Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 13285-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13285-1-AP, RRID:AB_2122651
- Product name
- ZBP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ZBP1 antibody (Cat. #13285-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Tumors cells with mismatch repair deficiency induce hyperactivation of pyroptosis resistant to cell membrane damage but are more sensitive to co-treatment of IFN-γ and TNF-α to PANoptosis.
Transcriptomic analysis reveals molecular characterization and immune landscape of PANoptosis-related genes in atherosclerosis.
S100A8/A9(hi) neutrophils induce mitochondrial dysfunction and PANoptosis in endothelial cells via mitochondrial complex I deficiency during sepsis.
The anti-cancer drug candidate CBL0137 induced necroptosis via forming left-handed Z-DNA and its binding protein ZBP1 in liver cells.
Analysis of the role of PANoptosis in seizures via integrated bioinformatics analysis and experimental validation.
PANoptosis in vascular smooth muscle cells regulated by TNF-α/IL-1β can be a new target for alleviating the progression of abdominal aortic aneurysm.
SARS-CoV-2 infection of polarized human airway epithelium induces necroptosis that causes airway epithelial barrier dysfunction.
DNA sensor-associated type I interferon signaling is increased in ulcerative colitis and induces JAK-dependent inflammatory cell death in colonic organoids.
Sperm-Associated Antigen 9 Promotes Influenza A Virus-Induced Cell Death via the c-Jun N-Terminal Kinase Signaling Pathway.
Oxidative stress induces Z-DNA-binding protein 1-dependent activation of microglia via mtDNA released from retinal pigment epithelial cells.
Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells.
Li H, Ni H, Li Y, Zhou A, Qin X, Li Y, Che L, Mo H, Qin C, Li J
Cell death discovery 2024 May 13;10(1):227
Cell death discovery 2024 May 13;10(1):227
Transcriptomic analysis reveals molecular characterization and immune landscape of PANoptosis-related genes in atherosclerosis.
Zheng Z, Li K, Yang Z, Wang X, Shen C, Zhang Y, Lu H, Yin Z, Sha M, Ye J, Zhu L
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jun;73(6):961-978
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jun;73(6):961-978
S100A8/A9(hi) neutrophils induce mitochondrial dysfunction and PANoptosis in endothelial cells via mitochondrial complex I deficiency during sepsis.
Wang Y, Shi Y, Shao Y, Lu X, Zhang H, Miao C
Cell death & disease 2024 Jun 28;15(6):462
Cell death & disease 2024 Jun 28;15(6):462
The anti-cancer drug candidate CBL0137 induced necroptosis via forming left-handed Z-DNA and its binding protein ZBP1 in liver cells.
Li J, Tang M, Ke RX, Li PL, Sheng ZG, Zhu BZ
Toxicology and applied pharmacology 2024 Jan;482:116765
Toxicology and applied pharmacology 2024 Jan;482:116765
Analysis of the role of PANoptosis in seizures via integrated bioinformatics analysis and experimental validation.
Liu Y, Chang Y, Jiang X, Mei H, Cao Y, Wu D, Xie R, Jiang W, Vasquez E, Wu Y, Lin S, Cao Y
Heliyon 2024 Feb 29;10(4):e26219
Heliyon 2024 Feb 29;10(4):e26219
PANoptosis in vascular smooth muscle cells regulated by TNF-α/IL-1β can be a new target for alleviating the progression of abdominal aortic aneurysm.
Li K, Wei M, Zhang D, Zhai S, Liu H
Physiological genomics 2024 Feb 1;56(2):158-166
Physiological genomics 2024 Feb 1;56(2):158-166
SARS-CoV-2 infection of polarized human airway epithelium induces necroptosis that causes airway epithelial barrier dysfunction.
Hao S, Ning K, Kuz CA, Xiong M, Zou W, Park SY, McFarlin S, Yan Z, Qiu J
Journal of medical virology 2023 Sep;95(9):e29076
Journal of medical virology 2023 Sep;95(9):e29076
DNA sensor-associated type I interferon signaling is increased in ulcerative colitis and induces JAK-dependent inflammatory cell death in colonic organoids.
Flood P, Fanning A, Woznicki JA, Crowley T, Christopher A, Vaccaro A, Houston A, McSweeney S, Ross S, Hogan A, Brint E, Skowyra A, Bustamante M, Ambrose M, Moloney G, MacSharry J, Hammarström ML, Hurley M, Fitzgibbons C, Quigley EMM, Shanahan F, Zulquernain SA, McCarthy J, Dodson GS, Dabbagh K, McRae BL, Melgar S, Nally K
American journal of physiology. Gastrointestinal and liver physiology 2022 Nov 1;323(5):G439-G460
American journal of physiology. Gastrointestinal and liver physiology 2022 Nov 1;323(5):G439-G460
Sperm-Associated Antigen 9 Promotes Influenza A Virus-Induced Cell Death via the c-Jun N-Terminal Kinase Signaling Pathway.
Gui R, Zheng H, Ma L, Liu R, Lin X, Ke X, Ye C, Jian X, Chen Q
mBio 2022 Jun 28;13(3):e0061522
mBio 2022 Jun 28;13(3):e0061522
Oxidative stress induces Z-DNA-binding protein 1-dependent activation of microglia via mtDNA released from retinal pigment epithelial cells.
Saada J, McAuley RJ, Marcatti M, Tang TZ, Motamedi M, Szczesny B
The Journal of biological chemistry 2022 Jan;298(1):101523
The Journal of biological chemistry 2022 Jan;298(1):101523
Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells.
Szczesny B, Marcatti M, Ahmad A, Montalbano M, Brunyánszki A, Bibli SI, Papapetropoulos A, Szabo C
Scientific reports 2018 Jan 17;8(1):914
Scientific reports 2018 Jan 17;8(1):914
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 13285-1-AP(ZBP1 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 13285-1-AP(ZBP1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ZBP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ZBP1. This antibody recognizes human antigen. The ZBP1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.