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LearnMAB413-100
antibody from R&D Systems
Targeting: IL13
ALRH, BHR1, IL-13, MGC116786, MGC116788, MGC116789, P600
Western blot
Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
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- Product number
- MAB413-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse IL-13 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects mouse IL-13 in ELISAs and Western blots. In ELISAs, less than 0.1% cross-reactivity with recombinant human IL-13 is observed.
- Reactivity
- Mouse
- Host
- Rat
- Conjugate
- Unconjugated
- Antigen sequence
P20109- Isotype
- IgG
- Antibody clone number
- 38213
- Vial size
- 100 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages.
Macrophage migration inhibitory factor deficiency enhances immune response to Nippostrongylus brasiliensis.
RSV vaccine-enhanced disease is orchestrated by the combined actions of distinct CD4 T cell subsets.
CD8⁺ cells regulate the T helper-17 response in an experimental murine model of Sjögren syndrome.
Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development.
Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease.
IL-6 is required for airway mucus production induced by inhaled fungal allergens.
FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions.
Loss of pro-apoptotic Bim promotes accumulation of pulmonary T lymphocytes and enhances allergen-induced goblet cell metaplasia.
Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile.
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines.
Persistence of bronchopulmonary hyper-reactivity and eosinophilic lung inflammation after anti-IL-5 or -IL-13 treatment in allergic BALB/c and IL-4Ralpha knockout mice.
Zhao J, Okamoto Y, Asano Y, Ishimaru K, Aki S, Yoshioka K, Takuwa N, Wada T, Inagaki Y, Takahashi C, Nishiuchi T, Takuwa Y
PloS one 2018;13(5):e0197604
PloS one 2018;13(5):e0197604
Macrophage migration inhibitory factor deficiency enhances immune response to Nippostrongylus brasiliensis.
Damle SR, Martin RK, Cross JV, Conrad DH
Mucosal immunology 2017 Jan;10(1):205-214
Mucosal immunology 2017 Jan;10(1):205-214
RSV vaccine-enhanced disease is orchestrated by the combined actions of distinct CD4 T cell subsets.
Knudson CJ, Hartwig SM, Meyerholz DK, Varga SM
PLoS pathogens 2015 Mar;11(3):e1004757
PLoS pathogens 2015 Mar;11(3):e1004757
CD8⁺ cells regulate the T helper-17 response in an experimental murine model of Sjögren syndrome.
Zhang X, Schaumburg CS, Coursey TG, Siemasko KF, Volpe EA, Gandhi NB, Li DQ, Niederkorn JY, Stern ME, Pflugfelder SC, de Paiva CS
Mucosal immunology 2014 Mar;7(2):417-27
Mucosal immunology 2014 Mar;7(2):417-27
Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development.
Mosconi E, Rekima A, Seitz-Polski B, Kanda A, Fleury S, Tissandie E, Monteiro R, Dombrowicz DD, Julia V, Glaichenhaus N, Verhasselt V
Mucosal immunology 2010 Sep;3(5):461-74
Mucosal immunology 2010 Sep;3(5):461-74
Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease.
Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM
Journal of immunology (Baltimore, Md. : 1950) 2010 Apr 15;184(8):4159-69
Journal of immunology (Baltimore, Md. : 1950) 2010 Apr 15;184(8):4159-69
IL-6 is required for airway mucus production induced by inhaled fungal allergens.
Neveu WA, Allard JB, Dienz O, Wargo MJ, Ciliberto G, Whittaker LA, Rincon M
Journal of immunology (Baltimore, Md. : 1950) 2009 Aug 1;183(3):1732-8
Journal of immunology (Baltimore, Md. : 1950) 2009 Aug 1;183(3):1732-8
FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions.
Daniel C, Sartory NA, Zahn N, Schmidt R, Geisslinger G, Radeke HH, Stein JM
Molecular immunology 2007 Jul;44(13):3305-16
Molecular immunology 2007 Jul;44(13):3305-16
Loss of pro-apoptotic Bim promotes accumulation of pulmonary T lymphocytes and enhances allergen-induced goblet cell metaplasia.
Pierce J, Rir-Sima-Ah J, Estrada I, Wilder J, Strasser A, Tesfaigzi Y
American journal of physiology. Lung cellular and molecular physiology 2006 Nov;291(5):L862-70
American journal of physiology. Lung cellular and molecular physiology 2006 Nov;291(5):L862-70
Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile.
Wen H, Hogaboam CM, Gauldie J, Kunkel SL
The American journal of pathology 2006 Jun;168(6):1940-50
The American journal of pathology 2006 Jun;168(6):1940-50
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines.
Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, Gorman DM, Bazan JF, Kastelein RA
Immunity 2005 Nov;23(5):479-90
Immunity 2005 Nov;23(5):479-90
Persistence of bronchopulmonary hyper-reactivity and eosinophilic lung inflammation after anti-IL-5 or -IL-13 treatment in allergic BALB/c and IL-4Ralpha knockout mice.
Proust B, Nahori MA, Ruffie C, Lefort J, Vargaftig BB
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003 Jan;33(1):119-31
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003 Jan;33(1):119-31
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Cell Proliferation Induced by IL-13 and Neutralization by Mouse IL-13 Antibody. Recombinant Mouse IL-13 (Catalog # 413-ML) stimulates proliferation in the TF-1 human erythroleukemic cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse IL-13 (10 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse IL-13 Monoclonal Antibody (Catalog # MAB413). The ND50 is typically 0.3-0.8 µg/mL.
