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- Antigen structure
- References [12]
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- Western blot [2]
- Immunohistochemistry [1]
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- Product number
- ABIN268863 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) (AA 1000-1100), (Internal Region) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Rabbit
- Epitope
- Internal Region, AA 1000-1100
- Vial size
- 0.025 mL
- Storage
- Store at 4°C. Do not freeze.
- Handling
- Do not freeze.
Submitted references Hypocholesterolemic Activity of Curcumin Is Mediated by Down-regulating the Expression of Niemann-Pick C1-like 1 in Hamsters.
Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism.
Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression.
Oligodendroglial process formation is differentially affected by modulating the intra- and extracellular cholesterol content.
Unsaturated fatty acids and phytosterols regulate cholesterol transporter genes in Caco-2 and HepG2 cell lines.
Modulatory role of PYY in transport and metabolism of cholesterol in intestinal epithelial cells.
Dietary cholesterol induces trafficking of intestinal Niemann-Pick Type C1 Like 1 from the brush border to endosomes.
Polyunsaturated fatty acids down-regulate in vitro expression of the key intestinal cholesterol absorption protein NPC1L1: no effect of monounsaturated nor saturated fatty acids.
Inhibition of hepatic Niemann-Pick C1-like 1 improves hepatic insulin resistance.
Niemann-Pick C1 functions in regulating lysosomal amine content.
Intestinal fatty acid binding protein regulates mitochondrion beta-oxidation and cholesterol uptake.
Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane.
Feng D, Zou J, Zhang S, Li X, Lu M
Journal of agricultural and food chemistry 2017 Jan 18;65(2):276-280
Journal of agricultural and food chemistry 2017 Jan 18;65(2):276-280
Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism.
Sachdev V, Leopold C, Bauer R, Patankar JV, Iqbal J, Obrowsky S, Boverhof R, Doktorova M, Scheicher B, Goeritzer M, Kolb D, Turnbull AV, Zimmer A, Hoefler G, Hussain MM, Groen AK, Kratky D
Biochimica et biophysica acta 2016 Sep;1861(9 Pt A):1132-1141
Biochimica et biophysica acta 2016 Sep;1861(9 Pt A):1132-1141
Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression.
Kikuchi T, Orihara K, Oikawa F, Han SI, Kuba M, Okuda K, Satoh A, Osaki Y, Takeuchi Y, Aita Y, Matsuzaka T, Iwasaki H, Yatoh S, Sekiya M, Yahagi N, Suzuki H, Sone H, Nakagawa Y, Yamada N, Shimano H
Molecular metabolism 2016 Nov;5(11):1092-1102
Molecular metabolism 2016 Nov;5(11):1092-1102
Oligodendroglial process formation is differentially affected by modulating the intra- and extracellular cholesterol content.
Schmitz M, Signore SC, Zerr I, Althaus HH
Journal of molecular neuroscience : MN 2013 Mar;49(3):457-69
Journal of molecular neuroscience : MN 2013 Mar;49(3):457-69
Unsaturated fatty acids and phytosterols regulate cholesterol transporter genes in Caco-2 and HepG2 cell lines.
Park Y, Carr TP
Nutrition research (New York, N.Y.) 2013 Feb;33(2):154-61
Nutrition research (New York, N.Y.) 2013 Feb;33(2):154-61
Modulatory role of PYY in transport and metabolism of cholesterol in intestinal epithelial cells.
Grenier E, Garofalo C, Delvin E, Levy E
PloS one 2012;7(7):e40992
PloS one 2012;7(7):e40992
Dietary cholesterol induces trafficking of intestinal Niemann-Pick Type C1 Like 1 from the brush border to endosomes.
Skov M, Tønnesen CK, Hansen GH, Danielsen EM
American journal of physiology. Gastrointestinal and liver physiology 2011 Jan;300(1):G33-40
American journal of physiology. Gastrointestinal and liver physiology 2011 Jan;300(1):G33-40
Polyunsaturated fatty acids down-regulate in vitro expression of the key intestinal cholesterol absorption protein NPC1L1: no effect of monounsaturated nor saturated fatty acids.
Alvaro A, Rosales R, Masana L, Vallvé JC
The Journal of nutritional biochemistry 2010 Jun;21(6):518-25
The Journal of nutritional biochemistry 2010 Jun;21(6):518-25
Inhibition of hepatic Niemann-Pick C1-like 1 improves hepatic insulin resistance.
Nomura M, Ishii H, Kawakami A, Yoshida M
American journal of physiology. Endocrinology and metabolism 2009 Nov;297(5):E1030-8
American journal of physiology. Endocrinology and metabolism 2009 Nov;297(5):E1030-8
Niemann-Pick C1 functions in regulating lysosomal amine content.
Kaufmann AM, Krise JP
The Journal of biological chemistry 2008 Sep 5;283(36):24584-93
The Journal of biological chemistry 2008 Sep 5;283(36):24584-93
Intestinal fatty acid binding protein regulates mitochondrion beta-oxidation and cholesterol uptake.
Montoudis A, Seidman E, Boudreau F, Beaulieu JF, Menard D, Elchebly M, Mailhot G, Sane AT, Lambert M, Delvin E, Levy E
Journal of lipid research 2008 May;49(5):961-72
Journal of lipid research 2008 May;49(5):961-72
Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane.
Knöpfel M, Davies JP, Duong PT, Kvaernø L, Carreira EM, Phillips MC, Ioannou YA, Hauser H
Biochimica et biophysica acta 2007 Sep;1771(9):1140-7
Biochimica et biophysica acta 2007 Sep;1771(9):1140-7
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Supportive validation
- Submitted by
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