APR06880G

antibody from Leading Biology

Targeting: DEPTOR DEP.6, DEPDC6, FLJ12428

Western blot

Immunohistochemistry

Antibody data

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Validation data

Product number: APR06880G - Provider product page
Provider: Leading Biology
Product name: DEPTOR Antibody
Antibody type: Polyclonal
Description: DEPTOR is an mTOR (mammalian target of rapamycin)-interacting protein whose expression is negatively regualted by mTOR complex 1 (mTORC1) and mTORC2 (1). Loss of DEPTOR activates RP6SK1, Akt1, and SGK1, promotes cell growth and survival, and activates mTORC1 and mTORC2 kinase activities. DEPTOR expression is low in most cancers, but is often elevated in multiple myelomas (1). In respons to stimulation by mitogens, DEPTOR is rapidly phosphorylated leading to its ubiquitination and degradation, allowing mTOR to generate an auto-amplification loop to promotes its own full activation (2).
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

DEPTOR protein structure - APR06880G shown in red.