Ab124351

antibody from Aladdin Scientific Corporation

Targeting: RAD21 hHR21, KIAA0078, SCC1

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

Ab124351

Provider

Aladdin Scientific Corporation

Product name

Recombinant Rad21 Antibody

Antibody type

Recombinant

Description

Rabbit anti Human Rad21 Antibody, Recombinant (R03-5I0), could be used for  WB, IHC, ICC, IF and so on.Application:· WB: 1/500-1/1000· IHC: 1/50-1/100 · ICC/IF: 1/50-1/200Protein Function：Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.

Reactivity

Human, Hamster

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

AA 600-631


Antibody clone number

R03-5I0

Vial size

100μl,10μl,1ml,50μl

Concentration

0,6 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.