11-8065-25

antibody from ABEOMICS Inc.
Targeting: MAFA hMafA, RIPE3b1
Provider product page for 11-8065-25

Antibody data

Product number
11-8065-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-Mafa Antibody
Antibody type
Polyclonal
Description
Musculoaponeurotic fibrosarcoma oncogene family A (MafA) is a pancreatic transcriptional factor that is important to pancreatic beta-cell function. It is a member of the musculo-aponeurotic fibrosarcoma oncogene family, a subgroup of the basic leucine zipper transcription factors with homology to the v-Maf oncoprotein. It acts as a transcriptional regulator that promotes the expression of genes important in glucose-induced insulin secretion, such as insulin, glucokinase and glucose transporter protein-2. Mafa is unique in being exclusively expressed at the secondary and principal phase of insulin-expressing cell production during pancreas organogenesis and is the only transcriptional activator present exclusively in islet beta-cells thus may be involved in pathogenesis of diabetes.
Reactivity
Human
Host
Rabbit
Antigen sequence
A partial length recombinant Mafa p
rotein (amino acids 192-353) was us
ed as the immunogen for this antibo
dy.
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
MAFA protein structure - 11-8065-25 shown in red.