BS7794

antibody from Bioworld Technology, Inc
Targeting: CPB2 CPU, PCPB, TAFI
Provider product page for BS7794
Western blot
Immunohistochemistry

Antibody data

Product number
BS7794 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CPB2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human CPB2.
Description
The Thrombin-activatable fibrinolysis inhibitor (TAFI), also designated procarboxypeptidase B2 or procarboxypeptidase U, is a hepatically secreted zymogen that downregulates fibrinolysis when activated by Thrombin. It is synthesized in the liver and circulates in plasma in its proenzyme form. When activated, TAFI removes C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins. TAFI cleaves the lysine residues from Fibrin, which prevents plasminogen from activation into plasmin and retards the lysis of a Fibrin clot. Elevated concentration of TAFI in blood is considered a risk factor for venous thrombosis, whereas a deficiency might contribute to the severity of bleeding disorders in hemophilias A and B. Decreased levels of TAFI are found in chronic liver disease.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CPB2 protein structure - BS7794 shown in red.