BS60516

antibody from Bioworld Technology, Inc
Targeting: IL3 IL-3, MCGF, MGC79398, MGC79399, MULTI-CSF
Provider product page for BS60516

Antibody data

Product number
BS60516 - Provider product page
Provider
Bioworld Technology, Inc
Product name
IL3 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human IL3.
Description
Interleukin-3, or IL-3, is a pleiotropic cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL-3 not only supports growth of both pluripotent stem cells and the more differentiated committed progenitors, but it also stimulates the functional activity of some fully differentiated cells. IL-3 has also been shown to protect mast cells from undergoing apoptosis. IL-3 exerts its biological effects through a receptor which consists of a ligand-specific Ï« subunit and a signal transducing ÉÇ subunit common to the IL-3/IL-5/GM-CSF receptors. The carboxy terminus of the ÉÇ subunit has been shown to be necessary for activation of the MAP kinase signaling pathway. Although the IL-3 receptor has no intrinsic kinase activity, stimulation with IL-3 leads to tyrosine phosphorylation of the JAK/Tyk 2 family member, JAK2, which in turn activates and causes nuclear translocation of Stat5a and Stat5b.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -21°C long term. Avoid freeze-thaw cycles.
IL3 protein structure - BS60516 shown in red.