Ab124364

antibody from Aladdin Scientific Corporation

Targeting: RAD50 hRad50, RAD50-2

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

Ab124364

Provider

Aladdin Scientific Corporation

Product name

Recombinant Rad50 Antibody

Antibody type

Recombinant

Description

Rabbit anti Human Rad50 Antibody, Recombinant (R07-8C0), could be used for WB, IHC and so on.Application:· WB: 1/500-1/1000· IHC: 1/50-1/100Protein FunctionComponent of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

AA 1-425


Antibody clone number

R07-8C0

Vial size

100μl,10μl,1ml,50μl

Concentration

0,6 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.