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- Antibody Data
- Antigen structure
- References [20]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 15087-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15087-1-AP, RRID:AB_2186411
- Product name
- SEC61B antibody
- Antibody type
- Polyclonal
- Description
- SEC61B antibody (Cat. #15087-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NEMF-mediated Listerin-independent mitochondrial translational surveillance by E3 ligase Pirh2 and mitochondrial protease ClpXP.
A regulatory circuit comprising the CBP and SIRT7 regulates FAM134B-mediated ER-phagy.
Vps9d1 regulates tubular endosome formation through specific activation of Rab22A.
Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques.
Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease.
cDNA expression library screening revealed novel functional genes involved in clear cell carcinogenesis of the ovary in vitro.
Transmembrane Prolyl 4-Hydroxylase is a Novel Regulator of Calcium Signaling in Astrocytes.
QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.
Propofol induces the elevation of intracellular calcium via morphological changes in intracellular organelles, including the endoplasmic reticulum and mitochondria.
Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.
CReP mediates selective translation initiation at the endoplasmic reticulum.
Efficient Gene Silencing by Adenine Base Editor-Mediated Start Codon Mutation.
Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum.
A critical role of VMP1 in lipoprotein secretion.
Intrinsically Disordered Protein TEX264 Mediates ER-phagy.
Changes in Corticotrope Gene Expression Upon Increased Expression of Peptidylglycine α-Amidating Monooxygenase.
The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival.
Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17.
Asna1/TRC40 Controls β-Cell Function and Endoplasmic Reticulum Homeostasis by Ensuring Retrograde Transport.
Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway.
Lv L, Mo J, Qing Y, Wang S, Chen L, Mei A, Xu R, Huang H, Tan J, Li Y, Liu J
Cell reports 2024 Mar 26;43(3):113860
Cell reports 2024 Mar 26;43(3):113860
A regulatory circuit comprising the CBP and SIRT7 regulates FAM134B-mediated ER-phagy.
Wang X, Jiang X, Li B, Zheng J, Guo J, Gao L, Du M, Weng X, Li L, Chen S, Zhang J, Fang L, Liu T, Wang L, Liu W, Neculai D, Sun Q
The Journal of cell biology 2023 May 1;222(5)
The Journal of cell biology 2023 May 1;222(5)
Vps9d1 regulates tubular endosome formation through specific activation of Rab22A.
Nakashima S, Matsui T, Fukuda M
Journal of cell science 2023 Mar 15;136(6)
Journal of cell science 2023 Mar 15;136(6)
Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques.
Lee JH, Yang DS, Goulbourne CN, Im E, Stavrides P, Pensalfini A, Chan H, Bouchet-Marquis C, Bleiwas C, Berg MJ, Huo C, Peddy J, Pawlik M, Levy E, Rao M, Staufenbiel M, Nixon RA
Nature neuroscience 2022 Jun;25(6):688-701
Nature neuroscience 2022 Jun;25(6):688-701
Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease.
Rimal S, Li Y, Vartak R, Geng J, Tantray I, Li S, Huh S, Vogel H, Glabe C, Grinberg LT, Spina S, Seeley WW, Guo S, Lu B
Acta neuropathologica communications 2021 Oct 18;9(1):169
Acta neuropathologica communications 2021 Oct 18;9(1):169
cDNA expression library screening revealed novel functional genes involved in clear cell carcinogenesis of the ovary in vitro.
Yamada Y, Miyamoto T, Higuchi S, Ono M, Kobara H, Asaka R, Ando H, Suzuki A, Shiozawa T
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 2021 Jan;41(1):100-105
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 2021 Jan;41(1):100-105
Transmembrane Prolyl 4-Hydroxylase is a Novel Regulator of Calcium Signaling in Astrocytes.
Byts N, Sharma S, Laurila J, Paudel P, Miinalainen I, Ronkainen VP, Hinttala R, Törnquist K, Koivunen P, Myllyharju J
eNeuro 2021 Jan-Feb;8(1)
eNeuro 2021 Jan-Feb;8(1)
QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.
You K, Wang L, Chou CH, Liu K, Nakata T, Jaiswal A, Yao J, Lefkovith A, Omar A, Perrigoue JG, Towne JE, Regev A, Graham DB, Xavier RJ
Science (New York, N.Y.) 2021 Jan 1;371(6524)
Science (New York, N.Y.) 2021 Jan 1;371(6524)
Propofol induces the elevation of intracellular calcium via morphological changes in intracellular organelles, including the endoplasmic reticulum and mitochondria.
Urabe T, Yanase Y, Motoike S, Harada K, Hide I, Tanaka S, Tsutsumi YM, Kawamoto M, Sakai N
European journal of pharmacology 2020 Oct 5;884:173303
European journal of pharmacology 2020 Oct 5;884:173303
Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.
Pensalfini A, Kim S, Subbanna S, Bleiwas C, Goulbourne CN, Stavrides PH, Jiang Y, Lee JH, Darji S, Pawlik M, Huo C, Peddy J, Berg MJ, Smiley JF, Basavarajappa BS, Nixon RA
Cell reports 2020 Nov 24;33(8):108420
Cell reports 2020 Nov 24;33(8):108420
CReP mediates selective translation initiation at the endoplasmic reticulum.
Kastan JP, Dobrikova EY, Bryant JD, Gromeier M
Science advances 2020 Jun;6(23):eaba0745
Science advances 2020 Jun;6(23):eaba0745
Efficient Gene Silencing by Adenine Base Editor-Mediated Start Codon Mutation.
Wang X, Liu Z, Li G, Dang L, Huang S, He L, Ma Y, Li C, Liu M, Yang G, Huang X, Zhou F, Ma X
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Feb 5;28(2):431-440
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Feb 5;28(2):431-440
Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum.
Longman D, Jackson-Jones KA, Maslon MM, Murphy LC, Young RS, Stoddart JJ, Hug N, Taylor MS, Papadopoulos DK, Cáceres JF
Genes & development 2020 Aug 1;34(15-16):1075-1088
Genes & development 2020 Aug 1;34(15-16):1075-1088
A critical role of VMP1 in lipoprotein secretion.
Morishita H, Zhao YG, Tamura N, Nishimura T, Kanda Y, Sakamaki Y, Okazaki M, Li D, Mizushima N
eLife 2019 Sep 17;8
eLife 2019 Sep 17;8
Intrinsically Disordered Protein TEX264 Mediates ER-phagy.
Chino H, Hatta T, Natsume T, Mizushima N
Molecular cell 2019 Jun 6;74(5):909-921.e6
Molecular cell 2019 Jun 6;74(5):909-921.e6
Changes in Corticotrope Gene Expression Upon Increased Expression of Peptidylglycine α-Amidating Monooxygenase.
Mains RE, Blaby-Haas C, Rheaume BA, Eipper BA
Endocrinology 2018 Jul 1;159(7):2621-2639
Endocrinology 2018 Jul 1;159(7):2621-2639
The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival.
Norlin S, Parekh V, Edlund H
Development (Cambridge, England) 2018 Jan 3;145(1)
Development (Cambridge, England) 2018 Jan 3;145(1)
Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17.
Matsui T, Jiang P, Nakano S, Sakamaki Y, Yamamoto H, Mizushima N
The Journal of cell biology 2018 Aug 6;217(8):2633-2645
The Journal of cell biology 2018 Aug 6;217(8):2633-2645
Asna1/TRC40 Controls β-Cell Function and Endoplasmic Reticulum Homeostasis by Ensuring Retrograde Transport.
Norlin S, Parekh VS, Naredi P, Edlund H
Diabetes 2016 Jan;65(1):110-9
Diabetes 2016 Jan;65(1):110-9
Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway.
Ninagawa S, Okada T, Sumitomo Y, Horimoto S, Sugimoto T, Ishikawa T, Takeda S, Yamamoto T, Suzuki T, Kamiya Y, Kato K, Mori K
The Journal of cell biology 2015 Nov 23;211(4):775-84
The Journal of cell biology 2015 Nov 23;211(4):775-84
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 15087-1-AP(SEC61B antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SEC61B antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SEC61B. This antibody recognizes human, mouse antigen. The SEC61B antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 15087-1-AP(SEC61B antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 15087-1-AP(SEC61B antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
