ACVR1B

This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Description

activin A receptor type 1B

Protein family

Cancer-related genes, Disease related genes, Enzymes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Protein evidence (Peptideatlas)

Chromosome

12:q13.13 (51951699 - 51997078)

Ensembl ID

ENSG00000135503  (ver. 99.38)

Orthologs

Mouse Acvr1b: ENSMUSG00000000532

UniProt

P36896

neXtProt

NX_P36896

Human splice variants
Mouse splice variants