Tissue expression
Cell line expression
MAPK10
gene productJNK3, p493F12, p54bSAPK, PRKM10
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
- Description
- Mitogen-activated protein kinase 10
- Tissue specificity
- Tissue enhanced (brain)
- Predicted location
- Intracellular
- Protein family
- Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
RAS pathway related proteins
- Chromosome
- 4 (85990007 - 86594625)
- Ensembl ID
- ENSG00000109339 (ver. 103.38)
- Orthologs
- Mouse Mapk10: ENSMUSG00000046709
- UniProt
- P53779
- neXtProt
- NX_P53779
Human splice variants
Mouse splice variants
Ensembl | UniProt | RefSeq | Entrez |
---|---|---|---|
ENSMUST00000086854 ENSMUSP00000084065 |
NP_001297614.1 NP_001297614 NP_001305060.1 NP_001305060 | Mapk10 26414 | |
ENSMUST00000112846 ENSMUSP00000108467 |
Mapk10 26414 | ||
ENSMUST00000112847 ENSMUSP00000108468 |
Mapk10 26414 | ||
ENSMUST00000112848 ENSMUSP00000108469 |
Mapk10 26414 | ||
ENSMUST00000128869 ENSMUSP00000143448 |
Mapk10 26414 | ||
ENSMUST00000133069 ENSMUSP00000143609 |
Mapk10 26414 | ||
ENSMUST00000141573 ENSMUSP00000142798 |
Mapk10 26414 | ||
ENSMUST00000170792 ENSMUSP00000127193 |
Mapk10 26414 | ||
ENSMUST00000238446 ENSMUSP00000158744 |
NP_001305031.1 NP_001305031 NP_001297615.1 NP_001297615 NP_001075036.1 NP_001075036 NP_001297612.1 NP_001297612 NP_033184.2 NP_033184 | Mapk10 26414 |
* nTPM: Normalized TPM levels represent consensus gene expression calculated using two data sets. Read more
RNA data sourced from Human Protein Atlas.
Featured antibodies
![]() |
![]() |
0 references | Polyclonal |
WB
ICC |