659702

antibody from BioLegend
Targeting: NLRC4 CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, ipaf
Provider product page for 659702
Western blot
Immunocytochemistry

Antibody data

Product number
659702 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#659702, RRID:AB_2563347
Product name
Purified anti-NLRC4 (IPAF)
Antibody type
Monoclonal
Antigen
Partial human NLRC4 recombinant protein (1-88 aa)
Description
NLRC4 , also known as IPAF, is a member of the NOD-like receptor (NLR) family. The NLR proteins share a conserved DNA-binding NACHT domain, a caspase recruitment domain (CARD), and a leucine-rich repeat (LRR) domain responsible for pathogen pattern recognition. NLRC4 was found to play an important role in the innate immune response against bacterial infection. During Gram-negative bacteria infections, such as Shigella, Salmonella, Legionella, or Pseudomonas, NLRC4 detects and is activated by translocated bacterial flagellin or PrgJ-like rod proteins subsequently resulting in the assembly of the NLRC4 inflammasome. The activated inflammasome drives proteolytic activation of caspase-1, leading to the processing and secretion of the proinflamatory cytokines IL-1β and IL-18.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
6H9B13
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
NLRC4 protein structure - 659702 shown in red.