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antibody from Novus Biologicals
Targeting: CXCL2
CINC-2a, GRO2, GROb, MGSA-b, MIP-2a, SCYB2
Immunocytochemistry
Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
- References [18]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
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- Product number
- AF-452-NA - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal CXCL2/GRO beta/MIP-2/CINC-3 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse CXCL2/MIP-2 in direct ELISAs and Western blots. In direct ELISAs, less than 10% cross-reactivity with recombinant human (rh) GRO beta , recombinant mouse (rm) GRO gamma , rmKC and rmLIX is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice.
Mannan-binding lectin deficiency exacerbates sterile liver injury in mice through enhancing hepatic neutrophil recruitment.
An IFNγ/CXCL2 regulatory pathway determines lesion localization during EAE.
Novel adherent CD11b+ Gr-1+ tumor-infiltrating cells initiate an immunosuppressive tumor microenvironment.
Mycobacterium tuberculosis-triggered Hippo pathway orchestrates CXCL1/2 expression to modulate host immune responses.
TIARP attenuates autoantibody-mediated arthritis via the suppression of neutrophil migration by reducing CXCL2/CXCR2 and IL-6 expression.
Sphingolipid pathway regulates innate immune responses at the fetomaternal interface during pregnancy.
The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis.
Type I IFN suppresses Cxcr2 driven neutrophil recruitment into the sensory ganglia during viral infection.
CXCR2-mediated tumor-associated neutrophil recruitment is regulated by IFN-β.
Neutrophil dependence of vascular remodeling after Mycoplasma infection of mouse airways.
Comprehensive assessment of chemokine expression profiles by flow cytometry.
Initial delay in the immune response to Francisella tularensis is followed by hypercytokinemia characteristic of severe sepsis and correlating with upregulation and release of damage-associated molecular patterns.
The Duffy antigen receptor for chemokines in acute renal failure: A facilitator of renal chemokine presentation.
The Duffy antigen receptor for chemokines in acute renal failure: A facilitator of renal chemokine presentation.
CC chemokines mediate leukocyte trafficking into the central nervous system during murine neurocysticercosis: role of gamma delta T cells in amplification of the host immune response.
CC chemokines mediate leukocyte trafficking into the central nervous system during murine neurocysticercosis: role of gamma delta T cells in amplification of the host immune response.
The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium.
Nakajima K, Ono M, Radović U, Dizdarević S, Tomizawa SI, Kuroha K, Nagamatsu G, Hoshi I, Matsunaga R, Shirakawa T, Kurosawa T, Miyazaki Y, Seki M, Suzuki Y, Koseki H, Nakamura M, Suda T, Ohbo K
Disease models & mechanisms 2019 Nov 12;12(11)
Disease models & mechanisms 2019 Nov 12;12(11)
Mannan-binding lectin deficiency exacerbates sterile liver injury in mice through enhancing hepatic neutrophil recruitment.
Zhou J, Li J, Yu Y, Liu Y, Li H, Liu Y, Wang J, Zhang L, Lu X, Chen Z, Zuo D
Journal of leukocyte biology 2019 Jan;105(1):177-186
Journal of leukocyte biology 2019 Jan;105(1):177-186
An IFNγ/CXCL2 regulatory pathway determines lesion localization during EAE.
Stoolman JS, Duncker PC, Huber AK, Giles DA, Washnock-Schmid JM, Soulika AM, Segal BM
Journal of neuroinflammation 2018 Jul 16;15(1):208
Journal of neuroinflammation 2018 Jul 16;15(1):208
Novel adherent CD11b+ Gr-1+ tumor-infiltrating cells initiate an immunosuppressive tumor microenvironment.
Tsubaki T, Kadonosono T, Sakurai S, Shiozawa T, Goto T, Sakai S, Kuchimaru T, Sakamoto T, Watanabe H, Kondoh G, Kizaka-Kondoh S
Oncotarget 2018 Feb 16;9(13):11209-11226
Oncotarget 2018 Feb 16;9(13):11209-11226
Mycobacterium tuberculosis-triggered Hippo pathway orchestrates CXCL1/2 expression to modulate host immune responses.
Boro M, Singh V, Balaji KN
Scientific reports 2016 Nov 24;6:37695
Scientific reports 2016 Nov 24;6:37695
TIARP attenuates autoantibody-mediated arthritis via the suppression of neutrophil migration by reducing CXCL2/CXCR2 and IL-6 expression.
Inoue A, Matsumoto I, Tanaka Y, Umeda N, Takai C, Kawaguchi H, Ebe H, Yoshida H, Matsumoto Y, Segawa S, Takahashi S, Sumida T
Scientific reports 2016 Dec 20;6:38684
Scientific reports 2016 Dec 20;6:38684
Sphingolipid pathway regulates innate immune responses at the fetomaternal interface during pregnancy.
Mizugishi K, Inoue T, Hatayama H, Bielawski J, Pierce JS, Sato Y, Takaori-Kondo A, Konishi I, Yamashita K
The Journal of biological chemistry 2015 Jan 23;290(4):2053-68
The Journal of biological chemistry 2015 Jan 23;290(4):2053-68
The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis.
Huebener P, Pradere JP, Hernandez C, Gwak GY, Caviglia JM, Mu X, Loike JD, Schwabe RF
The Journal of clinical investigation 2015 Feb;125(2):539-50
The Journal of clinical investigation 2015 Feb;125(2):539-50
Type I IFN suppresses Cxcr2 driven neutrophil recruitment into the sensory ganglia during viral infection.
Stock AT, Smith JM, Carbone FR
The Journal of experimental medicine 2014 May 5;211(5):751-9
The Journal of experimental medicine 2014 May 5;211(5):751-9
CXCR2-mediated tumor-associated neutrophil recruitment is regulated by IFN-β.
Jablonska J, Wu CF, Andzinski L, Leschner S, Weiss S
International journal of cancer 2014 Mar 15;134(6):1346-58
International journal of cancer 2014 Mar 15;134(6):1346-58
Neutrophil dependence of vascular remodeling after Mycoplasma infection of mouse airways.
Baluk P, Phillips K, Yao LC, Adams A, Nitschké M, McDonald DM
The American journal of pathology 2014 Jun;184(6):1877-89
The American journal of pathology 2014 Jun;184(6):1877-89
Comprehensive assessment of chemokine expression profiles by flow cytometry.
Eberlein J, Nguyen TT, Victorino F, Golden-Mason L, Rosen HR, Homann D
The Journal of clinical investigation 2010 Mar;120(3):907-23
The Journal of clinical investigation 2010 Mar;120(3):907-23
Initial delay in the immune response to Francisella tularensis is followed by hypercytokinemia characteristic of severe sepsis and correlating with upregulation and release of damage-associated molecular patterns.
Mares CA, Ojeda SS, Morris EG, Li Q, Teale JM
Infection and immunity 2008 Jul;76(7):3001-10
Infection and immunity 2008 Jul;76(7):3001-10
The Duffy antigen receptor for chemokines in acute renal failure: A facilitator of renal chemokine presentation.
Zarbock A, Schmolke M, Bockhorn SG, Scharte M, Buschmann K, Ley K, Singbartl K
Critical care medicine 2007 Sep;35(9):2156-63
Critical care medicine 2007 Sep;35(9):2156-63
The Duffy antigen receptor for chemokines in acute renal failure: A facilitator of renal chemokine presentation.
Zarbock A, Schmolke M, Bockhorn SG, Scharte M, Buschmann K, Ley K, Singbartl K
Critical care medicine 2007 Sep;35(9):2156-63
Critical care medicine 2007 Sep;35(9):2156-63
CC chemokines mediate leukocyte trafficking into the central nervous system during murine neurocysticercosis: role of gamma delta T cells in amplification of the host immune response.
Cardona AE, Gonzalez PA, Teale JM
Infection and immunity 2003 May;71(5):2634-42
Infection and immunity 2003 May;71(5):2634-42
CC chemokines mediate leukocyte trafficking into the central nervous system during murine neurocysticercosis: role of gamma delta T cells in amplification of the host immune response.
Cardona AE, Gonzalez PA, Teale JM
Infection and immunity 2003 May;71(5):2634-42
Infection and immunity 2003 May;71(5):2634-42
The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium.
Huo Y, Weber C, Forlow SB, Sperandio M, Thatte J, Mack M, Jung S, Littman DR, Ley K
The Journal of clinical investigation 2001 Nov;108(9):1307-14
The Journal of clinical investigation 2001 Nov;108(9):1307-14
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Chemotaxis Induced by CXCL2/MIP-2 and Neutral-ization by Mouse CXCL2/ MIP-2 Antibody. Chemotaxis Induced by CXCL2/MIP-2 and Neutral-ization by Mouse CXCL2/ MIP-2 Antibody.
