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- Antibody Data
- Antigen structure
- References [26]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 22586-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#22586-1-AP, RRID:AB_11182588
- Product name
- TFAM antibody
- Antibody type
- Polyclonal
- Description
- TFAM antibody (Cat. #22586-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.
Transcriptomic Profiling Reveals the Antiapoptosis and Antioxidant Stress Effects of Fos in Ischemic Stroke.
Naringenin Attenuates Non-Alcoholic Fatty Liver Disease by Enhancing Energy Expenditure and Regulating Autophagy via AMPK.
Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm.
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
Hypoxic training upregulates mitochondrial turnover and angiogenesis of skeletal muscle in mice.
Icaritin Attenuates Lipid Accumulation by Increasing Energy Expenditure and Autophagy Regulated by Phosphorylating AMPK.
Fucoxanthin rescues dexamethasone induced C2C12 myotubes atrophy.
Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA.
Nobiletin activates thermogenesis of brown and white adipose tissue in high-fat diet-fed C57BL/6 mice by shaping the gut microbiota.
Vascular endothelial growth factor alleviates mitochondrial dysfunction and suppression of mitochondrial biogenesis in models of Alzheimer's disease.
β2-adrenoreceptor agonist ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of mitochondrial biogenesis.
A recessive variant in TFAM causes mtDNA depletion associated with primary ovarian insufficiency, seizures, intellectual disability and hearing loss.
Pulmonary Exposure to Copper Oxide Nanoparticles Leads to Neurotoxicity via Oxidative Damage and Mitochondrial Dysfunction.
ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA.
Danqi Pill Protects Against Heart Failure Post-Acute Myocardial Infarction via HIF-1α/PGC-1α Mediated Glucose Metabolism Pathway.
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride.
Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics.
Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1α pathway in skeletal muscle.
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.
Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism.
Hepatic Mitochondrial Oxidative Metabolism and Lipogenesis Synergistically Adapt to Mediate Healthy Embryonic-to-Neonatal Transition in Chicken.
Promotion of Mitochondrial Biogenesis via Activation of AMPK-PGC1ɑ Signaling Pathway by Ginger (Zingiber officinale Roscoe) Extract, and Its Major Active Component 6-Gingerol.
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro.
Yang Y, Li C, Gu X, Zhen J, Zhu S, Lv T, Wan Q, Liu Y
Frontiers in cell and developmental biology 2021;9:700195
Frontiers in cell and developmental biology 2021;9:700195
Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.
Tai H, Jiang XL, Song N, Xiao HH, Li Y, Cheng MJ, Yin XM, Chen YR, Yang GL, Jiang XY, Kuang JS, Lan ZM, Jia LQ
Frontiers in medicine 2021;8:617393
Frontiers in medicine 2021;8:617393
Transcriptomic Profiling Reveals the Antiapoptosis and Antioxidant Stress Effects of Fos in Ischemic Stroke.
Mu Q, Zhang Y, Gu L, Gerner ST, Qiu X, Tao Q, Pang J, Dipritu G, Zhang L, Yin S, Jiang Y, Peng J
Frontiers in neurology 2021;12:728984
Frontiers in neurology 2021;12:728984
Naringenin Attenuates Non-Alcoholic Fatty Liver Disease by Enhancing Energy Expenditure and Regulating Autophagy via AMPK.
Yang Y, Wu Y, Zou J, Wang YH, Xu MX, Huang W, Yu DJ, Zhang L, Zhang YY, Sun XD
Frontiers in pharmacology 2021;12:687095
Frontiers in pharmacology 2021;12:687095
Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm.
Oller J, Gabandé-Rodríguez E, Ruiz-Rodríguez MJ, Desdín-Micó G, Aranda JF, Rodrigues-Diez R, Ballesteros-Martínez C, Blanco EM, Roldan-Montero R, Acuña P, Forteza Gil A, Martín-López CE, Nistal JF, Lino Cardenas CL, Lindsay ME, Martín-Ventura JL, Briones AM, Redondo JM, Mittelbrunn M
Circulation 2021 May 25;143(21):2091-2109
Circulation 2021 May 25;143(21):2091-2109
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
Yang M, Cui Y, Song J, Cui C, Wang L, Liang K, Wang C, Sha S, He Q, Hu H, Guo X, Zang N, Sun L, Chen L
Biochemical and biophysical research communications 2021 Mar 26;546:74-82
Biochemical and biophysical research communications 2021 Mar 26;546:74-82
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
Tai H, Jiang XL, Lan ZM, Li Y, Kong L, Yao SC, Song N, Lv MJ, Wu J, Yang P, Xiao XS, Yang GL, Kuang JS, Jia LQ
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
Hypoxic training upregulates mitochondrial turnover and angiogenesis of skeletal muscle in mice.
Zhao YC, Guo W, Gao BH
Life sciences 2021 Mar 11;291:119340
Life sciences 2021 Mar 11;291:119340
Icaritin Attenuates Lipid Accumulation by Increasing Energy Expenditure and Autophagy Regulated by Phosphorylating AMPK.
Wu Y, Yang Y, Li F, Zou J, Wang YH, Xu MX, Wang YL, Li RX, Sun YT, Lu S, Zhang YY, Sun XD
Journal of clinical and translational hepatology 2021 Jun 28;9(3):373-383
Journal of clinical and translational hepatology 2021 Jun 28;9(3):373-383
Fucoxanthin rescues dexamethasone induced C2C12 myotubes atrophy.
Zhiyin L, Jinliang C, Qiunan C, Yunfei Y, Qian X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jul;139:111590
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jul;139:111590
Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA.
Zhao M, Liu S, Wang C, Wang Y, Wan M, Liu F, Gong M, Yuan Y, Chen Y, Cheng J, Lu Y, Liu J
ACS nano 2021 Jan 26;15(1):1519-1538
ACS nano 2021 Jan 26;15(1):1519-1538
Nobiletin activates thermogenesis of brown and white adipose tissue in high-fat diet-fed C57BL/6 mice by shaping the gut microbiota.
Kou G, Li P, Hu Y, Chen H, Nyantakyiwaa Amoah A, Seydou Traore S, Cui Z, Lyu Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21267
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21267
Vascular endothelial growth factor alleviates mitochondrial dysfunction and suppression of mitochondrial biogenesis in models of Alzheimer's disease.
Liu X, Chu B, Jin S, Li M, Xu Y, Yang H, Feng Z, Bi J, Wang P
The International journal of neuroscience 2021 Feb;131(2):154-162
The International journal of neuroscience 2021 Feb;131(2):154-162
β2-adrenoreceptor agonist ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of mitochondrial biogenesis.
Chen N, Ge MM, Li DY, Wang XM, Liu DQ, Ye DW, Tian YK, Zhou YQ, Chen JP
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112331
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112331
A recessive variant in TFAM causes mtDNA depletion associated with primary ovarian insufficiency, seizures, intellectual disability and hearing loss.
Ullah F, Rauf W, Khan K, Khan S, Bell KM, de Oliveira VC, Tariq M, Bakhshalizadeh S, Touraine P, Katsanis N, Sinclair A, He S, Tucker EJ, Baig SM, Davis EE
Human genetics 2021 Dec;140(12):1733-1751
Human genetics 2021 Dec;140(12):1733-1751
Pulmonary Exposure to Copper Oxide Nanoparticles Leads to Neurotoxicity via Oxidative Damage and Mitochondrial Dysfunction.
Zhou H, Yao L, Jiang X, Sumayyah G, Tu B, Cheng S, Qin X, Zhang J, Zou Z, Chen C
Neurotoxicity research 2021 Aug;39(4):1160-1170
Neurotoxicity research 2021 Aug;39(4):1160-1170
ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA.
Shu L, Hu C, Xu M, Yu J, He H, Lin J, Sha H, Lu B, Engelender S, Guan M, Song Z
The EMBO journal 2021 Apr 15;40(8):e106283
The EMBO journal 2021 Apr 15;40(8):e106283
Danqi Pill Protects Against Heart Failure Post-Acute Myocardial Infarction via HIF-1α/PGC-1α Mediated Glucose Metabolism Pathway.
Zhang Q, Guo D, Wang Y, Wang X, Wang Q, Wu Y, Li C, Wang W, Wang Y
Frontiers in pharmacology 2020;11:458
Frontiers in pharmacology 2020;11:458
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride.
Zhao Q, Tian Z, Zhou G, Niu Q, Chen J, Li P, Dong L, Xia T, Zhang S, Wang A
Theranostics 2020;10(11):4822-4838
Theranostics 2020;10(11):4822-4838
Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics.
Rey T, Zaganelli S, Cuillery E, Vartholomaiou E, Croisier M, Martinou JC, Manley S
Nature cell biology 2020 Oct;22(10):1180-1186
Nature cell biology 2020 Oct;22(10):1180-1186
Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1α pathway in skeletal muscle.
Guo A, Li K, Xiao Q
Biochemical and biophysical research communications 2020 Jun 11;526(4):1069-1076
Biochemical and biophysical research communications 2020 Jun 11;526(4):1069-1076
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.
Chung KW, Dhillon P, Huang S, Sheng X, Shrestha R, Qiu C, Kaufman BA, Park J, Pei L, Baur J, Palmer M, Susztak K
Cell metabolism 2019 Oct 1;30(4):784-799.e5
Cell metabolism 2019 Oct 1;30(4):784-799.e5
Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism.
Lv X, Wang X, Wang Y, Zhou D, Li W, Wilson JX, Chang H, Huang G
Aging 2019 Nov 22;11(22):10356-10373
Aging 2019 Nov 22;11(22):10356-10373
Hepatic Mitochondrial Oxidative Metabolism and Lipogenesis Synergistically Adapt to Mediate Healthy Embryonic-to-Neonatal Transition in Chicken.
Surugihalli C, Porter TE, Chan A, Farley LS, Maguire M, Zhang C, Kattapuram N, Muyyarikkandy MS, Liu HC, Sunny NE
Scientific reports 2019 Dec 27;9(1):20167
Scientific reports 2019 Dec 27;9(1):20167
Promotion of Mitochondrial Biogenesis via Activation of AMPK-PGC1ɑ Signaling Pathway by Ginger (Zingiber officinale Roscoe) Extract, and Its Major Active Component 6-Gingerol.
Deng X, Zhang S, Wu J, Sun X, Shen Z, Dong J, Huang J
Journal of food science 2019 Aug;84(8):2101-2111
Journal of food science 2019 Aug;84(8):2101-2111
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro.
Zhu E, Yang Y, Zhang J, Li Y, Li C, Chen L, Sun B
Oncotarget 2016 Dec 6;7(49):81077-81089
Oncotarget 2016 Dec 6;7(49):81077-81089
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 22586-1-AP(TFAM antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TFAM antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TFAM. This antibody recognizes human antigen. The TFAM antibody has been validated for the following applications: ELISA, WB, IHC analysis.
