mar 28;212(7):845-60
The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches.
Mineo M, Ricklefs F, Rooj AK, Lyons SM, Ivanov P, Ansari KI, Nakano I, Chiocca EA, Godlewski J, Bronisz A
Cell reports 2016 Jun 14;15(11):2500-9
Cell reports 2016 Jun 14;15(11):2500-9
Stress granules and RNA processing bodies are novel autoantibody targets in systemic sclerosis.
Johnson ME, Grassetti AV, Taroni JN, Lyons SM, Schweppe D, Gordon JK, Spiera RF, Lafyatis R, Anderson PJ, Gerber SA, Whitfield ML
Arthritis research & therapy 2016 Jan 22;18:27
Arthritis research & therapy 2016 Jan 22;18:27
YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression.
Lyons SM, Achorn C, Kedersha NL, Anderson PJ, Ivanov P
Nucleic acids research 2016 Aug 19;44(14):6949-60
Nucleic acids research 2016 Aug 19;44(14):6949-60
Deficiency of the RNA binding protein caprin2 causes lens defects and features of Peters anomaly.
Dash S, Dang CA, Beebe DC, Lachke SA
Developmental dynamics : an official publication of the American Association of Anatomists 2015 Oct;244(10):1313-27
Developmental dynamics : an official publication of the American Association of Anatomists 2015 Oct;244(10):1313-27
Methods for the characterization of stress granules in virus infected cells.
Panas MD, Kedersha N, McInerney GM
Methods (San Diego, Calif.) 2015 Nov 15;90:57-64
Methods (San Diego, Calif.) 2015 Nov 15;90:57-64
Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget.
Qiu YQ, Yang CW, Lee YZ, Yang RB, Lee CH, Hsu HY, Chang CC, Lee SJ
Oncotarget 2015 Feb 10;6(4):2148-63
Oncotarget 2015 Feb 10;6(4):2148-63
G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA.
Aulas A, Caron G, Gkogkas CG, Mohamed NV, Destroismaisons L, Sonenberg N, Leclerc N, Parker JA, Vande Velde C
The Journal of cell biology 2015 Apr 13;209(1):73-84
The Journal of cell biology 2015 Apr 13;209(1):73-84
UVC-induced stress granules in mammalian cells.
Moutaoufik MT, El Fatimy R, Nassour H, Gareau C, Lang J, Tanguay RM, Mazroui R, Khandjian EW
PloS one 2014;9(11):e112742
PloS one 2014;9(11):e112742
Activation of stress response pathways promotes formation of antiviral granules and restricts virus replication.
Rozelle DK, Filone CM, Kedersha N, Connor JH
Molecular and cellular biology 2014 Jun;34(11):2003-16
Molecular and cellular biology 2014 Jun;34(11):2003-16
CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation.
De Rubeis S, Pasciuto E, Li KW, Fernández E, Di Marino D, Buzzi A, Ostroff LE, Klann E, Zwartkruis FJ, Komiyama NH, Grant SG, Poujol C, Choquet D, Achsel T, Posthuma D, Smit AB, Bagni C
Neuron 2013 Sep 18;79(6):1169-82
Neuron 2013 Sep 18;79(6):1169-82
Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling.
Simeoni F, Tasselli L, Tanaka S, Villanova L, Hayashi M, Kubota K, Isono F, Garcia BA, Michishita-Kioi E, Chua KF
Scientific reports 2013 Oct 30;3:3085
Scientific reports 2013 Oct 30;3:3085
Japanese encephalitis virus core protein inhibits stress granule formation through an interaction with Caprin-1 and facilitates viral propagation.
Katoh H, Okamoto T, Fukuhara T, Kambara H, Morita E, Mori Y, Kamitani W, Matsuura Y
Journal of virology 2013 Jan;87(1):489-502
Journal of virology 2013 Jan;87(1):489-502
Fragile X mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes [corrected].
El Fatimy R, Tremblay S, Dury AY, Solomon S, De Koninck P, Schrader JW, Khandjian EW
PloS one 2012;7(6):e39338
PloS one 2012;7(6):e39338
Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition.
Drougat L, Olivier-Van Stichelen S, Mortuaire M, Foulquier F, Lacoste AS, Michalski JC, Lefebvre T, Vercoutter-Edouart AS
Biochimica et biophysica acta 2012 Dec;1820(12):1839-48
Biochimica et biophysica acta 2012 Dec;1820(12):1839-48
Formation of antiviral cytoplasmic granules during orthopoxvirus infection.
Simpson-Holley M, Kedersha N, Dower K, Rubins KH, Anderson P, Hensley LE, Connor JH
Journal of virology 2011 Feb;85(4):1581-93
Journal of virology 2011 Feb;85(4):1581-93
Angiogenin-induced tRNA fragments inhibit translation initiation.
Ivanov P, Emara MM, Villen J, Gygi SP, Anderson P
Molecular cell 2011 Aug 19;43(4):613-23
Molecular cell 2011 Aug 19;43(4):613-23
OGFOD1, a novel modulator of eukaryotic translation initiation factor 2alpha phosphorylation and the cellular response to stress.
Wehner KA, Schütz S, Sarnow P
Molecular and cellular biology 2010 Apr;30(8):2006-16
Molecular and cellular biology 2010 Apr;30(8):2006-16
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CAPRIN1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CAPRIN1. This antibody recognizes human,mouse,rat antigen. The CAPRIN1 antibody has been validated for the following applications: ELISA, IHC, IP, WB, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells using 15112-1-AP( CAPRIN1 Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-CAPRIN1 (IP:15112-1-AP, 3ug; Detection:15112-1-AP 1:300) with HeLa cells lysate 2500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 15112-1-AP(CAPRIN1 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 15112-1-AP(CAPRIN1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue