H00057167-M03

Terada Y, Jo N, Arakawa Y, Sakakura M, Yamada Y, Ukai T, Kabata M, Mitsunaga K, Mineharu Y, Ohta S, Nakagawa M, Miyamoto S, Yamamoto T, Yamada Y
Cell reports 2019 Mar 5;26(10):2608-2621.e6

Early Gastric Cancer with Purely Enteroblastic Differentiation and No Conventional Adenocarcinoma Component.

Yamada R, Horiguchi SI, Onishi T, Motoi T, Hishima T
Case reports in pathology 2018;2018:3620293

Review with novel markers facilitates precise categorization of 41 cases of diagnostically challenging, "undifferentiated small round cell tumors". A clinicopathologic, immunophenotypic and molecular analysis.

Machado I, Yoshida A, Morales MGN, Abrahão-Machado LF, Navarro S, Cruz J, Lavernia J, Parafioriti A, Picci P, Llombart-Bosch A
Annals of diagnostic pathology 2018 Jun;34:1-12

HER2 is frequently overexpressed in hepatoid adenocarcinoma and gastric carcinoma with enteroblastic differentiation: a comparison of 35 cases to 334 gastric carcinomas of other histological types.

Fujimoto M, Matsuzaki I, Nishino M, Iwahashi Y, Warigaya K, Kojima F, Ono K, Murata SI
Journal of clinical pathology 2018 Jul;71(7):600-607

3,3'-Diindolylmethane stimulates exosomal Wnt11 autocrine signaling in human umbilical cord mesenchymal stem cells to enhance wound healing.

Shi H, Xu X, Zhang B, Xu J, Pan Z, Gong A, Zhang X, Li R, Sun Y, Yan Y, Mao F, Qian H, Xu W
Theranostics 2017;7(6):1674-1688

Germinoma with an extensive rhabdoid cell component centered at the corpus callosum.

Tajima S, Koda K
Medical molecular morphology 2017 Mar;50(1):52-58

Clinicopathological and molecular characterization of SMARCA4-deficient thoracic sarcomas with comparison to potentially related entities.

Yoshida A, Kobayashi E, Kubo T, Kodaira M, Motoi T, Motoi N, Yonemori K, Ohe Y, Watanabe SI, Kawai A, Kohno T, Kishimoto H, Ichikawa H, Hiraoka N
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2017 Jun;30(6):797-809

Clinicopathological features of alpha-fetoprotein producing early gastric cancer with enteroblastic differentiation.

Matsumoto K, Ueyama H, Matsumoto K, Akazawa Y, Komori H, Takeda T, Murakami T, Asaoka D, Hojo M, Tomita N, Nagahara A, Kajiyama Y, Yao T, Watanabe S
World journal of gastroenterology 2016 Sep 28;22(36):8203-10

Non-tumor tissue derived interleukin-17B activates IL-17RB/AKT/β-catenin pathway to enhance the stemness of gastric cancer.

Bie Q, Sun C, Gong A, Li C, Su Z, Zheng D, Ji X, Wu Y, Guo Q, Wang S, Xu H
Scientific reports 2016 May 5;6:25447

The zinc-finger transcription factor SALL4 is frequently expressed in human cancers: association with clinical outcome in squamous cell carcinoma but not in adenocarcinoma of the esophagus.

Kilic E, Tennstedt P, Högner A, Lebok P, Sauter G, Bokemeyer C, Izbicki JR, Wilczak W
Virchows Archiv : an international journal of pathology 2016 Apr;468(4):483-92

Clinicopathologic and immunohistochemical characteristics of gastric adenocarcinoma with enteroblastic differentiation: a study of 29 cases.

Murakami T, Yao T, Mitomi H, Morimoto T, Ueyama H, Matsumoto K, Saito T, Osada T, Nagahara A, Watanabe S
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2016 Apr;19(2):498-507

NRG1 and KITL Signal Downstream of Retinoic Acid in the Germline to Support Soma-Free Syncytial Growth of Differentiating Spermatogonia.

Chapman KM, Medrano GA, Chaudhary J, Hamra FK
Cell death discovery 2015;1

Differential SALL4 immunoexpression in malignant rhabdoid tumours and epithelioid sarcomas.

Yoshida A, Asano N, Kawai A, Kawamoto H, Nakazawa A, Kishimoto H, Kushima R
Histopathology 2015 Jan;66(2):252-61

ERG and SALL4 expressions in SMARCB1/INI1-deficient tumors: a useful tool for distinguishing epithelioid sarcoma from malignant rhabdoid tumor.

Kohashi K, Yamada Y, Hotokebuchi Y, Yamamoto H, Taguchi T, Iwamoto Y, Oda Y
Human pathology 2015 Feb;46(2):225-30

Clinicopathologic characteristics of SALL4-immunopositive hepatocellular carcinoma.

Shibahara J, Ando S, Hayashi A, Sakamoto Y, Hesegawa K, Kokudo N, Fukayama M
SpringerPlus 2014;3:721

Combination of hepatocellular markers is useful for prognostication in gastric hepatoid adenocarcinoma.

Osada M, Aishima S, Hirahashi M, Takizawa N, Takahashi S, Nakamura K, Tanaka M, Maehara Y, Takayanagi R, Oda Y
Human pathology 2014 Jun;45(6):1243-50

SALL4 immunohistochemistry in non-small-cell lung carcinomas.

Fujimoto M, Sumiyoshi S, Yoshizawa A, Sonobe M, Kobayashi M, Moriyoshi K, Kido A, Tanaka C, Koyanagi I, Date H, Haga H
Histopathology 2014 Jan;64(2):309-11

The transcription factor SALL4 regulates stemness of EpCAM-positive hepatocellular carcinoma.

Zeng SS, Yamashita T, Kondo M, Nio K, Hayashi T, Hara Y, Nomura Y, Yoshida M, Hayashi T, Oishi N, Ikeda H, Honda M, Kaneko S
Journal of hepatology 2014 Jan;60(1):127-34

Metastatic seminomas in lymph nodes: CD10 immunoreactivity can be a pitfall of differential diagnosis.

Ota Y, Iihara K, Ryu T, Morikawa T, Fukayama M
International journal of clinical and experimental pathology 2013;6(3):498-502

Mediastinal seminoma: a case report with special emphasis on SALL4 as a new immunocytochemical marker.

Iwamoto N, Ishida M, Yoshida K, Kagotani A, Iwai M, Okabe H
Diagnostic cytopathology 2013 Sep;41(9):821-4

Histone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cells.

Liu L, Souto J, Liao W, Jiang Y, Li Y, Nishinakamura R, Huang S, Rosengart T, Yang VW, Schuster M, Ma Y, Yang J
The Journal of biological chemistry 2013 Nov 29;288(48):34719-28

α-Fetoprotein-producing ovarian tumor in a postmenopausal woman with germ cell differentiation.

Meguro S, Yasuda M
Annals of diagnostic pathology 2013 Feb;17(1):140-4

α-Fetoprotein-producing gastric carcinoma and combined hepatocellular and cholangiocarcinoma show similar morphology but different histogenesis with respect to SALL4 expression.

Ikeda H, Sato Y, Yoneda N, Harada K, Sasaki M, Kitamura S, Sudo Y, Ooi A, Nakanuma Y
Human pathology 2012 Nov;43(11):1955-63

Immunoexpression of SALL4 in Wilms tumors and developing kidney.

Deisch J, Raisanen J, Rakheja D
Pathology oncology research : POR 2011 Sep;17(3):639-44

Specificity of brachyury in the distinction of chordoma from clear cell renal cell carcinoma and germ cell tumors: a study of 305 cases.

Sangoi AR, Karamchandani J, Lane B, Higgins JP, Rouse RV, Brooks JD, McKenney JK
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2011 Mar;24(3):425-9

β-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors.

Clark PE, Polosukhina D, Love H, Correa H, Coffin C, Perlman EJ, de Caestecker M, Moses HL, Zent R
The American journal of pathology 2011 Dec;179(6):3045-55

Expression pattern of stemness-related genes in human endometrial and endometriotic tissues.

Forte A, Schettino MT, Finicelli M, Cipollaro M, Colacurci N, Cobellis L, Galderisi U
Molecular medicine (Cambridge, Mass.) 2009 Nov-Dec;15(11-12):392-401

Markers that define stemness in ESC are unable to identify the totipotent cells in human preimplantation embryos.

Cauffman G, De Rycke M, Sermon K, Liebaers I, Van de Velde H
Human reproduction (Oxford, England) 2009 Jan;24(1):63-70

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Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: SALL4 Antibody (6E3) [H00057167-M03] - Analysis of SALL4 expression in NIH/3T3 (Cat # L018V1).

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: ELISA: SALL4 Antibody (6E3) [H00057167-M03] - Detection limit for recombinant GST tagged SALL4 is approximately 1ng/ml as a capture antibody.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Immunohistochemistry-Paraffin: SALL4 Antibody (6E3) [H00057167-M03] - Analysis of monoclonal antibody to SALL4 on formalin-fixed paraffin-embedded human testis. Antibody concentration 0.2 ug/ml