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LearnAF2447
antibody from Novus Biologicals
Targeting: IGF2R
CD222, CI-M6PR, CI-MPR, CIMPR, M6P-R, MPR1, MPR300, MPRI
Western blot
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [10]
- Comments [0]
- Validations
- Immunohistochemistry [1]
- Flow cytometry [1]
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- Product number
- AF2447 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal IGF-II R/IGF2R Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human IGF-II R/IGF2R in direct ELISAs and Western blots.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Blockade of IGF2R improves muscle regeneration and ameliorates Duchenne muscular dystrophy.
The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease.
Insulin Stimulates PI3K/AKT and Cell Adhesion to Promote the Survival of Individualized Human Embryonic Stem Cells.
mTORC1 regulates mannose-6-phosphate receptor transport and T-cell vulnerability to regulatory T cells by controlling kinesin KIF13A.
IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids.
A subset of bone marrow stromal cells regulate ATP-binding cassette gene expression via insulin-like growth factor-I in a leukemia cell line.
IGF2 actions on trophoblast in human placenta are regulated by the insulin-like growth factor 2 receptor, which can function as both a signaling and clearance receptor.
A critical role for IGF-II in memory consolidation and enhancement.
CREG inhibits migration of human vascular smooth muscle cells by mediating IGF-II endocytosis.
Urokinase induces survival or pro-apoptotic signals in human mesangial cells depending on the apoptotic stimulus.
Bella P, Farini A, Banfi S, Parolini D, Tonna N, Meregalli M, Belicchi M, Erratico S, D'Ursi P, Bianco F, Legato M, Ruocco C, Sitzia C, Sangiorgi S, Villa C, D'Antona G, Milanesi L, Nisoli E, Mauri P, Torrente Y
EMBO molecular medicine 2020 Jan 9;12(1):e11019
EMBO molecular medicine 2020 Jan 9;12(1):e11019
The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease.
Gerber H, Mosser S, Boury-Jamot B, Stumpe M, Piersigilli A, Goepfert C, Dengjel J, Albrecht U, Magara F, Fraering PC
Acta neuropathologica communications 2019 Jan 31;7(1):13
Acta neuropathologica communications 2019 Jan 31;7(1):13
Insulin Stimulates PI3K/AKT and Cell Adhesion to Promote the Survival of Individualized Human Embryonic Stem Cells.
Godoy-Parejo C, Deng C, Liu W, Chen G
Stem cells (Dayton, Ohio) 2019 Aug;37(8):1030-1041
Stem cells (Dayton, Ohio) 2019 Aug;37(8):1030-1041
mTORC1 regulates mannose-6-phosphate receptor transport and T-cell vulnerability to regulatory T cells by controlling kinesin KIF13A.
Ahmed KA, Xiang J
Cell discovery 2017;3:17011
Cell discovery 2017;3:17011
IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids.
Martín-Montañez E, Millon C, Boraldi F, Garcia-Guirado F, Pedraza C, Lara E, Santin LJ, Pavia J, Garcia-Fernandez M
Redox biology 2017 Oct;13:69-81
Redox biology 2017 Oct;13:69-81
A subset of bone marrow stromal cells regulate ATP-binding cassette gene expression via insulin-like growth factor-I in a leukemia cell line.
Benabbou N, Mirshahi P, Bordu C, Faussat AM, Tang R, Therwath A, Soria J, Marie JP, Mirshahi M
International journal of oncology 2014 Oct;45(4):1372-80
International journal of oncology 2014 Oct;45(4):1372-80
IGF2 actions on trophoblast in human placenta are regulated by the insulin-like growth factor 2 receptor, which can function as both a signaling and clearance receptor.
Harris LK, Crocker IP, Baker PN, Aplin JD, Westwood M
Biology of reproduction 2011 Mar;84(3):440-6
Biology of reproduction 2011 Mar;84(3):440-6
A critical role for IGF-II in memory consolidation and enhancement.
Chen DY, Stern SA, Garcia-Osta A, Saunier-Rebori B, Pollonini G, Bambah-Mukku D, Blitzer RD, Alberini CM
Nature 2011 Jan 27;469(7331):491-7
Nature 2011 Jan 27;469(7331):491-7
CREG inhibits migration of human vascular smooth muscle cells by mediating IGF-II endocytosis.
Han Y, Cui J, Tao J, Guo L, Guo P, Sun M, Kang J, Zhang X, Yan C, Li S
Experimental cell research 2009 Nov 15;315(19):3301-11
Experimental cell research 2009 Nov 15;315(19):3301-11
Urokinase induces survival or pro-apoptotic signals in human mesangial cells depending on the apoptotic stimulus.
Tkachuk N, Kiyan J, Tkachuk S, Kiyan R, Shushakova N, Haller H, Dumler I
The Biochemical journal 2008 Oct 15;415(2):265-73
The Biochemical journal 2008 Oct 15;415(2):265-73
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- IGF-II R/IGF2R R in Human Placenta. IGF-II R/IGF2R was detected in immersion fixed paraffin-embedded sections of human placenta using 10 µg/mL Goat Anti-Human IGF-II R/IGF2R Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2447) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of IGF-II R/IGF2R in Human Monocytes by Flow Cytometry. Human whole blood monocytes were stained with Goat Anti-Human IGF-II R/IGF2R Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2447, filled histogram) or control antibody (Catalog # AB-108-C, open histogram), followed by Phycoerythrin-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0107).
