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- Antibody Data
- Antigen structure
- References [16]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- ABIN152897 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) (AA 500-600), (Internal Region) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- Internal Region, AA 500-600
- Vial size
- 0.1 mL
- Storage
- Store at 4°C. Do not freeze.
- Handling
- Do not freeze.
Submitted references Exposure to dietary lipid leads to rapid production of cytosolic lipid droplets near the brush border membrane.
Pravastatin Modulate Niemann-Pick C1-Like 1 and ATP-Binding Cassette G5 and G8 to Influence Intestinal Cholesterol Absorption.
New Insights In Intestinal Sar1B GTPase Regulation and Role in Cholesterol Homeostasis.
Intestinal pregnane X receptor links xenobiotic exposure and hypercholesterolemia.
NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy.
Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease.
D-Glucose modulates intestinal Niemann-Pick C1-like 1 (NPC1L1) gene expression via transcriptional regulation.
Reduction in cholesterol absorption in Caco-2 cells through the down-regulation of Niemann-Pick C1-like 1 by the putative probiotic strains Lactobacillus rhamnosus BFE5264 and Lactobacillus plantarum NR74 from fermented foods.
EP 80317, a CD36 selective ligand, promotes reverse cholesterol transport in apolipoprotein E-deficient mice.
Black pepper and piperine reduce cholesterol uptake and enhance translocation of cholesterol transporter proteins.
PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells.
Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice.
Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance.
Intestinal fatty acid binding protein regulates mitochondrion beta-oxidation and cholesterol uptake.
Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein.
CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine.
Soayfane Z, Tercé F, Cantiello M, Robenek H, Nauze M, Bézirard V, Allart S, Payré B, Capilla F, Cartier C, Peres C, Al Saati T, Théodorou V, Nelson DW, Yen CE, Collet X, Coméra C
Nutrition & metabolism 2016;13:48
Nutrition & metabolism 2016;13:48
Pravastatin Modulate Niemann-Pick C1-Like 1 and ATP-Binding Cassette G5 and G8 to Influence Intestinal Cholesterol Absorption.
Kawase A, Hata S, Takagi M, Iwaki M
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2015;18(5):765-72
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2015;18(5):765-72
New Insights In Intestinal Sar1B GTPase Regulation and Role in Cholesterol Homeostasis.
Sané A, Seidman E, Spahis S, Lamantia V, Garofalo C, Montoudis A, Marcil V, Levy E
Journal of cellular biochemistry 2015 Oct;116(10):2270-82
Journal of cellular biochemistry 2015 Oct;116(10):2270-82
Intestinal pregnane X receptor links xenobiotic exposure and hypercholesterolemia.
Sui Y, Helsley RN, Park SH, Song X, Liu Z, Zhou C
Molecular endocrinology (Baltimore, Md.) 2015 May;29(5):765-76
Molecular endocrinology (Baltimore, Md.) 2015 May;29(5):765-76
NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy.
Takada T, Yamanashi Y, Konishi K, Yamamoto T, Toyoda Y, Masuo Y, Yamamoto H, Suzuki H
Science translational medicine 2015 Feb 18;7(275):275ra23
Science translational medicine 2015 Feb 18;7(275):275ra23
Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease.
Ahn SB, Jang K, Jun DW, Lee BH, Shin KJ
Digestive diseases and sciences 2014 Dec;59(12):2975-82
Digestive diseases and sciences 2014 Dec;59(12):2975-82
D-Glucose modulates intestinal Niemann-Pick C1-like 1 (NPC1L1) gene expression via transcriptional regulation.
Malhotra P, Boddy CS, Soni V, Saksena S, Dudeja PK, Gill RK, Alrefai WA
American journal of physiology. Gastrointestinal and liver physiology 2013 Jan 15;304(2):G203-10
American journal of physiology. Gastrointestinal and liver physiology 2013 Jan 15;304(2):G203-10
Reduction in cholesterol absorption in Caco-2 cells through the down-regulation of Niemann-Pick C1-like 1 by the putative probiotic strains Lactobacillus rhamnosus BFE5264 and Lactobacillus plantarum NR74 from fermented foods.
Yoon HS, Ju JH, Kim HN, Park HJ, Ji Y, Lee JE, Shin HK, Do MS, Holzapfel W
International journal of food sciences and nutrition 2013 Feb;64(1):44-52
International journal of food sciences and nutrition 2013 Feb;64(1):44-52
EP 80317, a CD36 selective ligand, promotes reverse cholesterol transport in apolipoprotein E-deficient mice.
Bujold K, Mellal K, Zoccal KF, Rhainds D, Brissette L, Febbraio M, Marleau S, Ong H
Atherosclerosis 2013 Aug;229(2):408-14
Atherosclerosis 2013 Aug;229(2):408-14
Black pepper and piperine reduce cholesterol uptake and enhance translocation of cholesterol transporter proteins.
Duangjai A, Ingkaninan K, Praputbut S, Limpeanchob N
Journal of natural medicines 2013 Apr;67(2):303-10
Journal of natural medicines 2013 Apr;67(2):303-10
PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells.
Levy E, Ben Djoudi Ouadda A, Spahis S, Sane AT, Garofalo C, Grenier É, Emonnot L, Yara S, Couture P, Beaulieu JF, Ménard D, Seidah NG, Elchebly M
Atherosclerosis 2013 Apr;227(2):297-306
Atherosclerosis 2013 Apr;227(2):297-306
Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice.
Hager L, Li L, Pun H, Liu L, Hossain MA, Maguire GF, Naples M, Baker C, Magomedova L, Tam J, Adeli K, Cummins CL, Connelly PW, Ng DS
The Journal of biological chemistry 2012 Jun 8;287(24):20755-68
The Journal of biological chemistry 2012 Jun 8;287(24):20755-68
Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance.
Liu W, Mani S, Davis NR, Sarrafzadegan N, Kavathas PB, Mani A
Circulation research 2008 Nov 21;103(11):1280-8
Circulation research 2008 Nov 21;103(11):1280-8
Intestinal fatty acid binding protein regulates mitochondrion beta-oxidation and cholesterol uptake.
Montoudis A, Seidman E, Boudreau F, Beaulieu JF, Menard D, Elchebly M, Mailhot G, Sane AT, Lambert M, Delvin E, Levy E
Journal of lipid research 2008 May;49(5):961-72
Journal of lipid research 2008 May;49(5):961-72
Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein.
Infante RE, Abi-Mosleh L, Radhakrishnan A, Dale JD, Brown MS, Goldstein JL
The Journal of biological chemistry 2008 Jan 11;283(2):1052-63
The Journal of biological chemistry 2008 Jan 11;283(2):1052-63
CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine.
Nassir F, Wilson B, Han X, Gross RW, Abumrad NA
The Journal of biological chemistry 2007 Jul 6;282(27):19493-501
The Journal of biological chemistry 2007 Jul 6;282(27):19493-501
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
