CABT-B085

antibody from Creative Diagnostics

Targeting: NR3C1 GR, GRL

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

CABT-B085

Provider

Creative Diagnostics

Product name

Anti-Glucocorticoid Receptor monoclonal antibody, clone GJHS

Antibody type

Monoclonal

Description

The glucocorticoid receptor (GR) is a ubiquitous ligand dependent transcription factor important in cellular and organism hemostasis. It exists in the cytoplasm of virtually all cells in a complex with a number of heat shock, chaperone and immunophilin proteins (1). Upon binding glucocorticoids such as cortisol (endogenous, human) or dexamethasone (one of many synthetics) the complex is altered through component exchange and migrates into the nucleus where the receptor binds to specific DNA response elements (GRE). Depending on the promoter and co-regulatory molecules present, gene expression can be either induced or repressed (2). In addition the GR can interact with other transcription factors such as NFkB and AP1 to interfere with other signaling pathways. Glucocorticoids are used clinically to modulate diseases or unwanted reactions of the immune system.

Reactivity

Mouse, Rat, Hamster

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

GJHS

Vial size

100_g

Concentration

0.5 mg/mL

Storage

-20°C