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- References [29]
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- Product number
- ABIN151086 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-RAD50 Homolog (S. Cerevisiae) (RAD50) (C-Term) antibody
- Antibody type
- Polyclonal
- Description
- Unpurified
- Reactivity
- Human, Mouse, Hamster
- Host
- Rabbit
- Epitope
- C-Term
- Vial size
- 0.1 mL
- Storage
- Store at 4°C. Do not freeze.
- Handling
- Do not freeze.
Submitted references Replication fork integrity and intra-S phase checkpoint suppress gene amplification.
Nijmegen breakage syndrome detected by newborn screening for T cell receptor excision circles (TRECs).
Mitochondrial dysfunction in a novel form of autosomal recessive ataxia.
A two-step mechanism for TRF2-mediated chromosome-end protection.
The Mre11 nuclease is critical for the sensitivity of cells to Chk1 inhibition.
Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses.
PALB2 self-interaction controls homologous recombination.
The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination.
Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infection.
A glycine-arginine domain in control of the human MRE11 DNA repair protein.
Adenovirus type 5 early region 1B 55-kDa oncoprotein can promote cell transformation by a mechanism independent from blocking p53-activated transcription.
Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance.
Mdm2 promotes genetic instability and transformation independent of p53.
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling.
DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models.
Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells.
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
Mre11-Rad50-Nbs1 complex is activated by hypertonicity.
Active role for nibrin in the kinetics of atm activation.
The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1.
Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair.
Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.
Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks.
Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression.
Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation.
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.
Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients.
Human MRE11 is inactivated in mismatch repair-deficient cancers.
Kondratova A, Watanabe T, Marotta M, Cannon M, Segall AM, Serre D, Tanaka H
Nucleic acids research 2015 Mar 11;43(5):2678-90
Nucleic acids research 2015 Mar 11;43(5):2678-90
Nijmegen breakage syndrome detected by newborn screening for T cell receptor excision circles (TRECs).
Patel JP, Puck JM, Srinivasan R, Brown C, Sunderam U, Kundu K, Brenner SE, Gatti RA, Church JA
Journal of clinical immunology 2015 Feb;35(2):227-33
Journal of clinical immunology 2015 Feb;35(2):227-33
Mitochondrial dysfunction in a novel form of autosomal recessive ataxia.
Murad NA, Cullen JK, McKenzie M, Ryan MT, Thorburn D, Gueven N, Kobayashi J, Birrell G, Yang J, Dörk T, Becherel O, Grattan-Smith P, Lavin MF
Mitochondrion 2013 May;13(3):235-45
Mitochondrion 2013 May;13(3):235-45
A two-step mechanism for TRF2-mediated chromosome-end protection.
Okamoto K, Bartocci C, Ouzounov I, Diedrich JK, Yates JR 3rd, Denchi EL
Nature 2013 Feb 28;494(7438):502-5
Nature 2013 Feb 28;494(7438):502-5
The Mre11 nuclease is critical for the sensitivity of cells to Chk1 inhibition.
Thompson R, Montano R, Eastman A
PloS one 2012;7(8):e44021
PloS one 2012;7(8):e44021
Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses.
He J, Shi LZ, Truong LN, Lu CS, Razavian N, Li Y, Negrete A, Shiloach J, Berns MW, Wu X
The Journal of biological chemistry 2012 Sep 14;287(38):31747-56
The Journal of biological chemistry 2012 Sep 14;287(38):31747-56
PALB2 self-interaction controls homologous recombination.
Buisson R, Masson JY
Nucleic acids research 2012 Nov 1;40(20):10312-23
Nucleic acids research 2012 Nov 1;40(20):10312-23
The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination.
Lu CS, Truong LN, Aslanian A, Shi LZ, Li Y, Hwang PY, Koh KH, Hunter T, Yates JR 3rd, Berns MW, Wu X
The Journal of biological chemistry 2012 Dec 21;287(52):43984-94
The Journal of biological chemistry 2012 Dec 21;287(52):43984-94
Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infection.
Karen KA, Hoey PJ, Young CS, Hearing P
Journal of virology 2009 May;83(9):4565-73
Journal of virology 2009 May;83(9):4565-73
A glycine-arginine domain in control of the human MRE11 DNA repair protein.
Déry U, Coulombe Y, Rodrigue A, Stasiak A, Richard S, Masson JY
Molecular and cellular biology 2008 May;28(9):3058-69
Molecular and cellular biology 2008 May;28(9):3058-69
Adenovirus type 5 early region 1B 55-kDa oncoprotein can promote cell transformation by a mechanism independent from blocking p53-activated transcription.
Härtl B, Zeller T, Blanchette P, Kremmer E, Dobner T
Oncogene 2008 Jun 12;27(26):3673-84
Oncogene 2008 Jun 12;27(26):3673-84
Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance.
Chan N, Koritzinsky M, Zhao H, Bindra R, Glazer PM, Powell S, Belmaaza A, Wouters B, Bristow RG
Cancer research 2008 Jan 15;68(2):605-14
Cancer research 2008 Jan 15;68(2):605-14
Mdm2 promotes genetic instability and transformation independent of p53.
Bouska A, Lushnikova T, Plaza S, Eischen CM
Molecular and cellular biology 2008 Aug;28(15):4862-74
Molecular and cellular biology 2008 Aug;28(15):4862-74
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling.
Stewart GS, Stankovic T, Byrd PJ, Wechsler T, Miller ES, Huissoon A, Drayson MT, West SC, Elledge SJ, Taylor AM
Proceedings of the National Academy of Sciences of the United States of America 2007 Oct 23;104(43):16910-5
Proceedings of the National Academy of Sciences of the United States of America 2007 Oct 23;104(43):16910-5
DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models.
Sedelnikova OA, Nakamura A, Kovalchuk O, Koturbash I, Mitchell SA, Marino SA, Brenner DJ, Bonner WM
Cancer research 2007 May 1;67(9):4295-302
Cancer research 2007 May 1;67(9):4295-302
Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells.
Rink L, Slupianek A, Stoklosa T, Nieborowska-Skorska M, Urbanska K, Seferynska I, Reiss K, Skorski T
Blood 2007 Jul 15;110(2):651-60
Blood 2007 Jul 15;110(2):651-60
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y
The Journal of biological chemistry 2006 Oct 13;281(41):30814-23
The Journal of biological chemistry 2006 Oct 13;281(41):30814-23
Mre11-Rad50-Nbs1 complex is activated by hypertonicity.
Sheen MR, Kim SW, Jung JY, Ahn JY, Rhee JG, Kwon HM, Woo SK
American journal of physiology. Renal physiology 2006 Nov;291(5):F1014-20
American journal of physiology. Renal physiology 2006 Nov;291(5):F1014-20
Active role for nibrin in the kinetics of atm activation.
Cerosaletti K, Wright J, Concannon P
Molecular and cellular biology 2006 Mar;26(5):1691-9
Molecular and cellular biology 2006 Mar;26(5):1691-9
The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1.
Kong LJ, Meloni AR, Nevins JR
Molecular cell 2006 Apr 7;22(1):63-71
Molecular cell 2006 Apr 7;22(1):63-71
Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair.
Alt JR, Bouska A, Fernandez MR, Cerny RL, Xiao H, Eischen CM
The Journal of biological chemistry 2005 May 13;280(19):18771-81
The Journal of biological chemistry 2005 May 13;280(19):18771-81
Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.
Cerosaletti K, Concannon P
The Journal of biological chemistry 2004 Sep 10;279(37):38813-9
The Journal of biological chemistry 2004 Sep 10;279(37):38813-9
Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.
Cheng WH, von Kobbe C, Opresko PL, Arthur LM, Komatsu K, Seidman MM, Carney JP, Bohr VA
The Journal of biological chemistry 2004 May 14;279(20):21169-76
The Journal of biological chemistry 2004 May 14;279(20):21169-76
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks.
Sedelnikova OA, Horikawa I, Zimonjic DB, Popescu NC, Bonner WM, Barrett JC
Nature cell biology 2004 Feb;6(2):168-70
Nature cell biology 2004 Feb;6(2):168-70
Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression.
Fan R, Kumaravel TS, Jalali F, Marrano P, Squire JA, Bristow RG
Cancer research 2004 Dec 1;64(23):8526-33
Cancer research 2004 Dec 1;64(23):8526-33
Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation.
Udayakumar D, Bladen CL, Hudson FZ, Dynan WS
The Journal of biological chemistry 2003 Oct 24;278(43):41631-5
The Journal of biological chemistry 2003 Oct 24;278(43):41631-5
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.
Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA, Pilch DR, Rogakou EP, Celeste A, Chen HT, Nussenzweig A, Aladjem MI, Bonner WM, Pommier Y
The Journal of biological chemistry 2003 May 30;278(22):20303-12
The Journal of biological chemistry 2003 May 30;278(22):20303-12
Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients.
Siwicki JK, Degerman S, Chrzanowska KH, Roos G
Experimental cell research 2003 Jul 1;287(1):178-89
Experimental cell research 2003 Jul 1;287(1):178-89
Human MRE11 is inactivated in mismatch repair-deficient cancers.
Giannini G, Ristori E, Cerignoli F, Rinaldi C, Zani M, Viel A, Ottini L, Crescenzi M, Martinotti S, Bignami M, Frati L, Screpanti I, Gulino A
EMBO reports 2002 Mar;3(3):248-54
EMBO reports 2002 Mar;3(3):248-54
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