Tissue expression
Cell line expression
Protein structure
CCM2
CCM2 scaffold proteinC7orf22, MGC4607, OSM
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Top validated antibodies |
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Proteintech Group | 26270-1-AP | 1 references | Polyclonal |
WB
EL
ICC
IHC |
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Atlas Antibodies | HPA020273 | 1 references | Polyclonal |
ICC
IHC |
|
LSBio | LS-C173242 | Monoclonal |
WB
ICC
IHC
|
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Novus Biologicals | NBP1-86730 | 2 references | Polyclonal |
WB
ICC
IHC
|
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Everest Biotech | EB07499 | Polyclonal |
WB
EL
ICC
FC |
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