BS6706

antibody from Bioworld Technology, Inc
Targeting: MAPK10 JNK3, p493F12, p54bSAPK, PRKM10
Provider product page for BS6706
Western blot
Immunohistochemistry

Antibody data

Product number
BS6706 - Provider product page
Provider
Bioworld Technology, Inc
Product name
JNK3 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human JNK3.
Description
MAPK10 (JNK3) is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuron-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways of neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 (CDK5) can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
MAPK10 protein structure - BS6706 shown in red.