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Immunoprecipitation
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [1]
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- Validations
- Flow cytometry [1]
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- Product number
- 350602 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#350602, RRID:AB_10662540
- Product name
- Purified anti-human CD11a
- Antibody type
- Monoclonal
- Antigen
- HLA-DR CTL line
- Description
- CD11a is a 170-180 kD type I transmembrane glycoprotein also known as LFA-1α chain and integrin αL subunit. CD11a non-covalently associates with integrin β2 (CD18) to form LFA-1. It is expressed on all leukocytes, including B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils. It is absent on non-hematopoietic tissues and platelets. CD11a plays a central role in leukocyte cell-cell interactions and is important in lymphocyte costimulation. CD11a/CD18 binds to ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50).
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation.
Lefort CT, Rossaint J, Moser M, Petrich BG, Zarbock A, Monkley SJ, Critchley DR, Ginsberg MH, Fässler R, Ley K
Blood 2012 May 3;119(18):4275-82
Blood 2012 May 3;119(18):4275-82
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood lymphocytes stained with PE anti-human CD11a (clone TS2/4, filled histogram) or PE mouse IgG1, κ isotype control (open histogram)
- Conjugate
- Unconjugated
