NB400-127

Nihei W, Nagafuku M, Hayamizu H, Odagiri Y, Tamura Y, Kikuchi Y, Veillon L, Kanoh H, Inamori KI, Arai K, Kabayama K, Fukase K, Inokuchi JI
Journal of lipid research 2018 Nov;59(11):2181-2187

Hypocholesterolemic Activity of Curcumin Is Mediated by Down-regulating the Expression of Niemann-Pick C1-like 1 in Hamsters.

Feng D, Zou J, Zhang S, Li X, Lu M
Journal of agricultural and food chemistry 2017 Jan 18;65(2):276-280

Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism.

Sachdev V, Leopold C, Bauer R, Patankar JV, Iqbal J, Obrowsky S, Boverhof R, Doktorova M, Scheicher B, Goeritzer M, Kolb D, Turnbull AV, Zimmer A, Hoefler G, Hussain MM, Groen AK, Kratky D
Biochimica et biophysica acta 2016 Sep;1861(9 Pt A):1132-1141

Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression.

Kikuchi T, Orihara K, Oikawa F, Han SI, Kuba M, Okuda K, Satoh A, Osaki Y, Takeuchi Y, Aita Y, Matsuzaka T, Iwasaki H, Yatoh S, Sekiya M, Yahagi N, Suzuki H, Sone H, Nakagawa Y, Yamada N, Shimano H
Molecular metabolism 2016 Nov;5(11):1092-1102

Oligodendroglial process formation is differentially affected by modulating the intra- and extracellular cholesterol content.

Schmitz M, Signore SC, Zerr I, Althaus HH
Journal of molecular neuroscience : MN 2013 Mar;49(3):457-69

Unsaturated fatty acids and phytosterols regulate cholesterol transporter genes in Caco-2 and HepG2 cell lines.

Park Y, Carr TP
Nutrition research (New York, N.Y.) 2013 Feb;33(2):154-61

Modulatory role of PYY in transport and metabolism of cholesterol in intestinal epithelial cells.

Grenier E, Garofalo C, Delvin E, Levy E
PloS one 2012;7(7):e40992

Dietary cholesterol induces trafficking of intestinal Niemann-Pick Type C1 Like 1 from the brush border to endosomes.

Skov M, Tønnesen CK, Hansen GH, Danielsen EM
American journal of physiology. Gastrointestinal and liver physiology 2011 Jan;300(1):G33-40

Polyunsaturated fatty acids down-regulate in vitro expression of the key intestinal cholesterol absorption protein NPC1L1: no effect of monounsaturated nor saturated fatty acids.

Alvaro A, Rosales R, Masana L, Vallvé JC
The Journal of nutritional biochemistry 2010 Jun;21(6):518-25

Inhibition of hepatic Niemann-Pick C1-like 1 improves hepatic insulin resistance.

Nomura M, Ishii H, Kawakami A, Yoshida M
American journal of physiology. Endocrinology and metabolism 2009 Nov;297(5):E1030-8

Niemann-Pick C1 functions in regulating lysosomal amine content.

Kaufmann AM, Krise JP
The Journal of biological chemistry 2008 Sep 5;283(36):24584-93

Intestinal fatty acid binding protein regulates mitochondrion beta-oxidation and cholesterol uptake.

Montoudis A, Seidman E, Boudreau F, Beaulieu JF, Menard D, Elchebly M, Mailhot G, Sane AT, Lambert M, Delvin E, Levy E
Journal of lipid research 2008 May;49(5):961-72

Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane.

Knöpfel M, Davies JP, Duong PT, Kvaernø L, Carreira EM, Phillips MC, Ioannou YA, Hauser H
Biochimica et biophysica acta 2007 Sep;1771(9):1140-7

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Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: Niemann-Pick type C1 Like-1 Antibody [NB400-127] - Detection of NPC1L1 protein in lysate of human small intestine tissue using Niemann-Pick type C1 Like-1 antibody at 2ug/ml concentration.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Immunohistochemistry: Niemann-Pick type C1 Like-1 Antibody [NB400-127] - Staining of Niemann-Pick type C1 Like-1 in mouse intestine using NB400-127.