Ab099353

antibody from Aladdin Scientific Corporation

Targeting: DDB2 DDBB, FLJ34321, UV-DDB2, XPE

Western blot (Data presented on provider website)

Antibody Data

Product number

Ab099353

Provider

Aladdin Scientific Corporation

Product name

Recombinant DDB2 Antibody

Antibody type

Recombinant

Description

Rabbit anti Human DDB2 Antibody, Recombinant (R09-1D5), could be used for WB and so on.Application:WB: 1/500-1/1000Protein FunctionRequired for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

AA 350-427


Antibody clone number

R09-1D5

Vial size

100μl,10μl,1ml,50μl

Concentration

0,4 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.