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- References [5]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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- Product number
- ABIN954950 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (Center) antibody
- Antibody type
- Polyclonal
- Antigen
- Other
- Reactivity
- Human
- Host
- Rabbit
- Vial size
- 0.1 mg
Submitted references Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation.
HNF1alpha and SREBP2 are important regulators of NPC1L1 in human liver.
MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis.
miR-33 links SREBP-2 induction to repression of sterol transporters.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes care 2010 Oct;33(10):2250-3
Diabetes care 2010 Oct;33(10):2250-3
Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation.
Gerin I, Clerbaux LA, Haumont O, Lanthier N, Das AK, Burant CF, Leclercq IA, MacDougald OA, Bommer GT
The Journal of biological chemistry 2010 Oct 29;285(44):33652-61
The Journal of biological chemistry 2010 Oct 29;285(44):33652-61
HNF1alpha and SREBP2 are important regulators of NPC1L1 in human liver.
Pramfalk C, Jiang ZY, Cai Q, Hu H, Zhang SD, Han TQ, Eriksson M, Parini P
Journal of lipid research 2010 Jun;51(6):1354-62
Journal of lipid research 2010 Jun;51(6):1354-62
MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis.
Najafi-Shoushtari SH, Kristo F, Li Y, Shioda T, Cohen DE, Gerszten RE, Näär AM
Science (New York, N.Y.) 2010 Jun 18;328(5985):1566-9
Science (New York, N.Y.) 2010 Jun 18;328(5985):1566-9
miR-33 links SREBP-2 induction to repression of sterol transporters.
Marquart TJ, Allen RM, Ory DS, Baldán A
Proceedings of the National Academy of Sciences of the United States of America 2010 Jul 6;107(27):12228-32
Proceedings of the National Academy of Sciences of the United States of America 2010 Jul 6;107(27):12228-32
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Western blot analysis in HepG2 cell line lysates (35ug/lane) using SREBF2 / SREBP2 antibody Cat.-No. AP54043PU-N. This demonstrates the SREBF2 antibody detected the SREBF2 protein (arrow).
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Confocal immunofluorescent analysis with HepG2 cells using SREBF2 / SREBP2 antibody Cat.-No. AP54043PU-N, followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Immunohistochemistry analysis in human skin carcinoma, followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SREBF2 antibody for IHC; Clinical relevance has not been evaluated.
