Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 12486-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12486-1-AP, RRID:AB_2090661
- Product name
- CYP46A1 antibody
- Antibody type
- Polyclonal
- Description
- CYP46A1 antibody (Cat. #12486-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Isocitrate dehydrogenase 1 mutation enhances 24(S)-hydroxycholesterol production and alters cholesterol homeostasis in glioma.
NPC1 enables cholesterol mobilization during long-term potentiation that can be restored in Niemann-Pick disease type C by CYP46A1 activation.
24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure.
H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment.
Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate.
Yang R, Zhao Y, Gu Y, Yang Y, Gao X, Yuan Y, Xiao L, Zhang J, Sun C, Yang H, Qin J, Li J, Zhang F, Zhang L, Ye J
Oncogene 2020 Oct;39(40):6340-6353
Oncogene 2020 Oct;39(40):6340-6353
NPC1 enables cholesterol mobilization during long-term potentiation that can be restored in Niemann-Pick disease type C by CYP46A1 activation.
Mitroi DN, Pereyra-Gómez G, Soto-Huelin B, Senovilla F, Kobayashi T, Esteban JA, Ledesma MD
EMBO reports 2019 Nov 5;20(11):e48143
EMBO reports 2019 Nov 5;20(11):e48143
24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure.
Ishikawa M, Yoshitomi T, Zorumski CF, Izumi Y
Scientific reports 2016 Sep 22;6:33886
Scientific reports 2016 Sep 22;6:33886
H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment.
Ali-Rahmani F, Grigson PS, Lee S, Neely E, Connor JR, Schengrund CL
Neurobiology of aging 2014 Jun;35(6):1511.e1-12
Neurobiology of aging 2014 Jun;35(6):1511.e1-12
Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate.
Zhou M, Li P, Tan L, Qu S, Ying QL, Song H
Journal of cellular biochemistry 2010 Feb 15;109(3):606-14
Journal of cellular biochemistry 2010 Feb 15;109(3):606-14
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 12486-1-AP(CYP46A1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CYP46A1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CYP46A1. This antibody recognizes human,mouse,rat antigen. The CYP46A1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.