FNab05836

antibody from FineTest Biotech
Targeting: NR1H3 LXR-a, LXRa, RLD-1
Provider product page for FNab05836
Western blot
ELISA
Immunocytochemistry

Antibody data

Product number
FNab05836 - Provider product page
Provider
FineTest Biotech
Product name
NR1H3 antibody
Antibody type
Monoclonal
Antigen
Recombinant protein fragment
Description
Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism(By similarity). Exhibits a ligand-dependent transcriptional activation activity(PubMed:25661920).
Reactivity
Human, Rat
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
nuclear receptor subfamily 1, group
H, member 3
Epitope
IgG2a
Isotype
IgG
Antibody clone number
7D2
Vial size
100¦Ìg
Concentration
Protein A+G purification
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
NR1H3 protein structure - FNab05836 shown in red.