60137
antibody from STEMCELL Technologies Inc
Targeting: MUC1
ADMCKD, ADMCKD1, CD227, MCD, MCKD, MCKD1, PEM, PUM
Antibody data
- Antibody Data
- Antigen structure
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- Product number
- 60137 - Provider product page
- Provider
- STEMCELL Technologies Inc
- Product name
- Anti-Human MUC1 (CD227) Antibody, Clone 214D4
- Antibody type
- Monoclonal
- Description
- The 214D4 antibody reacts with MUC1 (also known as CD227), a large cell surface glycoprotein expressed by most glandular and ductal epithelial cells as well as a variety of hematopoietic cells. A characteristic feature of the MUC1 glycoprotein is a core protein domain composed of a variable number of tandem repeats and multiple oligosaccharide side chains. Because the extracellular portion of MUC1 can extend beyond most cell surface proteins, it is thought to play a role in cell-cell and cell-substrate adhesion. The protein is highly expressed by the majority of human adenocarcinomas and is associated with a poor prognosis. In the mammary gland, MUC1 is localized on the apical plasma membrane of luminal epithelial cells. The 214D4 antibody clone is particularly useful since it enriches for luminal-restricted but not bipotent epithelial progenitor cells from normal human mammary tissue.
- Reactivity
- Human
- Host
- Human
- Isotype
- IgG
- Vial size
- 200 µg
- Storage
- -20°C
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