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- References [21]
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- Product number
- V3289 - Provider product page
- Provider
- NSJ Bioreagents
- Product name
- Desmoglein 2 Antibody / DSG2
- Antibody type
- Monoclonal
- Description
- Purified
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antibody clone number
- 6D8
- Vial size
- 20 µg, 100 µg (with BSA, sodium azide), 100 µg (without BSA, sodium azide), 7 ml (prediluted for IHC)
- Concentration
- 0.2 mg/ml
- Storage
- Store the Desmoglein 2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Submitted references Desmoglein 2 promotes vasculogenic mimicry in melanoma and is associated with poor clinical outcome.
Epithelial Junction Opener Improves Oncolytic Adenovirus Therapy in Mouse Tumor Models.
Intracellular Signaling and Desmoglein 2 Shedding Triggered by Human Adenoviruses Ad3, Ad14, and Ad14P1.
Desmoglein 2 depletion leads to increased migration and upregulation of the chemoattractant secretoneurin in melanoma cells.
Structural and functional studies on the interaction of adenovirus fiber knobs and desmoglein 2.
Pseudotyping the adenovirus serotype 5 capsid with both the fibre and penton of serotype 35 enhances vascular smooth muscle cell transduction.
Assessment of desmosomal components (desmoglein 1-3, plakoglobin) in cardia mucosa in relation to gastroesophageal reflux disease and Helicobacter pylori infection.
Epithelial junction opener JO-1 improves monoclonal antibody therapy of cancer.
Multimerization of adenovirus serotype 3 fiber knob domains is required for efficient binding of virus to desmoglein 2 and subsequent opening of epithelial junctions.
Characterization of full-length and proteolytic cleavage fragments of desmoglein-2 in native human colon and colonic epithelial cell lines.
Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14.
Desmosome dynamics in migrating epithelial cells requires the actin cytoskeleton.
Plakophilin 2 couples actomyosin remodeling to desmosomal plaque assembly via RhoA.
A missense variant in desmoglein-2 predisposes to dilated cardiomyopathy.
Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly.
Carboxyl terminus of Plakophilin-1 recruits it to plasma membrane, whereas amino terminus recruits desmoplakin and promotes desmosome assembly.
Delineation of diversified desmoglein distribution in stratified squamous epithelia: implications in diseases.
Mispolarization of desmosomal proteins and altered intercellular adhesion in autosomal dominant polycystic kidney disease.
Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells.
Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.
Intermediate filament-membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength.
Tan LY, Mintoff C, Johan MZ, Ebert BW, Fedele C, Zhang YF, Szeto P, Sheppard KE, McArthur GA, Foster-Smith E, Ruszkiewicz A, Brown MP, Bonder CS, Shackleton M, Ebert LM
Oncotarget 2016 Jul 19;7(29):46492-46508
Oncotarget 2016 Jul 19;7(29):46492-46508
Epithelial Junction Opener Improves Oncolytic Adenovirus Therapy in Mouse Tumor Models.
Yumul R, Richter M, Lu ZZ, Saydaminova K, Wang H, Wang CH, Carter D, Lieber A
Human gene therapy 2016 Apr;27(4):325-37
Human gene therapy 2016 Apr;27(4):325-37
Intracellular Signaling and Desmoglein 2 Shedding Triggered by Human Adenoviruses Ad3, Ad14, and Ad14P1.
Wang H, Ducournau C, Saydaminova K, Richter M, Yumul R, Ho M, Carter D, Zubieta C, Fender P, Lieber A
Journal of virology 2015 Nov;89(21):10841-59
Journal of virology 2015 Nov;89(21):10841-59
Desmoglein 2 depletion leads to increased migration and upregulation of the chemoattractant secretoneurin in melanoma cells.
Peitsch WK, Doerflinger Y, Fischer-Colbrie R, Huck V, Bauer AT, Utikal J, Goerdt S, Schneider SW
PloS one 2014 Feb 18;9(2):e89491
PloS one 2014 Feb 18;9(2):e89491
Structural and functional studies on the interaction of adenovirus fiber knobs and desmoglein 2.
Wang H, Yumul R, Cao H, Ran L, Fan X, Richter M, Epstein F, Gralow J, Zubieta C, Fender P, Lieber A
Journal of virology 2013 Nov;87(21):11346-62
Journal of virology 2013 Nov;87(21):11346-62
Pseudotyping the adenovirus serotype 5 capsid with both the fibre and penton of serotype 35 enhances vascular smooth muscle cell transduction.
Parker AL, White KM, Lavery CA, Custers J, Waddington SN, Baker AH
Gene therapy 2013 Dec;20(12):1158-64
Gene therapy 2013 Dec;20(12):1158-64
Assessment of desmosomal components (desmoglein 1-3, plakoglobin) in cardia mucosa in relation to gastroesophageal reflux disease and Helicobacter pylori infection.
Wex T, Kuester D, Mönkemüller K, Stahr A, Fry LC, Kandulski A, Kropf S, Roessner A, Malfertheiner P
Human pathology 2012 Oct;43(10):1745-54
Human pathology 2012 Oct;43(10):1745-54
Epithelial junction opener JO-1 improves monoclonal antibody therapy of cancer.
Beyer I, van Rensburg R, Strauss R, Li Z, Wang H, Persson J, Yumul R, Feng Q, Song H, Bartek J, Fender P, Lieber A
Cancer research 2011 Nov 15;71(22):7080-90
Cancer research 2011 Nov 15;71(22):7080-90
Multimerization of adenovirus serotype 3 fiber knob domains is required for efficient binding of virus to desmoglein 2 and subsequent opening of epithelial junctions.
Wang H, Li Z, Yumul R, Lara S, Hemminki A, Fender P, Lieber A
Journal of virology 2011 Jul;85(13):6390-402
Journal of virology 2011 Jul;85(13):6390-402
Characterization of full-length and proteolytic cleavage fragments of desmoglein-2 in native human colon and colonic epithelial cell lines.
Kolegraff K, Nava P, Laur O, Parkos CA, Nusrat A
Cell adhesion & migration 2011 Jul-Aug;5(4):306-14
Cell adhesion & migration 2011 Jul-Aug;5(4):306-14
Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14.
Wang H, Li ZY, Liu Y, Persson J, Beyer I, Möller T, Koyuncu D, Drescher MR, Strauss R, Zhang XB, Wahl JK 3rd, Urban N, Drescher C, Hemminki A, Fender P, Lieber A
Nature medicine 2011 Jan;17(1):96-104
Nature medicine 2011 Jan;17(1):96-104
Desmosome dynamics in migrating epithelial cells requires the actin cytoskeleton.
Roberts BJ, Pashaj A, Johnson KR, Wahl JK 3rd
Experimental cell research 2011 Dec 10;317(20):2814-22
Experimental cell research 2011 Dec 10;317(20):2814-22
Plakophilin 2 couples actomyosin remodeling to desmosomal plaque assembly via RhoA.
Godsel LM, Dubash AD, Bass-Zubek AE, Amargo EV, Klessner JL, Hobbs RP, Chen X, Green KJ
Molecular biology of the cell 2010 Aug 15;21(16):2844-59
Molecular biology of the cell 2010 Aug 15;21(16):2844-59
A missense variant in desmoglein-2 predisposes to dilated cardiomyopathy.
Posch MG, Posch MJ, Geier C, Erdmann B, Mueller W, Richter A, Ruppert V, Pankuweit S, Maisch B, Perrot A, Buttgereit J, Dietz R, Haverkamp W, Ozcelik C
Molecular genetics and metabolism 2008 Sep-Oct;95(1-2):74-80
Molecular genetics and metabolism 2008 Sep-Oct;95(1-2):74-80
Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly.
Bass-Zubek AE, Hobbs RP, Amargo EV, Garcia NJ, Hsieh SN, Chen X, Wahl JK 3rd, Denning MF, Green KJ
The Journal of cell biology 2008 May 19;181(4):605-13
The Journal of cell biology 2008 May 19;181(4):605-13
Carboxyl terminus of Plakophilin-1 recruits it to plasma membrane, whereas amino terminus recruits desmoplakin and promotes desmosome assembly.
Sobolik-Delmaire T, Katafiasz D, Wahl JK 3rd
The Journal of biological chemistry 2006 Jun 23;281(25):16962-70
The Journal of biological chemistry 2006 Jun 23;281(25):16962-70
Delineation of diversified desmoglein distribution in stratified squamous epithelia: implications in diseases.
Mahoney MG, Hu Y, Brennan D, Bazzi H, Christiano AM, Wahl JK 3rd
Experimental dermatology 2006 Feb;15(2):101-9
Experimental dermatology 2006 Feb;15(2):101-9
Mispolarization of desmosomal proteins and altered intercellular adhesion in autosomal dominant polycystic kidney disease.
Silberberg M, Charron AJ, Bacallao R, Wandinger-Ness A
American journal of physiology. Renal physiology 2005 Jun;288(6):F1153-63
American journal of physiology. Renal physiology 2005 Jun;288(6):F1153-63
Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells.
Lorch JH, Klessner J, Park JK, Getsios S, Wu YL, Stack MS, Green KJ
The Journal of biological chemistry 2004 Aug 27;279(35):37191-200
The Journal of biological chemistry 2004 Aug 27;279(35):37191-200
Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.
Chen X, Bonne S, Hatzfeld M, van Roy F, Green KJ
The Journal of biological chemistry 2002 Mar 22;277(12):10512-22
The Journal of biological chemistry 2002 Mar 22;277(12):10512-22
Intermediate filament-membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength.
Huen AC, Park JK, Godsel LM, Chen X, Bannon LJ, Amargo EV, Hudson TY, Mongiu AK, Leigh IM, Kelsell DP, Gumbiner BM, Green KJ
The Journal of cell biology 2002 Dec 23;159(6):1005-17
The Journal of cell biology 2002 Dec 23;159(6):1005-17
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Supportive validation
- Submitted by
- NSJ Bioreagents (provider)
- Main image
- Experimental details
- SDS-PAGE Analysis of Purified, BSA-Free DSG2 Antibody (clone 6D8). Confirmation of Integrity and Purity of the Antibody.
