10-7557-25

antibody from ABEOMICS Inc.
Targeting: BCL6 BCL5, BCL6A, LAZ3, ZBTB27, ZNF51
Provider product page for 10-7557-25

Antibody data

Product number
10-7557-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-BCL-6 Antibody
Antibody type
Monoclonal
Description
BCL6 (B-cell lymphoma 6) is a 95 kDa zinc finger transcription factor and contains an N-terminal POZ domain. BCL6 is a transcriptional repressor and a master regulator of the germinal center (GC) B cell phenotype controlling its development and growth. BCL-6 modulates IL-4, BCR, and CD40L signals for normal B cell development. Altered BCL6 protein expression is implicated in pathogenesis of diverse human hematologic malignancies, especially in the diffuse large B cell lymphoma (DLBCL), the most common lymphoma in adults. BCL6 suppresses the expression of p53 (also known as tp53) tumor suppressor gene and modulates DNA damage-induced apoptotic responses in GC B cells.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant BCL-6
protein (amino acids 200-401) was u
sed as the immunogen for this antib
ody.
Isotype
IgG
Antibody clone number
ABM44G9
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
BCL6 protein structure - 10-7557-25 shown in red.