FNab08015

antibody from FineTest Biotech

Targeting: SMARCE1 BAF57

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

FNab08015

Provider

FineTest Biotech

Product name

SMARCE1 antibody

Antibody type

Monoclonal

Antigen

Recombinant protein fragment

Description

Involved in transcriptional activation and repression of select genes by chromatin remodeling(alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex(npBAF complex) and the neuron-specific chromatin remodeling complex(nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes(nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth(By similarity). Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases(HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

SWI/SNF related, matrix associated,
actin dependent regulator of chrom
atin, subfamily e, member 1


Epitope

IgG1

Isotype

IgG

Antibody clone number

1G10

Vial size

100¦Ìg

Concentration

Protein A+G purification

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)

Handling

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)