BS2448

antibody from Bioworld Technology, Inc

Targeting: HGS Hrs, Vps27, ZFYVE8

Immunocytochemistry

Immunohistochemistry

Antibody data

Submit

Validation data

Product number: BS2448 - Provider product page
Provider: Bioworld Technology, Inc
Proper citation: Bioworld Technology Cat#BS2448, RRID:AB_1663615
Product name: Hrs (R481) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic peptide, corresponding to amino acids 461-510 of Human Hrs.
Description: The hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is a zinc-finger protein that interacts with STAM and undergoes tyrosine phosphorylation in response to IL2, CSF2 or HGF. Hrs is involved in intracellular trafficking and signal transduction and is associated with early endosomes. H contains a phosphatidylinositol 3-phosphate-binding domain that contributes to its endosomal targeting, where Hrs colocalizes with Clathrin via a Clathrin box motif at the carboxy terminus of Hrs. Hrs is essential for ventral folding morphogenesis and shares structual similarity to the yeast protein Vps27p, which is involved in vacuolar protein sorting. The human Hrs gene, which maps to chromosome 17q25, enodes a 777 amino acid protein. In Schwann cells, Hrs colocalizes at endosomes with the tumor suppressor protein schwannomin, suggesting a role for schwannomin in Hrs-mediated cell signaling.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

HGS protein structure - BS2448 shown in red.