Antibody data
- Antibody Data
- Antigen structure
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- Product number
- AMM01919G - Provider product page
- Provider
- Leading Biology
- Product name
- SMAD6 Antibody (clone 4C8)
- Antibody type
- Monoclonal
- Description
- Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
- Reactivity
- Human
- Host
- Mouse
- Antibody clone number
- 4C8
- Storage
- Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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