AMM03287G

antibody from Leading Biology

Targeting: BIN1 AMPH2, AMPHL, SH3P9

Western blot (Recommended by provider)

Antibody Data

Product number

AMM03287G

Provider

Leading Biology

Product name

BIN1 Antibody (monoclonal) (M01)

Antibody type

Monoclonal

Description

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Reactivity

Human

Host

Mouse

Isotype

IgG

Antibody clone number

1H1

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.