BS9140

antibody from Bioworld Technology, Inc
Targeting: GADD45G CR6, DDIT2, GADD45gamma, GRP17
Provider product page for BS9140
Western blot
Immunohistochemistry

Antibody data

Product number
BS9140 - Provider product page
Provider
Bioworld Technology, Inc
Product name
GADD 45ÎÛ (S123) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 101-150 of Human GADD 45ÎÛ.
Description
Cell cycle progression is subject to arrest at G1 and G2 checkpoints in response to DNA damage, presumably to allow time for DNA repair prior to entry into S and M phase, respectively. The p53 tumor suppressor is required for one such G1 checkpoint and functions to upregulate expression of GADD 45 and p21. GADD 45 binds both Cdks and PCNA, a protein involved in DNA replication and repair. GADD 45 stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. Thus, it has been suggested that GADD 45 may serve as a link between the p53-dependent cell cycle checkpoint and DNA repair. GADD 45-like proteins, GADD 45ÉÇ and GADD 45ÎÛ, have been shown to be induced by environmental stresses. GADD 45ÉÇ and GADD 45ÎÛ are thought to induce p38/JNK activation via MEKK4 activation.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
GADD45G protein structure - BS9140 shown in red.