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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
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- Western blot [1]
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- Product number
- BS4841 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- HNF4Ï« (phospho S313) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic phosphopeptide derived from human HNF4Ï« around the phosphorylation site of Serine 313.
- Description
- Hepatocyte nuclear factor 4Ï« (HNF4Ï«) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver. HNF4Ï«, in association with PGC-1Ï«, activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers. Conditional knockout of the HNF4Ï« gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels. Mutations in HNF4Ï« have been linked to maturity-onset diabetes of the young (MODY).
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of p-HNF4-¦Á (S313) pAb at 1:500 dilutionLane1:Hela cell lysate treated with EGF(0.1ng/ml,30mins)Lane2:Raw264.7 cell lysate treated with EGF(0.1ng/ml,30mins)Lane3:PC12 cell lysate treated with EGF(0.1ng/ml,30mins)
