BS1617

antibody from Bioworld Technology, Inc

Targeting: CD4

Immunocytochemistry

Immunohistochemistry

Antibody data

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Validation data

Product number: BS1617 - Provider product page
Provider: Bioworld Technology, Inc
Proper citation: Bioworld Technology Cat#BS1617, RRID:AB_1663541
Product name: CD4 (A429) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic peptide, corresponding to amino acids 391-440 of Human CD4.
Description: Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the AntigenÃ¿Major Histocompatibility Complex (MHC). Specifically, the D1 domain of CD4 interacts with the ÉÇ2-domain of the MHC class II molecule. CD4 ensures specificity of the TCRÃ¿antigen interaction, prolongs the contact between the T cell and the antigen presenting cell and recruits the tyrosine kinase Lck, which is essential for T cell activation.
Reactivity: Human, Mouse
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

CD4 protein structure - BS1617 shown in red.