Antibody data
- Antibody Data
- Antigen structure
- References [35]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 14508-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14508-1-AP, RRID:AB_2194235
- Product name
- SREBF2 antibody
- Antibody type
- Polyclonal
- Description
- SREBF2 antibody (Cat. #14508-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer.
Betaine supplementation alleviates corticosterone-induced hepatic cholesterol accumulation through epigenetic modulation of HMGCR and CYP7A1 genes in laying hens.
CCR9 overexpression promotes T-ALL progression by enhancing cholesterol biosynthesis.
miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway.
Inflammation Induced by Lipopolysaccharide and Palmitic Acid Increases Cholesterol Accumulation via Enhancing Myeloid Differentiation Factor 88 Expression in HepG2 Cells.
Ethyl acetate extract of sappanwood alleviates experimental atherosclerosis in rats through changes in FGF21 and SREBP-2 expression.
Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.
Maternal betaine supplementation decreases hepatic cholesterol deposition in chicken offspring with epigenetic modulation of SREBP2 and CYP7A1 genes.
Apigenin reduces the excessive accumulation of lipids induced by palmitic acid via the AMPK signaling pathway in HepG2 cells.
OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signalling pathway.
Hydrogen sulfide inhibits PCSK9 expression through the PI3K/Akt‑SREBP‑2 signaling pathway to influence lipid metabolism in HepG2 cells.
Lonicera caerulea Berry Polyphenols Activate SIRT1, Enhancing Inhibition of Raw264.7 Macrophage Foam Cell Formation and Promoting Cholesterol Efflux.
SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target.
Prenatal exposure to diesel exhaust PM(2.5) programmed non-alcoholic fatty liver disease differently in adult male offspring of mice fed normal chow and a high-fat diet.
Cholesterol-lowering effects and potential mechanisms of chitooligosaccharide capsules in hyperlipidemic rats.
6-Gingerol Ameliorates Behavioral Changes and Atherosclerotic Lesions in ApoE(-/-) Mice Exposed to Chronic Mild Stress.
Intracellular hepatitis B virus increases hepatic cholesterol deposition in alcoholic fatty liver via hepatitis B core protein.
Flavonoids extracted from Linaria vulgaris protect against hyperlipidemia and hepatic steatosis induced by western-type diet in mice.
Red algae (Gelidium amansii) hot-water extract ameliorates lipid metabolism in hamsters fed a high-fat diet.
Prenatal betaine exposure alleviates corticosterone-induced inhibition of CYP27A1 expression in the liver of juvenile chickens associated with its promoter DNA methylation.
Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.
TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis.
VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.
Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice.
RP5-833A20.1/miR-382-5p/NFIA-dependent signal transduction pathway contributes to the regulation of cholesterol homeostasis and inflammatory reaction.
Potent effects of dioscin against obesity in mice.
The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters.
The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1.
Protective effects of dioscin against alcohol-induced liver injury.
The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis.
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
MG132, a proteasome inhibitor, enhances LDL uptake in HepG2 cells in vitro by regulating LDLR and PCSK9 expression.
A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis.
Dihydrocapsaicin Attenuates Plaque Formation through a PPARγ/LXRα Pathway in apoE(-/-) Mice Fed a High-Fat/High-Cholesterol Diet.
Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats.
Nguyen CDK, Colón-Emeric BA, Murakami S, Shujath MNY, Yi C
Cell reports 2024 May 28;43(5):114176
Cell reports 2024 May 28;43(5):114176
Betaine supplementation alleviates corticosterone-induced hepatic cholesterol accumulation through epigenetic modulation of HMGCR and CYP7A1 genes in laying hens.
Wu Y, Zhang M, Meng F, Ren K, Li D, Luo X, Hu Y
Poultry science 2024 Mar;103(3):103435
Poultry science 2024 Mar;103(3):103435
CCR9 overexpression promotes T-ALL progression by enhancing cholesterol biosynthesis.
Jamal M, Lei Y, He H, Zeng X, Bangash HI, Xiao D, Shao L, Zhou F, Zhang Q
Frontiers in pharmacology 2023;14:1257289
Frontiers in pharmacology 2023;14:1257289
miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway.
Xing K, Bian X, Shi D, Dong S, Zhou H, Xiao S, Bai J, Wu W
Journal of hepatocellular carcinoma 2023;10:2173-2185
Journal of hepatocellular carcinoma 2023;10:2173-2185
Inflammation Induced by Lipopolysaccharide and Palmitic Acid Increases Cholesterol Accumulation via Enhancing Myeloid Differentiation Factor 88 Expression in HepG2 Cells.
Chen J, Liu Y, Luo H, Chen G, Zheng Z, Wang T, Hu X, Zhao Y, Tang J, Su C, Zha L
Pharmaceuticals (Basel, Switzerland) 2022 Jun 30;15(7)
Pharmaceuticals (Basel, Switzerland) 2022 Jun 30;15(7)
Ethyl acetate extract of sappanwood alleviates experimental atherosclerosis in rats through changes in FGF21 and SREBP-2 expression.
Li Q, Wang H, Zhang C, Tong R, Chen H, Qie R
International journal of clinical and experimental pathology 2020;13(2):220-229
International journal of clinical and experimental pathology 2020;13(2):220-229
Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.
Wang D, Yang X, Chen Y, Gong K, Yu M, Gao Y, Wu X, Hu H, Liao C, Han J, Duan Y
The Journal of biological chemistry 2020 Nov 20;295(47):15870-15882
The Journal of biological chemistry 2020 Nov 20;295(47):15870-15882
Maternal betaine supplementation decreases hepatic cholesterol deposition in chicken offspring with epigenetic modulation of SREBP2 and CYP7A1 genes.
Hu Y, Feng Y, Ding Z, Lv L, Sui Y, Sun Q, Abobaker H, Cai D, Zhao R
Poultry science 2020 Jun;99(6):3111-3120
Poultry science 2020 Jun;99(6):3111-3120
Apigenin reduces the excessive accumulation of lipids induced by palmitic acid via the AMPK signaling pathway in HepG2 cells.
Lu J, Meng Z, Cheng B, Liu M, Tao S, Guan S
Experimental and therapeutic medicine 2019 Oct;18(4):2965-2971
Experimental and therapeutic medicine 2019 Oct;18(4):2965-2971
OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signalling pathway.
Zhang C, Zhang H, Zhang M, Lin C, Wang H, Yao J, Wei Q, Lu Y, Chen Z, Xing G, Cao X
Experimental cell research 2019 Oct 15;383(2):111512
Experimental cell research 2019 Oct 15;383(2):111512
Hydrogen sulfide inhibits PCSK9 expression through the PI3K/Akt‑SREBP‑2 signaling pathway to influence lipid metabolism in HepG2 cells.
Xiao J, Bai XQ, Liao L, Zhou M, Peng J, Xiang Q, Ren Z, Wen HY, Jiang ZS, Tang ZH, Wang MM, Liu LS
International journal of molecular medicine 2019 May;43(5):2055-2063
International journal of molecular medicine 2019 May;43(5):2055-2063
Lonicera caerulea Berry Polyphenols Activate SIRT1, Enhancing Inhibition of Raw264.7 Macrophage Foam Cell Formation and Promoting Cholesterol Efflux.
Liu S, Sui Q, Zhao Y, Chang X
Journal of agricultural and food chemistry 2019 Jun 26;67(25):7157-7166
Journal of agricultural and food chemistry 2019 Jun 26;67(25):7157-7166
SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target.
Yuan S, Chu H, Chan JF, Ye ZW, Wen L, Yan B, Lai PM, Tee KM, Huang J, Chen D, Li C, Zhao X, Yang D, Chiu MC, Yip C, Poon VK, Chan CC, Sze KH, Zhou J, Chan IH, Kok KH, To KK, Kao RY, Lau JY, Jin DY, Perlman S, Yuen KY
Nature communications 2019 Jan 10;10(1):120
Nature communications 2019 Jan 10;10(1):120
Prenatal exposure to diesel exhaust PM(2.5) programmed non-alcoholic fatty liver disease differently in adult male offspring of mice fed normal chow and a high-fat diet.
Wang X, Yang Y, Zhu P, Wu Y, Jin Y, Yu S, Wei H, Qian M, Cao W, Xu S, Liu Y, Chen G, Zhao X
Environmental pollution (Barking, Essex : 1987) 2019 Dec;255(Pt 1):113366
Environmental pollution (Barking, Essex : 1987) 2019 Dec;255(Pt 1):113366
Cholesterol-lowering effects and potential mechanisms of chitooligosaccharide capsules in hyperlipidemic rats.
Jiang Y, Fu C, Liu G, Guo J, Su Z
Food & nutrition research 2018;62
Food & nutrition research 2018;62
6-Gingerol Ameliorates Behavioral Changes and Atherosclerotic Lesions in ApoE(-/-) Mice Exposed to Chronic Mild Stress.
Wang S, Tian M, Yang R, Jing Y, Chen W, Wang J, Zheng X, Wang F
Cardiovascular toxicology 2018 Oct;18(5):420-430
Cardiovascular toxicology 2018 Oct;18(5):420-430
Intracellular hepatitis B virus increases hepatic cholesterol deposition in alcoholic fatty liver via hepatitis B core protein.
Wang Y, Wu T, Hu D, Weng X, Wang X, Chen PJ, Luo X, Wang H, Ning Q
Journal of lipid research 2018 Jan;59(1):58-68
Journal of lipid research 2018 Jan;59(1):58-68
Flavonoids extracted from Linaria vulgaris protect against hyperlipidemia and hepatic steatosis induced by western-type diet in mice.
Kuang W, Zhang X, Lan Z
Archives of pharmacal research 2018 Dec;41(12):1190-1198
Archives of pharmacal research 2018 Dec;41(12):1190-1198
Red algae (Gelidium amansii) hot-water extract ameliorates lipid metabolism in hamsters fed a high-fat diet.
Yang TH, Yao HT, Chiang MT
Journal of food and drug analysis 2017 Oct;25(4):931-938
Journal of food and drug analysis 2017 Oct;25(4):931-938
Prenatal betaine exposure alleviates corticosterone-induced inhibition of CYP27A1 expression in the liver of juvenile chickens associated with its promoter DNA methylation.
Hu Y, Sun Q, Zong Y, Liu J, Idriss AA, Omer NA, Zhao R
General and comparative endocrinology 2017 May 15;246:241-248
General and comparative endocrinology 2017 May 15;246:241-248
Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.
He K, Hu Y, Ma H, Zou Z, Xiao Y, Yang Y, Feng M, Li X, Ye X
Biochimica et biophysica acta 2016 Sep;1862(9):1696-709
Biochimica et biophysica acta 2016 Sep;1862(9):1696-709
TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis.
Hsieh J, Koseki M, Molusky MM, Yakushiji E, Ichi I, Westerterp M, Iqbal J, Chan RB, Abramowicz S, Tascau L, Takiguchi S, Yamashita S, Welch CL, Di Paolo G, Hussain MM, Lefkowitch JH, Rader DJ, Tall AR
Nature 2016 Jul 14;535(7611):303-7
Nature 2016 Jul 14;535(7611):303-7
VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.
Hu YW, Wu SG, Zhao JJ, Ma X, Lu JB, Xiu JC, Zhang Y, Huang C, Qiu YR, Sha YH, Gao JJ, Wang YC, Li SF, Zhao JY, Zheng L, Wang Q
Journal of lipid research 2016 Aug;57(8):1398-411
Journal of lipid research 2016 Aug;57(8):1398-411
Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice.
He K, Li X, Xiao Y, Yong Y, Zhang Z, Li S, Zhou T, Yang D, Gao P, Xin X
Food & function 2016 Aug 10;7(8):3505-15
Food & function 2016 Aug 10;7(8):3505-15
RP5-833A20.1/miR-382-5p/NFIA-dependent signal transduction pathway contributes to the regulation of cholesterol homeostasis and inflammatory reaction.
Hu YW, Zhao JY, Li SF, Huang JL, Qiu YR, Ma X, Wu SG, Chen ZP, Hu YR, Yang JY, Wang YC, Gao JJ, Sha YH, Zheng L, Wang Q
Arteriosclerosis, thrombosis, and vascular biology 2015 Jan;35(1):87-101
Arteriosclerosis, thrombosis, and vascular biology 2015 Jan;35(1):87-101
Potent effects of dioscin against obesity in mice.
Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973
Scientific reports 2015 Jan 22;5:7973
The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters.
He K, Ye X, Wu H, Wang Y, Zou Z, Ning N, Hu Y, Chen B, Fang X, Li X
Lipids 2015 Feb;50(2):185-94
Lipids 2015 Feb;50(2):185-94
The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1.
Han J, Li E, Chen L, Zhang Y, Wei F, Liu J, Deng H, Wang Y
Nature 2015 Aug 13;524(7564):243-6
Nature 2015 Aug 13;524(7564):243-6
Protective effects of dioscin against alcohol-induced liver injury.
Xu T, Zheng L, Xu L, Yin L, Qi Y, Xu Y, Han X, Peng J
Archives of toxicology 2014 Mar;88(3):739-53
Archives of toxicology 2014 Mar;88(3):739-53
The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis.
Fryer LG, Jones B, Duncan EJ, Hutchison CE, Ozkan T, Williams PA, Alder O, Nieuwdorp M, Townley AK, Mensenkamp AR, Stephens DJ, Dallinga-Thie GM, Shoulders CC
The Journal of biological chemistry 2014 Feb 14;289(7):4244-61
The Journal of biological chemistry 2014 Feb 14;289(7):4244-61
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2014 Dec;5(12):3065-3075
Food & function 2014 Dec;5(12):3065-3075
MG132, a proteasome inhibitor, enhances LDL uptake in HepG2 cells in vitro by regulating LDLR and PCSK9 expression.
Yan H, Ma YL, Gui YZ, Wang SM, Wang XB, Gao F, Wang YP
Acta pharmacologica Sinica 2014 Aug;35(8):994-1004
Acta pharmacologica Sinica 2014 Aug;35(8):994-1004
A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis.
Hu YW, Yang JY, Ma X, Chen ZP, Hu YR, Zhao JY, Li SF, Qiu YR, Lu JB, Wang YC, Gao JJ, Sha YH, Zheng L, Wang Q
Journal of lipid research 2014 Apr;55(4):681-97
Journal of lipid research 2014 Apr;55(4):681-97
Dihydrocapsaicin Attenuates Plaque Formation through a PPARγ/LXRα Pathway in apoE(-/-) Mice Fed a High-Fat/High-Cholesterol Diet.
Hu YW, Ma X, Huang JL, Mao XR, Yang JY, Zhao JY, Li SF, Qiu YR, Yang J, Zheng L, Wang Q
PloS one 2013;8(6):e66876
PloS one 2013;8(6):e66876
Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats.
Zhang S, Zheng L, Dong D, Xu L, Yin L, Qi Y, Han X, Lin Y, Liu K, Peng J
Food chemistry 2013 Dec 1;141(3):2108-16
Food chemistry 2013 Dec 1;141(3):2108-16
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 14508-1-AP(SREBF2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 14508-1-AP(SREBF2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SREBF2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SREBF2. This antibody recognizes human,mouse,rat antigen. The SREBF2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.