BS8384

antibody from Bioworld Technology, Inc

Targeting: RPA3 REPA3

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS8384

Provider

Bioworld Technology, Inc

Product name

RPA3 polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human RPA3.

Description

The single-stranded-DNA-binding proteins (SSBs) are essential for DNA function in prokaryotic and eukaryotic cells, mitochondria, phages and viruses. Replication protein A (RPA), a highly conserved eukaryotic protein, is a heterotrimeric SSB that is composed of three subunits, designated RPA 14 kDa (also known as RPA3), RPA 32 kDa and RPA 70 kDa. Together, these subunits play an important role in DNA replication, recombination and repair. RPA is one of the major damage-recognition structures involved in the early stage of nucleotide excision repair and may play a role in telomere maintenance. The binding of human RPA (hRPA) to DNA involves molecular polarity, in which initial hRPA binding occurs on the 5£ª side of a ssDNA substrate and then extends in the 3£ª direction to create a stably bound hRPA. The RPA 14 kDa subunit localizes to the nucleus and is the smallest component of the RPA complex, functioning with the other subunits to regulate various aspects of DNA metabolism.

Reactivity

Human

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.